Mayo Clinic Hyperoxaluria Center

The Mayo Clinic Hyperoxaluria Center is a clinical care and research center staffed by physician scientists devoted to the study of primary hyperoxaluria. The goals of the center are to provide a resource for the diagnosis and care of patients with primary hyperoxaluria, to discover factors that predict or determine loss of kidney function in patients with primary hyperoxaluria, and to develop effective treatments.

The center is a part of the Rare Kidney Stone Consortium, whose goal is to improve care and outcomes for patients with rare stone diseases.

Care of Patients

Mayo Clinic in Rochester is one of the most experienced centers in the world for treating patients with hyperoxaluric stone disease. (See information on treatment of hyperoxaluria.) Mayo Clinic's Hyperoxaluria Center has established programs for the care of both children and adults with this condition. All diagnostic and treatment services for patients are coordinated through the Hyperoxaluria Center, including kidney and liver transplantation and all types of dialysis — all in partnership with the patient's home physician.

In addition, the Hyperoxaluria Center offers patients the opportunity to participate in clinical trials testing new treatment approaches.


The center provides a resource for clinical care of patients with primary hyperoxaluria and facilitates multidisciplinary research to better understand this disorder. Collaboration among investigators in Radiology, Laboratory Medicine and the basic sciences has been established. The center compiles statistics on patient outcomes and houses an international data registry, under the sponsorship of the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK).

Ongoing research activities by members of the center include:

  • Determination of specific genetic mutations in primary hyperoxaluria patients, and correlation with disease outcomes
  • Development of newer radiology techniques in order to measure renal calcium content and stones
  • Development of better rat models of hyperoxaluria
  • Study of the mechanism(s) by which oxalate changes cell function
  • The center also houses a bank for urine, plasma, whole blood and liver samples collected from patients to facilitate investigation and collaborative research.

Contact Us

Phone: 800-270-4637 (toll-free)

The Mayo Clinic Hyperoxaluria Center is supported by the Rare Diseases Clinical Research Network of the National Institutes of Health and by the The Oxalosis and Hyperoxaluria Foundation (OHF).