Interactions with Drugs
Arginine may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
Arginine may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
Arginine may change blood sugar levels. Caution is advised when using medications that may affect blood sugar levels. People taking insulin or drugs for diabetes by mouth should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
Arginine may also interact with ACE (angiotensin-converting enzyme) inhibitors, agents for pain or for the heart, agents that affect the nervous system, agents that increase potassium levels (including angiotensin II receptor antagonists and heparin), agents that decrease the immune system, agents used to treat blood disorders, aminophylline, antacids, antibiotics, anticancer agents, anti-inflammatories, antimalarials, antiobesity agents, antiseizure agents, aspirin, cardiac glycosides, cholesterol-lowering agents, contraceptives (birth control), cyclophosphamide, cyclosporine, diuretics, estrogens, glucagon, growth hormones, H2 blockers, insulin, iron salts, isoproterenol, nicotine, nitrates, nitroderivatives, phenylephrine, phosphodiesterase inhibitors, potassium salts, progestin, propofol, proton pump inhibitors, sertraline, spironolactone, and stomach and intestinal agents.
Interactions with Herbs and Dietary Supplements
Arginine may lower blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
Arginine may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Arginine may change blood sugar levels. Caution is advised when using herbs or supplements that may also change blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
Arginine may also interact with antacids; antibacterials; anticancer herbs and supplements; anti-inflammatories; antimalarials; antioxidants; athletic performance enhancers; branched chain amino acids; cardiac glycosides; cholesterol-lowering herbs and supplements; citrulline; conjugated linoleic acid (CLA); creatine; diuretics; gingko; green tea extract; herbs and supplements for the heart, obesity, pain, or seizures; herbs and supplements that affect the nervous system or reduce immune function; hormonal herbs and supplements; iron; lysine; magnesium; N-acetyl cysteine; omega-3 fatty acids; ornithine; phytoestrogens; pine bark extract; piplartine; Pycnogenol®; sodium; stomach and intestinal herbs and supplements; vitamin C; vitamin E; wound healing herbs and supplements; xylitol; and yohimbine.
This evidence-based monograph was prepared by The Natural Standard Research Collaboration