Search Results 21-30 of 15188 for Proto-oncogene

  1. Renal Cancer: A Paradigm for Understanding How Mutations in Epigenetic Regulator Genes Drive Cancer Initiation and Progression - Research - Mayo Clinic Research

    The Epigenetic Etiology of Human Disease Laboratory at Mayo Clinic is studying epigenetic mutations at the epigenome and transcriptome levels.

  2. Tumor Molecular Analysis - Mayo Clinic

    Molecular characterization may include short tandem DNA repeat; STR) and oncogenic/tumor suppressor gene mutation analyses to assure that the derived models ...

  3. Uncovering Signaling Pathways That Regulate Invasion and Metastasis of Cancer Cells - Tumor Development, Immunology and Progression Laboratory - Mayo Clinic Research

    While PKD1 mediates cell proliferation and also acts as a suppressor of breast tumor cell invasion, PKD3, when expressed, mediates all oncogenic functions.

  4. Beating Advanced Cancers: New Epigenomic Block for Advanced Cancer Progression - Mayo Clinic News Network

    The precision medicine study appears online in Oncogene and focuses on kidney cancer and its metastases. Recent studies of the same epigenomic fingerprint ...

  5. Cancer-Causing Gene Alone Doesn't Trigger Pancreatic Cancer, Mayo-led Study Finds

    The study, published in the Sept. 10 issue of Cancer Cell, overturns the current belief that a mutation in the KRAS oncogene is enough to initiate pancreatic ...

  6. Mayo Clinic Researchers Identify Gene that Pushes Normal Pancreas Cells to Change Shape, a Key Step to Cancer Development

    However, the presence of oncogenic signaling (Kras mutations, EGF-R) can push these duct cells to develop lesions that are at risk for tumor development. To ...

  7. Transgenic and Knockout Core - Mayo Clinic Comprehensive Cancer Center Research

    Transgenic and gene-targeted mouse models enable Mayo Clinic cancer researchers to study in vivo how the overexpression of specific genes and their mutants is ...

  8. Overview - Cancer Biology and Translational Research - Mayo Clinic Research

    Overview · Describing a paradigm shift for the tumor suppressor FoxO3a, whereby our research team identified a new oncogenic role promoting tumor growth ...

  9. Genomic and Proteomic Analyses of Aggressive Tumors - Mayo Clinic

    About this study. The purpose of this study is to use genomic and proteomic analyses to identify possible diagnostic markers and potential drugs for ...

  10. Uncovering the Signaling Events Underlying the Development and Progression of Pancreatic Cancer - Tumor Development, Immunology and Progression Laboratory - Mayo Clinic Research

    The lab team has confirmed activation of this signaling pathway by oncogenic KRas as a key event driving the development of pancreatic cancer. The lab's ...