Hyperoxaluria Center Overview

The doctors and scientists at the Hyperoxaluria Center on Mayo Clinic's campus in Minnesota are widely respected leaders in caring for people with primary hyperoxaluria and in studying how to improve its diagnosis and treatment.

This rare inherited kidney disease causes kidney stones. Symptoms most often occur during childhood or adolescence. Treatment may involve taking medications, adjusting your fluid intake and diet, or undergoing surgery to remove kidney stones. Eventually, if you lose kidney function you may need dialysis or a kidney transplant.

Coordinated care

Your kidney doctor (nephrologist) or a doctor who specializes in caring for children with kidney conditions (pediatric nephrologist) works closely with you, your primary care doctor, a dietitian, nurses, and specialists in radiology and pathology. This multidisciplinary, coordinated approach to diagnostic services ensures that your visits are efficient and complete. The center also serves as a resource to your primary care doctor and local care team as they provide treatment services.

A partnership between research and clinical care

Because the Hyperoxaluria Center combines clinical care and research, its physician-scientists have a valuable opportunity to conduct research at a level that very few medical centers can attain. This close collaboration between clinical care and research produces opportunities for discovery and results. For example, the center:

  • Is a part of the Rare Kidney Stone Consortium, which shares Mayo Clinic's goal of improving the care and outcomes for people with rare stone diseases
  • Compiles statistics on patient outcomes and houses an international data registry, under the sponsorship of the National Institute of Diabetes and Digestive and Kidney Diseases
  • Houses a biobank for urine, plasma, whole blood and liver samples collected from people with primary hyperoxaluria

Research studies include:

  • Finding gene mutations in people with primary hyperoxaluria and discovering how those genes may be related to disease outcomes
  • Developing radiology techniques to measure renal calcium content and stones
  • Studying the disease at the cellular level
  • Studying new treatments for primary and enteric hyperoxaluria

Talk with your doctor about opportunities to participate in clinical trials testing new treatment approaches for primary hyperoxaluria.

Contact Us

  1. Email: hyperoxaluriacenter@mayo.edu
  2. Phone: 800-270-4637 (toll-free)

The Mayo Clinic Hyperoxaluria Center is supported by the Rare Diseases Clinical Research Network of the National Institutes of Health and by the Oxalosis & Hyperoxaluria Foundation.

Oct. 14, 2023