Search Results 21-30 of 16474 for Proto-oncogene

  1. Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast Cancer

    The neu (c-erbB-2) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. Herein, cyclin D1 protein ...

  2. Clinical trials - Oncology (Medical)

    Molecular characterization may include short tandem DNA repeat; STR) and oncogenic/tumor suppressor gene mutation analyses to assure that the derived models ...

  3. Publications - Ruth Lupu, Ph.D. - Mayo Clinic

    Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. Histol Histopathol. 2017 Jul; 32 (7):687-698 Epub ...

  4. Uncovering Signaling Pathways That Regulate Invasion and Metastasis of Cancer Cells - Tumor Development, Immunology and Progression Laboratory - Mayo Clinic Research

    While PKD1 mediates cell proliferation and also acts as a suppressor of breast tumor cell invasion, PKD3, when expressed, mediates all oncogenic functions.

  5. Publications - Erik C. Thorland, Ph.D. - Mayo Clinic

    Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors. Oncogene. 2002 Oct ...

  6. Patient Derived Preclinical Models - Mayo Clinic

    Guidance for molecular targeted therapy will involve gene analysis of oncogenes and tumor suppressor genes. Results from these studies may provide the ...

  7. A Study Evaluating Fecal DNA Markers to Detect Colorectal Neoplasia in Patients with Inflammatory Bowel Disease - Mayo Clinic

    Cells with increased oncogene activity adopt a secretory phenotype. For example, increased levels of c-Src not only inhibit differentiation but also induce ...

  8. More Mayo neuroscience: Brain cells 'crosstalk' and cancer growth; Preoperative radiotherapy survival; Rare mutation causes memory loss

    Mayo Clinic researchers have made advances in neuroscience discoveries including glioblastoma, an aggressive type of brain cancer, and CSF1R-Related ...

  9. Tumor Microenvironment - Department of Cancer Biology - Mayo Clinic Research

    Dr. Ji's team developed experimental systems that specifically target oncogenes and tumor suppressors in the cells of interest. These systems can be used to ...

  10. Overview - Molecular Mechanisms of Tumorigenesis: Verline Justilien - Mayo Clinic Research

    In her Molecular Mechanisms of Tumorigenesis Lab at Mayo Clinic, Verline Justilien, Ph.D., hopes to identify oncogenic drivers of lung cancer and pancreas ...