DepartmentsOncology (Medical)LocationRochester, MinnesotaLanguagesEnglishGermanExisting patientsSend a secure message via patient portal Biographical summaryJacob Orme, M.D., Ph.D., is a genitourinary medical oncologist and translational physician scientist who works in the clinic and the laboratory to make cancer care better for his patients. Dr. Orme discovered the source and consequence of soluble PD-L1 in immunotherapy-resistant cancers as well as a novel biomarker "switch" in advanced highly-resistant prostate cancers. These discoveries have led to the development of multiple new experimental therapeutics and clinical trials. Dr. Orme has received awards from Mayo Clinic, the Minnesota Society of Clinical Oncology, the National Institutes of Health, and the Prostate Cancer Foundation to support his work. Conditions treatedBladder cancerKidney cancerProstate cancerRenal cell carcinomaTesticular cancer InterestsCancer treatment resistance mechanismsNovel therapies for the cure of "incurable" malignanciesHelping patients with cancer live longer and better lives Mayo Clinic locations Rochester, Minnesota Driving directions More info Billing & insurance Accessibility services Education2022FellowHematology/Oncology, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine2019ResidentInternal Medicine, Programs in Rochester, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine2016MD / PhD - Immunology (PhD)University of Texas Southwestern Medical CenterShow more education Activities and honorsCertifications2022Medical OncologyAmerican Board of Internal Medicine2019Internal MedicineAmerican Board of Internal MedicineAwards and honors2023Donald C. Balfour Award for Meritorious ResearchMayo Clinic2022Young Investigator AwardProstate Cancer Foundation (PCF)2022Excellence Through Teamwork AwardMayo Clinic2022Top Performing Provider Patient Experience AwardMayo Clinic2021Outstanding Fellow AwardThe Minnesota Society of Clinical Oncology2016Gold Humanism AwardUniversity of Texas Southwestern Medical CenterShow more awards and honorsPublicationsSee my publicationsResearch activitiesSee a description of research activities. Biographical summaryConditions treatedInterestsMayo Clinic locationsEducationActivities and honors Request an appointment PST-20543127 Doctors & Medical Staff Orme, Jacob J. M.D., Ph.D.