The Ehlers-Danlos Syndrome Clinic at Mayo Clinic's campus in Jacksonville, Florida, provides expert evaluation and treatment for all forms of EDS, including:
- Rare types of EDS with known genetic causes.
- Hypermobile EDS (hEDS).
- Hypermobility spectrum disorders (HSD).
Living with Ehlers-Danlos syndrome (EDS) can be challenging. Symptoms can be different for each person. You may have ongoing joint pain, fragile skin, digestive issues, fatigue, dizziness or other symptoms that are hard to explain. Many people spend years trying to get a clear diagnosis and effective care.
Getting an evaluation from specialists who understand EDS and its full range of symptoms is important. An accurate diagnosis helps guide the right treatment.
At the EDS Clinic, experts in connective tissue disorders work closely with clinical genomics specialists to confirm your diagnosis and identify your EDS type. This helps your team create a care plan based on your needs.
Treatment focuses on helping you manage symptoms, improve daily function and lower the risk of complications, such as joint dislocations and early-onset arthritis.
Mayo Clinic Connect: Ehlers-Danlos Syndrome Blog
What is Ehlers-Danlos syndrome?
Ehlers-Danlos syndrome (EDS) is a group of inherited conditions that affect the connective tissues — primarily the skin, joints and blood vessels. Symptoms and severity can vary from person to person and depends on the type of EDS you have.
Many people with EDS have:
- Overly flexible joints that sprain or dislocate easily.
- Skin that stretches more than usual and is fragile or slow to heal.
Ongoing joint pain, fatigue, and digestive and nervous system symptoms are also common. These complex symptoms can affect daily activities and quality of life.
A team approach to EDS care
Specialists in connective tissue disorders in the Division of General Internal Medicine lead your care. Your team may include physician assistants, medical geneticists, genetic counselors and nurses with experience in Ehler-Danlos syndrome.
Because EDS can affect many parts of the body, your care team also may work with other Mayo Clinic specialists in:
Your care team works together to confirm your diagnosis and create a care plan based on your needs. This team approach helps make sure your care is clear, connected and focused on your whole health.
What to expect
At your first visit to the Ehlers-Danlos Syndrome (EDS) Clinic in Florida, you receive a complete diagnostic evaluation for EDS. This includes a review of your medical history and a physical exam. Your healthcare professional may:
- Examine your skin and joints.
- Listen to your heart and lungs.
- Check your blood pressure, heart rate and breathing.
If you have not had genetic testing, your team may recommend it based on your evaluation.
At your second visit, your healthcare professional reviews your care plan, answers your questions and explains next steps.
After your second visit, your care usually returns to your local healthcare professional. The EDS Clinic works closely with your local primary care professional and specialists to coordinate your ongoing care. Some people may return to Mayo Clinic if their condition changes or they need additional specialty care.
Research and clinical trials
Mayo Clinic physician-scientists and other researchers study ways to improve care for Ehlers-Danlos syndrome (EDS). Current research focuses on:
- Identifying the causes of hypermobile EDS (hEDS) and hypermobility spectrum disorder (HSD).
- Discovering how hEDS and HSD may be linked to other long-term health conditions.
- Finding better ways to diagnose and treat hEDS and HSD.
You may have the opportunity to take part in an EDS-related clinical trial or research study at Mayo Clinic. Talk with your healthcare professional about whether a clinical trial may be right for you.
Contact
Feb. 03, 2026