Thomas J. Byrne, M.D.

Thomas J. Byrne, M.D., is a gastroenterologist and transplant hepatologist at Mayo Clinic in Phoenix, Arizona. He specializes in the evaluation and treatment of complex liver diseases, advanced liver conditions and liver transplantation, providing comprehensive care for patients with acute and chronic liver disease.

Dr. Byrne cares for patients with cirrhosis, metabolic dysfunction-associated steatotic liver disease (MASLD), alcoholic hepatitis, hepatic encephalopathy, hepatocellular carcinoma and other hepatobiliary disorders. As a member of Mayo Clinic’s Liver Transplant Program and Hepatobiliary Clinic, he collaborates with multidisciplinary experts to deliver individualized, evidence-based treatment plans.

Dr. Byrne is board-certified in Gastroenterology and Transplant Hepatology by the American Board of Internal Medicine. He completed fellowship training in Gastroenterology, Hepatology and Transplantation Medicine at Scripps Clinic in La Jolla, California, and completed his Internal Medicine residency through Mayo Clinic School of Graduate Medical Education in Arizona.

His clinical interests include fatty liver disease and hepatocellular carcinoma. In addition to managing complex liver conditions, Dr. Byrne performs gastrointestinal procedures including colonoscopy and upper endoscopy. He works closely with patients to help them understand their diagnosis and treatment options while supporting long-term liver health.

As part of Mayo Clinic’s integrated practice, Dr. Byrne partners with specialists across disciplines to provide coordinated care for patients requiring advanced hepatology and liver transplant expertise.