طب التخدير والفترة المحيطة بالجراحة

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. A Study to Evaluate Prevalence of Hypogonadism in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioid-induced hypogonadism (OIH) in chronic pain patients before and after completing 3 weeks Interdisciplinary Pain Rehabilitation Program (IPRP) at Pain Rehabilitation Center (PRC) at Mayo Clinic/Florida.

2. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

3. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

4. Tobacco Dependence Intervention Knowledge, Practices, and Attitudes among Registered Nurses

   Rochester, Minn.

   The specific aim of this study is to determine if the implementation of a tobacco dependence intervention, among registered nurses on Gonda 7 caring for ambulatory surgical patients, results in a change in the knowledge, practices, and attitudes of patient tobacco use assessment as compared to baseline. 

5. A Study to Evaluate Time to First Movement for Fetal Surgery Patients Injected with Intramuscular Anesthesia

   Rochester, Minn.

   The purpose of this study is to determine the time from intramuscular injection to the time of first fetal movement after a fetal surgery procedure.

6. A Study to Evaluate AAV8-human Cocaine Hydrolase to Treat Cocaine Use Disorder

   Rochester, Minn.

   The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use.  This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector.  We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission.  

7. Text Messaging Smoking Cessation Program in Surgical Patients

   Rochester, Minn.

   The goal of this study is to evaluate using a text messaging smoking cessation service in surgical patients during the perioperative period (before scheduled surgery and for 4 weeks post-operatively).

8. A Study to Assess Opioid-Induced Respiratory Depression Using Diaphragm Muscle Shear Wave Elastography

   Rochester, Minn.

   The purpose of this study is to determine the impact of opioid administration on diaphragm muscle forces during resting breathing and during higher force maneuvers by using a non-invasive shear wave elastography (SWE) method.

9. Response of Continuous Recombinant Antithrombin Infusion in Postcardiotomy ECMO Patients

   Rochester, Minn.

   The objective of this study will be to prospectively evaluate the response of a continuous infusion of recombinant human antithrombin concentrate (rhAT) (ATRYN®) to achieve and maintain the AT activity within a specified range in adult patients that require extracorporeal membrane oxygenation (ECMO) following cardiopulmonary bypass (CPB) and cardiac surgery.

10. A Study of Serum Baclofen Levels in Patients with Intrathecal Baclofen Therapy

    Rochester, Minn.

    The purpose of this study is to determine serum levels of baclofen in patients with spasticity managed with long-term intrathecal baclofen therapy. 

بالأسفل التجارب السريرية الحالية.

غربل قائمة الدراسات هذه بالموقع والحالة وغيرها.

1. A Study to Evaluate Prevalence of Hypogonadism in Patients with Chronic Pain

   Jacksonville, Fla.

   The purpose of this study is to evaluate the hormonal profile related to opioid-induced hypogonadism (OIH) in chronic pain patients before and after completing 3 weeks Interdisciplinary Pain Rehabilitation Program (IPRP) at Pain Rehabilitation Center (PRC) at Mayo Clinic/Florida.

2. Exparel Injection for Postoperative Orbital Pain

   Rochester, Minn.

   After surgery to remove the eye, either by enucleation or evisceration, patients have variable levels of pain for several postoperative days. Some patients have almost no discomfort while others require significant amounts of oral narcotics and report pain of 10 out of 10 on a numerical rating scale. The current operative standard is to infiltrate the eye socket with 0.5% bupivacaine during surgery leading to several hours of postoperative analgesia. In 2011, Pacira Pharmaceuticals released a bupivacaine liposomal injectable suspension (Exparel, 1.3%) which offers sustained release of bupivacaine giving postoperative pain control for up to 72 hours. This medication has been used in numerous surgeries including inguinal hernia repair, hemorrhoidectomy, bunionectomy, breast reconstruction, and orthopedic surgery, and the literature reports improved pain control, decreased use of oral opioids, and increased patient satisfaction. There are no reports of the use of Exparel in the ophthalmic literature. The investigators propose a randomized, controlled trial to compare the postoperative pain control offered by sustained release bupivacaine to that offered by standard plain bupivacaine after enucleation or evisceration.

3. A Study to Analyze the Effects of Buprenorphine on Hyperalgesia in Patients with Opioid Use Disorder

   Rochester, Minn.

   The purpose of this study is to investigate the effects of buprenorphine on hyperalgesia (HP) perception in adults undergoing treatment for opioid use disorder (OUD).

4. Tobacco Dependence Intervention Knowledge, Practices, and Attitudes among Registered Nurses

   Rochester, Minn.

   The specific aim of this study is to determine if the implementation of a tobacco dependence intervention, among registered nurses on Gonda 7 caring for ambulatory surgical patients, results in a change in the knowledge, practices, and attitudes of patient tobacco use assessment as compared to baseline. 

5. A Study to Evaluate Time to First Movement for Fetal Surgery Patients Injected with Intramuscular Anesthesia

   Rochester, Minn.

   The purpose of this study is to determine the time from intramuscular injection to the time of first fetal movement after a fetal surgery procedure.

6. A Study to Evaluate AAV8-human Cocaine Hydrolase to Treat Cocaine Use Disorder

   Rochester, Minn.

   The purpose of this study is to see if an experimental agent, when given to subjects who wish to abstain from cocaine, will decrease their craving for cocaine and prevent them from relapsing and returning to cocaine use.  This experimental agent is called AAV8-hCocH; and it is a gene modified viral vector.  We want to determine the safety of its use in adults who have a cocaine use disorder in sustained remission.  

7. Text Messaging Smoking Cessation Program in Surgical Patients

   Rochester, Minn.

   The goal of this study is to evaluate using a text messaging smoking cessation service in surgical patients during the perioperative period (before scheduled surgery and for 4 weeks post-operatively).

8. A Study to Assess Opioid-Induced Respiratory Depression Using Diaphragm Muscle Shear Wave Elastography

   Rochester, Minn.

   The purpose of this study is to determine the impact of opioid administration on diaphragm muscle forces during resting breathing and during higher force maneuvers by using a non-invasive shear wave elastography (SWE) method.

9. Response of Continuous Recombinant Antithrombin Infusion in Postcardiotomy ECMO Patients

   Rochester, Minn.

   The objective of this study will be to prospectively evaluate the response of a continuous infusion of recombinant human antithrombin concentrate (rhAT) (ATRYN®) to achieve and maintain the AT activity within a specified range in adult patients that require extracorporeal membrane oxygenation (ECMO) following cardiopulmonary bypass (CPB) and cardiac surgery.

10. A Study of Serum Baclofen Levels in Patients with Intrathecal Baclofen Therapy

    Rochester, Minn.

    The purpose of this study is to determine serum levels of baclofen in patients with spasticity managed with long-term intrathecal baclofen therapy.