Anesthesiology and Perioperative Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Learning More about How your Brain Works with Decreased Levels of Oxygen

   Rochester, Minn.

   The specific aim of this proposal is (1) to develop a human model of hypoxia in which cerebrovascular reactivity and cognitive function can be simultaneously measured and (2) develop pilot data in our laboratory on the relationship between cerebrovascular reactivity and cognitive function during three different hypoxic conditions with and without addition of inspired CO2 as a mechanism to maintain cerebral blood flow.

2. A Study to Evaluate Prevalence of Hypogonadism in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioid-induced hypogonadism (OIH) in chronic pain patients before and after completing 3 weeks Interdisciplinary Pain Rehabilitation Program (IPRP) at Pain Rehabilitation Center (PRC) at Mayo Clinic/Florida.

3. A Study to Evaluate Unintended Prolonged Opioid Use

   Rochester, Minn.

   The primary purpose of this study is to identify patient characteristics that are associated with unintended prolonged opioid use (UPUO).

4. A Study to Analyze the Amount of Antibiotic Absorbed into Tissues Comparing Two Different Modes of Administration

   Scottsdale/Phoenix, Ariz.

   This study aims to investigate whether administration of vancomycin intravenously via a Bier block, typically a method for providing regional anesthesia in the upper extremity, leads to higher soft tissue and bone antibiotic concentrations compared to routine intravenous administration.  Higher tissue concentrations could be desirable for prophylaxis in complex upper extremity reconstruction, or for treatment of difficult infections.

5. Study to Evaluate the Effects of Vitamin B3 Derivative on Bone, Skeletal, Muscle and Metabolic Functions in Aging

   Rochester, Minn.

   The purpose of this study is to evaluate the effects of vitamin B3 derivative on bone, skeletal, muscle and metabolic functions in aging.

6. A Study to Evaluate Ultrasound-guided Erector Spinae Plane Blocks

   Rochester, Minn.

   The purpose of this study is to to demonstrate the feasibility of performing ultrasound-guided erector spinae plane blocks in the Emergency Department (ED) and Intensive Care Unit (ICU).

7. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

8. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

9. Chronic Pain Biobank

   Jacksonville, Fla.

   The purpose of this study is to create a biorepository for samples of chronic pain patients.

10. A Study to Analyze the Effects of Exparel for Post-Surgery Pain Control in Patients Undergoing Penile Prosthesis Placement

    Rochester, Minn.

    The purpose of this study is to determine the effects of liposomal bupivacaine vs lidocaine/bupivacaine mixture in patients’ undergoing surgical placement of a penile prosthesis.