Search Results 1-5 of 5 for Adhesion

1. Defactinib Combined With Pembrolizumab and Gemcitabine in Patients With Advanced Cancer - Mayo Clinic

   Focal adhesion kinase (FAK) pathway activation is essential for promoting a fibrotic and inflammatory tumor microenvironment, and FAK inhibitors have demonstrated reasonable anti-tumor activity in the preclinical setting.

2. Mayo Clinic

   The abnormal secretion of ECM proteins stems from the inability of c-Src overexpressing cells to sense their environment and to act in-sync with local tissue demand, likely because of a constitutive activation of ECM biosensors such as focal adhesion...

3. A Study Using Targeted Inhibitors to Treat Specific Tumor Mutations in Patients with Meningiomas - Mayo Clinic

   Study IDs Site IRB Jacksonville, Florida: 15-006775 Rochester, Minnesota: 15-006775 Scottsdale/Phoenix, Arizona: 15-006775 NCT ID: NCT02523014 Sponsor Protocol Number: A071401 About this study This phase II trial studies how well vismodegib and focal...

4. Participation in a Research Registry for Immune Disorders - Mayo Clinic

   These immune deficiency diseases are thought to be rare and include: Severe combined immunodeficiency (SCID), leukocyte adhesion deficiency (LAD), X-linked Agammaglobulinemia (XLA), common variable immune deficiency (CVID), DiGeorge ...

5. Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer - Mayo Clinic

   Our studies demonstrate that RB deficiency altered the expression of key molecules needed for proper cellular organization and epithelial cell-cell adhesion as part of a program related to the epithelial-to-mesenchymal transition (EM...