Anesthesiology and Perioperative Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. A Study to Evaluate Prevalence of Hypogonadism in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioid-induced hypogonadism (OIH) in chronic pain patients before and after completing 3 weeks Interdisciplinary Pain Rehabilitation Program (IPRP) at Pain Rehabilitation Center (PRC) at Mayo Clinic/Florida.

2. A Study About Comparing a New Test of Blood Clotting with Standard Tests of Blood Clotting in Patients Who are Undergoing Heart Surgery

   Rochester, Minn.

   The purpose of this study is to determine the correlation of the MCTS - CT with standard coagulation tests and coagulation factor levels.

3. Study to Evaluate the Effects of Vitamin B3 Derivative on Bone, Skeletal, Muscle and Metabolic Functions in Aging

   Rochester, Minn.

   The purpose of this study is to evaluate the effects of vitamin B3 derivative on bone, skeletal, muscle and metabolic functions in aging.

4. A Study to Evaluate Ultrasound-guided Erector Spinae Plane Blocks

   Rochester, Minn.

   The purpose of this study is to to demonstrate the feasibility of performing ultrasound-guided erector spinae plane blocks in the Emergency Department (ED) and Intensive Care Unit (ICU).

5. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

6. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

7. A Study to Analyze the Effects of Exparel for Post-Surgery Pain Control in Patients Undergoing Penile Prosthesis Placement

   Rochester, Minn.

   The purpose of this study is to determine the effects of liposomal bupivacaine vs lidocaine/bupivacaine mixture in patients’ undergoing surgical placement of a penile prosthesis.

8. Tobacco Dependence Intervention Knowledge, Practices, and Attitudes among Registered Nurses

   Rochester, Minn.

   The specific aim of this study is to determine if the implementation of a tobacco dependence intervention, among registered nurses on Gonda 7 caring for ambulatory surgical patients, results in a change in the knowledge, practices, and attitudes of patient tobacco use assessment as compared to baseline. 

9. A Study to Evaluate AAV8-human Cocaine Hydrolase to Treat Cocaine Use Disorder

   Rochester, Minn.

   The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use.  This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector.  We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission.  

10. A Study to Evaluate Time to First Movement for Fetal Surgery Patients Injected with Intramuscular Anesthesia

    Rochester, Minn.

    The purpose of this study is to determine the time from intramuscular injection to the time of first fetal movement after a fetal surgery procedure.