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Jacob J. Orme, M.D., Ph.D.

  1. Oncologist

Jacob Orme, M.D., Ph.D., is a genitourinary medical oncologist and translational physician scientist who works in the clinic and the laboratory to make cancer care better for his patients. Dr. Orme discovered the source and consequence of soluble PD-L1 in immunotherapy-resistant cancers as well as a novel biomarker "switch" in advanced highly-resistant prostate cancers. These discoveries have led to the development of multiple new experimental therapeutics and clinical trials. Dr. Orme has received awards from Mayo Clinic, the Minnesota Society of Clinical Oncology, the National Institutes of Health, and the Prostate Cancer Foundation to support his work.

  1. PSMA therapy
  • Cancer treatment resistance mechanisms
  • Novel therapies for the cure of "incurable" malignancies
  • Helping patients with cancer live longer and better lives
  1. 2022
    FellowHematology/Oncology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  2. 2019
    ResidentInternal Medicine, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  3. 2016
    MD / PhD - Immunology (PhD)University of Texas Southwestern Medical Center

Certifications

  1. 2022
    Medical OncologyAmerican Board of Internal Medicine
  2. 2019
    Internal MedicineAmerican Board of Internal Medicine

Awards and honors

  1. 2025
    Director’s New Innovator Award FinalistNIH
  2. 2025
    Arnold and Kit Palmer Award for Cancer ResearchMayo Clinic Comprehensive Cancer Center
  3. 2024
    New Investigator Pilot Award, Eagles 5th District Cancer TelethonMayo Clinic Comprehensive Cancer Center
  4. 2024
    Competitive LRP FellowshipNIH
  5. 2024
    Top Performing Provider Patient Experience AwardMayo Clinic
  6. 2023
    Donald C. Balfour Award for Meritorious ResearchMayo Clinic
  7. 2023
    Top Performing Provider Patient Experience AwardMayo Clinic
  8. 2022
    Eustace Wolfington Young Investigator Award (YIA)Prostate Cancer Foundation (PCF)
  9. 2022
    Excellence Through Teamwork AwardMayo Clinic
  10. 2022
    Top Performing Provider Patient Experience AwardMayo Clinic
  11. 2022
    Innovator Accelerator Award (IIA)Mayo Clinic Office of Translation to Practice
  12. 2021
    Outstanding Fellow AwardThe Minnesota Society of Clinical Oncology
  13. 2021
    ImmunoOncology Young Investigator ForumSociety for Immunotherapy of Cancer (SITC)
  14. 2021
    Competitive LRP FellowshipNIH
  15. 2019
    Competitive LRP FellowshipNIH
  16. 2016
    Gold Humanism AwardUniversity of Texas Southwestern Medical Center
  17. 2012
    Competitive T32 Training Fellowship AwardNIH
  18. 2009
    University Honors Program GraduateBrigham Young University
  19. 2009
    Magna Cum LaudeBrigham Young University
  20. 2008
    ORCA ScholarBrigham Young University
  21. 2003
    Heritage ScholarBrigham Young University

Professional memberships

  1. 2024 - present
    MemberMayo Clinic Clinical Trial Transformation Task Force
  2. 2024 - present
    MemberHematology/Oncology Fellowship Selection Committee, Department of Oncology
  3. 2024 - present
    InterviewerInternal Medicine Residency Interview Committee, Department of Internal Medicine
  4. 2023 - present
    Alternate MemberTumor Board
  5. 2022 - 2023
    Commiittee MemberSociety of Basic Urologic Research
  6. 2021 - 2022
    MemberOncology Division Research Committee
  7. 2019 - 2021
    MemberHematology Practice Committee
  8. 2019 - present
    MemberComprehensive Cancer Center Implementation Team 5
  9. 2019 - present
    MemberMayo Clinic Cancer Center, Early Cancer Therapeutics Disease Group
  10. 2019 - present
    MemberSociety for Immunotherapy of Cancer
  11. 2018 - present
    MemberAmerican Association for Cancer Research
  12. 2017 - present
    MemberAmerican Society of Clinical Oncology
  13. 2016 - present
    MemberGold Humanism Honor Society
  14. 2012 - present
    MemberAmerican Physician Scientists Association (APSA)
  15. 2012 - present
    MemberAmerican Association of Immunologists

Publications

Research activities

See a description of research activities.