Search Results 1-10 of 15976 for Tumor+suppressor+gene

  1. Cancer - Symptoms and causes - Mayo Clinic

    A mutation in a tumor suppressor gene allows cancer cells to continue growing and accumulating. Make mistakes when repairing DNA errors. DNA repair genes look ...

  2. Mayo Clinic Uncovers a Crucial Tumor Suppression Function of p53, the Most Commonly Mutated Gene in Human Cancers

    ROCHESTER, Minn. — April 24, 2014 — Mayo Clinic researchers have uncovered a novel tumor suppressive role for p53, a cancer-critical gene that is mutated in ...

  3. Discovery's Edge: Battling brain cancers through genomics - Mayo Clinic News Network

    Tumor suppressor genes are the brakes: when they are faulty cells continue to divide even when they should stop. Caretaker genes play the part of mechanic ...

  4. Renal Cancer: A Paradigm for Understanding How Mutations in Epigenetic Regulator Genes Drive Cancer Initiation and Progression - Research - Mayo Clinic Research

    ... gene mutations (including SETD2, PBRM1 and BAP1) while presenting with relatively low mutation frequency of traditional tumor suppressor genes such as p53.

  5. Mayo Clinic Uncovers How One Gene, Protein Suppresses Tumor Formation

    — Pten (short for phosphatase and tensin homolog) is a tumor suppressor that is defective in about 20-25 percent of all patients with cancers. Mayo Clinic ...

  6. Tumor Molecular Analysis - Mayo Clinic

    Molecular characterization may include short tandem DNA repeat; STR) and oncogenic/tumor suppressor gene mutation analyses to assure that the derived models ...

  7. Epigenetic Pharmacology - Research - Mayo Clinic Research

    For example, 5-azadC is known to inhibit DNA methyltransferases and in dividing cells lead to demethylation of aberrantly hypermethylated tumor suppressor genes ...

  8. Cancer-Causing Gene Alone Doesn't Trigger Pancreatic Cancer, Mayo-led Study Finds

    They further found that in mice that had lost expression of the TP53 tumor suppressor — a situation that mirrors up to 60 percent of human pancreatic cancer ...

  9. Mayo Clinic Researchers Say Gene in Brain Linked to Kidney Cancer

    ... genes to see the effect on tumor ... D., a cancer biologist, then searched for prevalence of the NPTX2 gene in kidney cancer ... inhibitor, when one is developed.

  10. Mayo-led research team identifies genes that increase risk for triple-negative breast cancer

    3D image of BRCA2 breast cancer susceptibility gene 2 tumor suppressor bound to DSS1 ... They tested 21 cancer predisposition genes in 8,753 patients and 17 genes ...