Erik K. St Louis, M.D.

  1. Neurologist
  2. Pulmonologist
  3. Neurophysiologist



  1. Rochester, Minnesota



Erik K. St. Louis, M.D, M.S., is Associate Professor of Neurology, Co-Director of the Center for Sleep Medicine and Sleep Medicine Fellowship Program Director, and Consultant in Sleep Medicine and Neurology at Mayo Clinic, Rochester, Minnesota. Other current Mayo Clinic leadership positions include Enterprise Director for Sleep Neurology, Associate Dean for Maintenance of Certification in the Mayo School for Continuous Professional Development, and Physician Director for Education Information Management. Nationally, he serves on the Editorial Boards of the American Academy of Neurology Continuum and Frontiers in Sleep and Chronobiology, and as Co-Chair of the American Epilepsy Society Sleep and Epilepsy Interest Group.

Dr. St. Louis is board certified in Adult Neurology, Sleep Medicine, Epilepsy, EEG/Epilepsy Monitoring, Clinical Neurophysiology, and Vascular Neurology by the American Boards of Psychiatry and Neurology, Clinical Neurophysiology, and Sleep Medicine. He was educated at St. Olaf College, the Medical College of Wisconsin, Mayo Clinic, and the University of Iowa. He previously co-directed the Marshfield Clinic and University of Iowa comprehensive epilepsy programs for ten years. Research interests include clinical and neurophysiologic aspects of REM sleep behavior disorder (RBD) currently under support of the Mayo Center for Clinical and Translational Science (CCaTS) and Michael J. Fox Foundation, and the complex interrelationships between sleep and epilepsy.

The Mayo Sleep and Cognitive Neurophysiology Laboratory, directed by Dr. St. Louis, has pioneered new quantitative polysomnographic analysis methods and established diagnostic standards for RBD, and is currently analyzing these measures as a biomarker for synucleinopathy neurodegeneration. Other current research projects include analyzing sleep and waking physiologic risk profiles for sudden unexpected death in epilepsy (SUDEP), co-morbid sleep apnea in epilepsy, and using EEG and ERP signal analyses to characterize cognitive and cerebral functioning following sleep deprivation. Dr. St. Louis developed and co-edited the book "Epilepsy and the Interictal State: Co-morbidities and Quality of Life" together with David Ficker and Terrence J. O'Brien (Wiley-Blackwell, 2015), and is co-author of a new book, "The Prescriber's Guide to Antiepileptic Drugs, Third Edition" with Philip Patsolos (Cambridge University Press, 2017). Dr. St. Louis Guest Edited Continuum: Sleep Neurology 2017 and co-edited Continuum: Epilepsy 2013 with Dr. Gregory Cascino.. For more information about Dr. St. Louis' activities, publications, and The Mayo Sleep and Cognitive Neurophysiology Laboratory please see: LinkedIn; Google Scholar; and Dr. St. Louis' research profile.

  1. Epilepsy
  2. Hypersomnia
  3. Narcolepsy
  4. Obstructive sleep apnea
  5. Parasomnia
  6. REM behavior disorder
  7. Restless legs syndrome
  8. Sleep apnea
  9. Sleep conditions
  • REM sleep behavior disorder and parasomnias
  • Sleep medicine
  • Epilepsy
  • General neurology
  1. 2014
    MS - (Clinical Investigation)The University of Iowa College of Public Health
  2. 1998
    Resident - Epilepsy/Clinical Neurophysiology FellowshipMayo Graduate School of Medicine, Mayo Clinic College of Medicine
  3. 1997
    Resident - Neurology ResidencyMayo Graduate School of Medicine, Mayo Clinic College of Medicine
  4. 1994
    Resident - Preliminary Medicine ResidencyMayo Graduate School of Medicine, Mayo Clinic College of Medicine
  5. 1993
    MDMedical College of Wisconsin
  6. 1989
    BA - Biology/ReligionSt. Olaf College


  1. 2013
    EpilepsyAmerican Board of Psychiatry and Neurology
  2. 2008
    Vascular NeurologyAmerican Board of Psychiatry and Neurology
  3. 2007
    Sleep MedicineAmerican Board of Psychiatry and Neurology
  4. 2004
    Sleep MedicineAmerican Board of Sleep Medicine
  5. 2001
    Clinical NeurophysiologyAmerican Board of Psychiatry and Neurology
  6. 2000
    Epilepsy MonitoringAmerican Board of Clinical Neurophysiology
  7. 1998
    NeurologyAmerican Board of Psychiatry and Neurology


Research activities

See a description of research activities.