General Internal Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Sex and Age Differences in Ehlers Danlos Syndrome Patients

   Jacksonville, Fla.

   The purpose of this study is to determine whether serum biomarkers and comorbidities differ between subjects with hEDS/HSD vs. other non-hypermobile EDS subtypes and whether sex and/or age differences exist, and to determine whether serum biomarkers and comorbidities differ between subjects with hEDS vs. HSD and whether sex and/or age differences exist.

2. Sponge and Eosinophil Peroxidase (EPO) Staining

   Rochester, Minn.

   Are we able to use the EPO staining technique using the sponge ?

3. Fecal Microbiome Transplant National Registry

   Rochester, Minn.

   The overarching goal of the FMT registry is to expand knowledge and optimize practice in the transplantation of fecal microbiota or other gut-related-microbiota products.

4. A Study of Eosinophil Activities in Healthy Subjects and Subjects with Allergic/immunologic Disorders

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to investigate eosinophil activities and interactions with other cell types in vitro to better understand how they contribute to health and disease.  Specifically, we will isolate eosinophils and other white blood cells from peripheral blood and subject them to various stimuli as well as co-culture conditions to examine activities and interactions. 

5. Whole Exome Sequencing and Other Emerging Technologies of Endoscopic Ultrasound Cytopathology

   Rochester, Minn.

   The purpose of this research study is to gather information on the feasibility of performing novel molecular analysis on Endoscopic Ultrasound acquired cytologic material and to assess molecular changes in cytology samples to see if that may aid treatment decision planning for future patients.

6. A Study to Evaluate the Progression of Gastrointestinal and Fatigue Symptoms in the Scleroderma Population Seen at Mayo Clinic Arizona

   Scottsdale/Phoenix, Ariz.

   The purpose of this study is to evaluate the progression of gastrointestinal and fatigue symptoms over time (approximately 5 years) in the scleroderma population seen at Mayo Clinic Arizona.

7. Collection of Tissue and Blood in Patients with Allergic and Immunologic Disorders

   Scottsdale/Phoenix, Ariz.

   Allergic and immunologic disorders are very common but some are very poorly understood. Numerous studies of the epidemiology, characteristics, diagnosis and treatment of these disorders are urgently needed to identify and optimally treat affected patients. Though numerous challenges impact the progress of research in this area, specimens are needed to test new hypotheses and methodologies.  We aim to create a registry and biorepository of tissue and fluid specimens for future studies.

8. A Study for Sources of Pulmonary Congestion Associated with Heart Failure

   Rochester, Minn.

   The purpose of this study is to measure and identify chest fluid volumes associated with heart failure and to determine their impact on lung structure and function, and also assess the effect of body position on shifts in fluid and the effects of this on lung function, mechanics and gas exchange.

9. A Study to Enroll Patients of Rheumatic Diseases and First-degree Relatives in a Biobank

   Rochester, Minn.

   The purpose of this study is to enroll rheumatic disease patients and first-degree relatives in a biobank, and to follow them over time to assess health outcomes and collect additional specimens.

10. A Study of Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure that has Preserved Ejection Fraction

    Rochester, Minn., La Crosse, Wis., Red Wing, Minn., Mankato, Minn., Cannon Falls, Minn., Albert Lea, Minn., Austin, Minn.

    Participants with heart failure with preserved ejection fraction will undergo 12 weeks of cardiac rehabilitation for exercise training (ET) and be randomized to either nebulized sodium nitrite inhalation solution or placebo inhalation solution (normal saline) through the training period. Study drug is administered 3 times daily during daytime hours with one of these doses being immediately prior to onset of ET sessions throughout the 12 week trial. The objective is to determine if the inhaled sodium nitrite improves the clinical responses and tolerability of ET.