Mayo Clinic's approach


Mayo Clinic joined with medical centers across the U.S. to collect plasma from people who had recovered from COVID-19. Mayo Clinic coordinated this government-sponsored program.

Team approach

Mayo doctors from many areas work together to study potential treatments for COVID-19. Team member specialties include:

  • Infectious diseases.
  • Laboratory medicine and pathology.
  • Blood collection and testing (transfusion medicine).
  • Pharmacy.
  • Virus studies (virology).
  • Cardiovascular diseases.
  • Primary Care.
  • Department of Nursing.
  • Department of Pharmacy.
  • Infusion Therapy Centers.


Mayo Clinic researchers are studying the virus that causes COVID-19 and how it affects the immune system. They're studying drugs and treatments for COVID-19 as well as working on diagnostic and antibody tests. Researchers are active in clinical trials for COVID-19 and other infectious diseases.

July 21, 2023
  1. Investigational COVID-19 convalescent plasma. U.S. Food and Drug Administration. Accessed May 2, 2023.
  2. Hoffman R, et al. Principles of plasma and plasma derivatives. In: Hematology. 8th edition. Elsevier. 2023. Accessed May 2, 2023.
  3. Marano G, et al. Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion. 2016; doi:10.2450/2015.0131-15.
  4. Emergency use authorization. U.S. Food and Drug Administration. Accessed May 2, 2023.
  5. AskMayoExpert. Convalescent Plasma. Mayo Clinic; 2023.
  6. COVID-19 convalescent plasma. National Institutes of Health. Accessed May 2. 2023.
  7. Rajendran K, et al. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. Journal of Medical Virology. 2020; doi:10.1002/jmv.25961.
  8. Senefeld JW, et al. COVID-19 Convalescent plasma for the treatment of immunocompromised patients: A systematic review and meta-analysis. Journal of the American Medical Association: Network Open. 2023; doi:10.1001/jamanetworkopen.2022.50647.
  9. COVID-19 treatments and medications. Centers for Disease Control and Prevention. Accessed May 2, 2023.
  10. Kim AR. Coronavirus disease 2019 (COVID-19): Management in hospitalized adults. Accessed May 2, 2023.
  11. Infectious disease, HLA and ABO donor qualification testing. American Red Cross. Accessed May 3, 2023.
  12. Tulledge-Scheitel, S (expert opinion). Mayo Clinic. May 5, 2023.

Convalescent plasma therapy