Publications Print Steen TV, Espinoza I, Duran C, Casadevall G, Serrano-Hervas E, Cuyas E, Verdura S, Kemble G, Kaufmann SH, McWilliams R, Osuna S, Billadeau DD, Menendez JA, Lupu R. Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer. Neoplasia. 2025 Apr; 62:101143 Epub 2025 Feb 24 View PubMed Lopez J, Llop-Hernandez A, Verdura S, Serrano-Hervas E, Martinez-Balibrea E, Bosch-Barrera J, Teixidor E, Lopez-Bonet E, Martin-Castillo B, Sardanyes J, Alarcon T, Lupu R, Cuyas E, Menendez JA. Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies. Cell Death Discov. 2025 Mar 7; 11 (1):91 Epub 2025 Mar 07 View PubMed Cuyas E, Pedarra S, Verdura S, Pardo MA, Espin Garcia R, Serrano-Hervas E, Llop-Hernandez A, Teixidor E, Bosch-Barrera J, Lopez-Bonet E, Martin-Castillo B, Lupu R, Pujana MA, Sardanyes J, Alarcon T, Menendez JA. Fatty acid synthase (FASN) is a tumor-cell-intrinsic metabolic checkpoint restricting T-cell immunity. Cell Death Discov. 2024 Sep 30; 10 (1):417 Epub 2024 Sept 30 View PubMed Menendez JA, Cuyàs E, Encinar JA, Vander Steen T, Verdura S, Llop-Hernández À, López J, Serrano-Hervás E, Osuna S, Martin-Castillo B, Lupu R. Fatty acid synthase (FASN) signalome: A molecular guide for precision oncology. Mol Oncol. 2024 Mar; 18(3):479-516. Epub 2024 Jan 18. View PubMed Cuyas E, Fernandez-Arroyo S, Verdura S, Lupu R, Joven J, Menendez JA. Metabolomic and Mitochondrial Fingerprinting of the Epithelial-to-Mesenchymal Transition (EMT) in Non-Tumorigenic and Tumorigenic Human Breast Cells. Cancers (Basel). 2022 Dec 16; 14 (24) View PubMed Drawz PE, DeSilva M, Bodurtha P, Vazquez Benitez G, Murray A, Chamberlain AM, Dudley RA, Waring S, Kharbanda AB, Murphy D, Muscoplat MH, Melendez V, Margolis KL, McFarling L, Lupu R, Winkelman TNA, Johnson SG. Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2-Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record Consortium. Clin Infect Dis. 2022 Sep 14; 75 (5):890-892 View PubMed Menendez JA, Lupu R. Fatty acid synthase: a druggable driver of breast cancer brain metastasis. Expert Opin Ther Targets. 2022 May; 26 (5):427-444 Epub 2022 May 19 View PubMed Espinoza I, Yang L, Steen TV, Vellon L, Cuyas E, Verdura S, Lau L, Menendez JA, Lupu R. Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin alpha6beta1 drives endocrine resistance in breast cancer cells. Aging (Albany NY). 2022 Feb 11; 14 (3):1200-1213 View PubMed Yang L, Vander Steen T, Espinoza I, Cuyàs E, Verdura S, Menendez JA, Lupu R. Nuclear moonlighting of the secreted growth factor heregulin drives endocrine-resistant breast cancer independently of HER2/HER3 signaling. Am J Cancer Res. 2022; 12(5):2173-2188. Epub 2022 May 15. View PubMed Espinoza I, Kurapaty C, Park CH, Vander Steen T, Kleer CG, Wiley E, Rademaker A, Cuyàs E, Verdura S, Buxó M, Reynolds C, Menendez JA, Lupu R. Depletion of CCN1/CYR61 reduces triple-negative/basal-like breast cancer aggressiveness. Am J Cancer Res. 2022; 12(2):839-851. Epub 2022 Feb 15. View PubMed Schroeder B, Vander Steen T, Espinoza I, Venkatapoorna CMK, Hu Z, Silva FM, Regan K, Cuyàs E, Meng XW, Verdura S, Arbusà A, Schneider PA, Flatten KS, Kemble G, Montero J, Kaufmann SH, Menendez JA, Lupu R. Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells. Cell Death Dis. 2021 Oct 21; 12(11):977. View PubMed Menendez JA, Papadimitropoulou A, Vander Steen T, Cuyàs E, Oza-Gajera BP, Verdura S, Espinoza I, Vellon L, Mehmi I, Lupu R. Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer. Cancers (Basel). 2021 Mar 06; 13(5). View PubMed Menendez JA, Peirce SK, Papadimitropoulou A, Cuyàs E, Steen TV, Verdura S, Vellon L, Chen WY, Lupu R. Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer. Aging (Albany NY). 2020 Dec 10; 12(24):24671-24692. View PubMed Papadimitropoulou A, Vellon L, Atlas E, Steen TV, Cuyàs E, Verdura S, Espinoza I, Menendez JA, Lupu R. Heregulin Drives Endocrine Resistance by Altering IL-8 Expression in ER-Positive Breast Cancer. Int J Mol Sci. 2020 Oct 19; 21(20). View PubMed Menendez JA, Mehmi I, Papadimitropoulou A, Vander Steen T, Cuyàs E, Verdura S, Espinoza I, Vellon L, Atlas E, Lupu R. Fatty Acid Synthase Is a Key Enabler for Endocrine Resistance in Heregulin-Overexpressing Luminal B-Like Breast Cancer. Int J Mol Sci. 2020 Oct 16; 21(20). View PubMed Cuyas E, Verdura S, Martin-Castillo B, Alarcon T, Lupu R, Bosch-Barrera J, Menendez JA. Tumor Cell-Intrinsic Immunometabolism and Precision Nutrition in Cancer Immunotherapy. Cancers (Basel). 2020 Jul 2; 12 (7) Epub 2020 July 02 View PubMed Jung MY, Kang JH, Hernandez DM, Yin X, Andrianifahanana M, Wang Y, Gonzalez-Guerrico A, Limper AH, Lupu R, Leof EB. Fatty acid synthase is required for profibrotic TGF-ß signaling. FASEB J. 2018 Jul; 32(7):3803-3815. Epub 2018 Feb 16. View PubMed Corominas-Faja B, Cuyas E, Lozano-Sanchez J, Cufi S, Verdura S, Fernandez-Arroyo S, Borras-Linares I, Martin-Castillo B, Martin AG, Lupu R, Nonell-Canals A, Sanchez-Martinez M, Micol V, Joven J, Segura-Carretero A, Menendez JA. Extra-virgin olive oil contains a metabolo-epigenetic inhibitor of cancer stem cells. Carcinogenesis. 2018 Apr 5; 39 (4):601-613 View PubMed Menendez JA, Lupu R. Fatty acid synthase (FASN) as a therapeutic target in breast cancer. Expert Opin Ther Targets. 2017 Nov; 21 (11):1001-1016 Epub 2017 Sept 21 View PubMed Corominas-Faja B, Vellon L, Cuyas E, Buxo M, Martin-Castillo B, Serra D, Garcia J, Lupu R, Menendez JA. Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. Histol Histopathol. 2017 Jul; 32 (7):687-698 Epub 2016 Oct 07 View PubMed Haddad T, Qin R, Lupu R, Satele D, Eadens M, Goetz MP, Erlichman C, Molina J. A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2017 Jun; 79 (6):1221-1227 Epub 2017 May 05 View PubMed Cuyas E, Corominas-Faja B, Martin MM, Martin-Castillo B, Lupu R, Brunet J, Bosch-Barrera J, Menendez JA. BRCA1 haploinsufficiency cell-autonomously activates RANKL expression and generates denosumab-responsive breast cancer-initiating cells. Oncotarget. 2017 May 23; 8 (21):35019-35032 View PubMed Menendez JA, Lupu R. Fatty acid synthase regulates estrogen receptor-alpha signaling in breast cancer cells. Oncogenesis. 2017 Feb 27; 6 (2):e299 View PubMed Colomer R, Sarrats A, Lupu R, Puig T. Natural polyphenols and their synthetic analogs as emerging anticancer agents Current Drug Targets. 2017; 18: (2)147-59. Gonzalez-Guerrico AM, Espinoza I, Schroeder B, Park CH, Kvp CM, Khurana A, Corominas-Faja B, Cuyas E, Alarcon T, Kleer C, Menendez JA, Lupu R. Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer. Oncotarget. 2016 Nov 1; 7 (44):71151-71168 View PubMed Cuyas E, Fernandez-Arroyo S, Alarcon T, Lupu R, Joven J, Menendez JA. Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers. Oncotarget. 2016 Aug 16; 7 (33):52974-52992 View PubMed Menendez JA, Vellon L, Espinoza I, Lupu R. The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells. Oncoscience. 2016; 3 (7-8):242-257 Epub 2016 July 22 View PubMed Menendez JA, Rubio MA, Campisi J, Lupu R. Heregulin, a new regulator of telomere length in human cells. Oncotarget. 2015 Nov 24; 6 (37):39422-36 View PubMed Menendez JA, Benboudjema L, Vellon L, Rubio MA, Espinoza I, Campisi J, Lupu R. Heregulin, a new interactor of the telosome/shelterin complex in human telomeres. Oncotarget. 2015 Nov 24; 6 (37):39408-21 View PubMed Menendez JA, Schroeder B, Peirce SK, Vellon L, Papadimitropoulou A, Espinoza I, Lupu R. Blockade of a key region in the extracellular domain inhibits HER2 dimerization and signaling. J Natl Cancer Inst. 2015 Jun; 107(6):djv090. Epub 2015 Apr 16. View PubMed Espinoza I, Menendez JA, Kvp CM, Lupu R. CCN1 promotes vascular endothelial growth factor secretion through alphavbeta 3 integrin receptors in breast cancer. J Cell Commun Signal. 2014 Mar; 8 (1):23-7 Epub 2013 Dec 12 View PubMed Khurana A, Gonzalez-Guerrico A, Lupu R. Heregulin in breast cancer: old story, new paradigm. Curr Pharm Des. 2014; 20 (30):4874-8 View PubMed Corominas-Faja B, Cufi S, Oliveras-Ferraros C, Cuyas E, Lopez-Bonet E, Lupu R, Alarcon T, Vellon L, Iglesias JM, Leis O, Martin AG, Vazquez-Martin A, Menendez JA. Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway. Cell Cycle. 2013 Sep 15; 12(18):3109-24. Epub 2013 Aug 21. View PubMed Vazquez-Martin A, Corominas-Faja B, Cufi S, Vellon L, Oliveras-Ferraros C, Menendez OJ, Joven J, Lupu R, Menendez JA. The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells. Cell Cycle. 2013 Jan 15; 12(2):207-18. Epub 2012 Jan 15. View PubMed Espinoza I Menendez JA Chandra Mohan Kurapaty Venkatapoorna, Lupu R. CYR61 induces Vascular Endothelial Growth Factor (VEGF) secretion through αvβ3 integrin receptor in Breast Cancer. Journal of Cell Communication and Signaling. 2013. Lupu-Meiri M, Geras-Raaka E, Lupu R, Shapira H, Sandbank J, Segal L, Gershengorn MC, Oron Y. Knock-down of plasminogen-activator inhibitor-1 enhances expression of E-cadherin and promotes epithelial differentiation of human pancreatic adenocarcinoma cells. J Cell Physiol. 2012 Nov; 227(11):3621-8. View PubMed Jang JS, Jeon HS, Sun Z, Aubry MC, Tang H, Park CH, Rakhshan F, Schultz DA, Kolbert CP, Lupu R, Park JY, Harris CC, Yang P, Jen J. Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin Cancer Res. 2012 Jul 1; 18 (13):3658-67 Epub 2012 May 09 View PubMed Eldar-Boock A, Miller K, Sanchis J, Lupu R, Vicent MJ, Satchi-Fainaro R. Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel. Biomaterials. 2011 May; 32(15):3862-74. Epub 2011 Mar 04. View PubMed Espinoza I, Liu H, Busby R, Lupu R. CCN1, a candidate target for zoledronic acid treatment in breast cancer. Mol Cancer Ther. 2011 May; 10 (5):732-41 Epub 2011 Mar 10 View PubMed Marra M, Santini D, Meo G, Vincenzi B, Zappavigna S, Baldi A, Rosolowski M, Tonini G, Loeffler M, Lupu R, Addeo SR, Abbruzzese A, Budillon A, Caraglia M. Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells. Int J Cancer. 2009 Nov 1; 125(9):2004-13. View PubMed Grunt TW, Wagner R, Grusch M, Berger W, Singer CF, Marian B, Zielinski CC, Lupu R. Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells. Biochem Biophys Res Commun. 2009 Jul 31; 385(3):454-9. Epub 2009 May 23. View PubMed Deshet N, Lupu-Meiri M, Espinoza I, Fili O, Shapira Y, Lupu R, Gershengorn MC, Oron Y. Plasminogen-induced aggregation of PANC-1 cells requires conversion to plasmin and is inhibited by endogenous plasminogen activator inhibitor-1. J Cell Physiol. 2008 Sep; 216(3):632-9. View PubMed Lupu R, Colomer R, Menendez JA. An easy, rapid and objective mathematical method to identify fatty acid synthase (oncogenic antigen-519) modulators with potential anticancer value. Clin Transl Oncol. 2008 Apr; 10(4):219-26. View PubMed Vazquez-Martin A, Colomer R, Brunet J, Lupu R, Menendez JA. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif. 2008 Feb; 41(1):59-85. View PubMed Colomer R, Lupu R, Papadimitropoulou A, Vellon L, Vazquez-Martin A, Brunet J, Fernandez-Gutierrez A, Segura-Carretero A, Menendez JA. Giacomo Castelvetro's salads. Anti-HER2 oncogene nutraceuticals since the 17th century? Clin Transl Oncol. 2008 Jan; 10(1):30-4. View PubMed Vellon L, Menendez JA, Liu H, Lupu R. Up-regulation of alphavbeta3 integrin expression is a novel molecular response to chemotherapy-induced cell damage in a heregulin-dependent manner. Differentiation. 2007 Nov; 75(9):819-30. View PubMed Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 2007 Oct; 7(10):763-77. View PubMed Menendez JA, Vellon V, Oza B, Lupu R. The angiogenic inducer CYR61 synergistically enhances Heregulin-stimulated secretion of Vascular Endothelial Growth Factor (VEGF) via αvβ3 integrin receptor: A novel therapeutic target for Small peptidomimetic αvβ3 integrin antagonists. Differentiation. 2007. Menendez JA, Oza BP, Lupu R. Fatty Acid Synthase (FAS) gene expression and FAS-catalyzed de novo fatty acid biosynthesis is necessary for estrogen-stimulated breast cancer cell proliferation and survival. Journal of Endocrinology. 2007. Menendez JA, Lupu R. Mediterranean dietary traditions for the molecular treatment of human cancer: anti-oncogenic actions of the main olive oil's monounsaturated fatty acid oleic acid (18:1n-9). Curr Pharm Biotechnol. 2006 Dec; 7(6):495-502. View PubMed Lupu R, Menendez JA. Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol. 2006 Dec; 7(6):483-93. View PubMed Menendez JA, Vellon L, Lupu R. DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes. Int J Mol Med. 2006 Dec; 18(6):1081-7. View PubMed Menendez JA, Vazquez-Martin A, Ropero S, Colomer R, Lupu R. HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". Clin Transl Oncol. 2006 Nov; 8(11):812-20. View PubMed Vellon L, Menendez JA, Lupu R. A bidirectional "alpha(v)beta(3) integrin-ERK1/ERK2 MAPK" connection regulates the proliferation of breast cancer cells. Mol Carcinog. 2006 Oct; 45(10):795-804. View PubMed Menendez JA, Papadimitropoulou A, Vellon L, Lupu R. A genomic explanation connecting "Mediterranean diet", olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer. 2006 Oct; 42(15):2425-32. Epub 2006 Jan 06. View PubMed Lupu R, Menendez JA. Targeting fatty acid synthase in breast and endometrial cancer: An alternative to selective estrogen receptor modulators? Endocrinology. 2006 Sep; 147(9):4056-66. Epub 2006 Jun 29. View PubMed Menendez JA, Mehmi I, Lupu R. Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression. J Clin Oncol. 2006 Aug 10; 24(23):3735-46. Epub 2006 Jul 17. View PubMed Menendez JA, Lupu R. Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. Curr Opin Clin Nutr Metab Care. 2006 Jul; 9(4):346-57. View PubMed Menendez JA, Vellon L, Lupu R. The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells. Int J Gynecol Cancer. 2006 Jan-Feb; 16(1):219-21. View PubMed Menendez JA, Lupu R. Response: Effect of -Linolenic Acid on the Transcriptional Activity of the Her-2/neu (erbB-2) Oncogene. J Natl Cancer Inst. 2006; 98(10):718-20. Menendez JA, Vellon L, Colomer R, Lupu R. Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. J Natl Cancer Inst. 2005 Nov 2; 97(21):1611-5. View PubMed Menendez JA, Vellon L, Lupu R. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Ann Oncol. 2005 Aug; 16(8):1253-67. Epub 2005 May 03. View PubMed Menendez JA, Lupu R, Colomer R. Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. Drug News Perspect. 2005 Jul-Aug; 18(6):375-85. View PubMed Menendez JA, Lupu R, Colomer R. Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Eur J Cancer Prev. 2005 Jun; 14(3):263-70. View PubMed Menendez JA, Oza BP, Colomer R, Lupu R. The estrogenic activity of synthetic progestins used in oral contraceptives enhances fatty acid synthase-dependent breast cancer cell proliferation and survival. Int J Oncol. 2005 Jun; 26(6):1507-15. View PubMed Vellon L, Menendez JA, Lupu R. AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. 2005 May 26; 24(23):3759-73. View PubMed Menendez JA, Vellon L, Colomer R, Lupu R. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. Int J Cancer. 2005 May 20; 115(1):19-35. View PubMed Menendez JA, Vellon L, Oza BP, Lupu R. Does endogenous fatty acid metabolism allow cancer cells to sense hypoxia and mediate hypoxic vasodilatation? Characterization of a novel molecular connection between fatty acid synthase (FAS) and hypoxia-inducible factor-1alpha (HIF-1alpha)-related expression of vascular endothelial growth factor (VEGF) in cancer cells overexpressing her-2/neu oncogene. J Cell Biochem. 2005 Apr 1; 94(5):857-63. View PubMed Menendez JA, Vellon L, Lupu R. Orlistat: from antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors? Exp Biol Med (Maywood). 2005 Mar; 230: (3)151-4. View PubMed Menendez JA, Mehmi I, Lupu R. Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage. Int J Oncol. 2005 Mar; 26(3):649-59. View PubMed Menendez JA, Vellon L, Colomer R, Lupu R. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Ann Oncol. 2005 Mar; 16(3):359-71. Epub 2005 Jan 10. View PubMed Menendez JA, Vellon L, Mehmi I, Teng PK, Griggs DW, Lupu R. A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene. 2005 Jan 27; 24(5):761-79. View PubMed Menendez JA, Vellon L, Lupu R. Targeting fatty acid synthase-driven lipid rafts: a novel strategy to overcome trastuzumab resistance in breast cancer cells. Med Hypotheses. 2005; 64(5):997-1001. View PubMed Menendez JA, Colomer R, Lupu R. Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids? Med Hypotheses. 2005; 64(2):342-9. View PubMed Menendez JA, Colomer R, Lupu R. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. Med Hypotheses. 2005; 64(2):337-41. View PubMed Menendez JA, Lupu R. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells. Int J Mol Med. 2005 Jan; 15(1):33-40. View PubMed Menendez JA, Decker JP, Lupu R. In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cells. J Cell Biochem. 2005 Jan 1; 94(1):1-4. View PubMed Menendez JA, Lupu R. Fatty Acid Synthase is a novel regulator of Her-2/neu (erbB-2) oncogene in breast cancer cells. Tumor Microenvir: Progression, Therapy and Prevention.. 2005; S.r.l.: 29-41. Menendez JA, Lupu R. Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: from anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells. Arch Immunol Ther Exp (Warsz). 2004 Nov-Dec; 52: (6)414-26. View PubMed Menendez JA, Mehmi I, Verma VA, Teng PK, Lupu R. Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. Mol Carcinog. 2004 Nov; 41(3):164-78. View PubMed Menendez JA, Colomer R, Lupu R. Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells. Oncol Rep. 2004 Aug; 12(2):411-22. View PubMed Menendez JA, Vellon L, Mehmi I, Oza BP, Ropero S, Colomer R, Lupu R. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10715-20. Epub 2004 Jul 02. View PubMed Menendez JA, Oza BP, Atlas E, Verma VA, Mehmi I, Lupu R. Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells. Oncogene. 2004 Jun 17; 23(28):4945-58. View PubMed Menendez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. Int J Oncol. 2004 Jun; 24(6):1369-83. View PubMed Menendez JA, Ropero S, Lupu R, Colomer R. Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. Oncol Rep. 2004 Jun; 11(6):1241-52. View PubMed Menendez JA, Lupu R, Colomer R. Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere). Breast Cancer Res Treat. 2004 Mar; 84(2):183-95. View PubMed Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. Int J Oncol. 2004 Mar; 24(3):591-608. View PubMed Menendez JA, Ropero S, Lupu R, Colomer R. ω-6 Gamma-Linolenic fatty acid Enhances Docetaxel Cytotoxic in Human Breast Cancer Cells: Relationship to lipid peroxidation and HER-2 expression. Oncology Reports. 2004; 11(6):1241-52. Lupu R, Mehmi I, Atlas E, Tsai MS, Pisha E, Oketch-Rabah HA, Nuntanakorn P, Kennelly EJ, Kronenberg F. Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int J Oncol. 2003 Nov; 23(5):1407-12. View PubMed Menendez JA, Mehmi I, Griggs DW, Lupu R. The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives. Endocr Relat Cancer. 2003 Jun; 10(2):141-52. View PubMed Atlas E, Bojanowski K, Mehmi I, Lupu R. A deletion mutant of heregulin increases the sensitivity of breast cancer cells to chemotherapy without promoting tumorigenicity. Oncogene. 2003 May 29; 22(22):3441-51. View PubMed Tsai MS, Shamon-Taylor LA, Mehmi I, Tang CK, Lupu R. Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer. Oncogene. 2003 Feb 6; 22(5):761-8. View PubMed Atlas E, Cardillo M, Mehmi I, Zahedkargaran H, Tang C, Lupu R. Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo. Mol Cancer Res. 2003 Jan; 1(3):165-75. View PubMed Tsai MS, Bogart DF, Castaneda JM, Li P, Lupu R. Cyr61 promotes breast tumorigenesis and cancer progression. Oncogene. 2002 Nov 21; 21(53):8178-85. View PubMed Puricelli L, Proietti CJ, Labriola L, Salatino M, Balana ME, Aguirre Ghiso J, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. Int J Cancer. 2002 Aug 20; 100(6):642-53. View PubMed Tsai MS, Bogart DF, Li P, Mehmi I, Lupu R. Expression and regulation of Cyr61 in human breast cancer cell lines. Oncogene. 2002 Jan 31; 21(6):964-73. View PubMed Guerra-Vladusic FK, Vladusic EA, Tsai MS, Lupu R. Signaling molecules implicated in heregulin induction of growth arrest and apoptosis. Oncol Rep. 2001 Nov-Dec; 8(6):1203-14. View PubMed Colomer R, Shamon LA, Tsai MS, Lupu R. Herceptin: from the bench to the clinic. Cancer Invest. 2001; 19(1):49-56. View PubMed Lim SJ, Lopez-Berestein G, Hung MC, Lupu R, Tari AM. Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells. Oncogene. 2000 Dec 14; 19(54):6271-6. View PubMed Tsai MS, Hornby AE, Lakins J, Lupu R. Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies. Cancer Res. 2000 Oct 15; 60(20):5603-7. View PubMed Hijazi MM, Thompson EW, Tang C, Coopman P, Torri JA, Yang D, Mueller SC, Lupu R. Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines. Int J Oncol. 2000 Oct; 17(4):629-41. View PubMed Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lakins J, Lupu R. Expression and regulation of estrogen receptor beta in human breast tumors and cell lines. Oncol Rep. 2000 Jan-Feb; 7(1):157-67. View PubMed Liu WM, Guerra-Vladusic FK, Kurakata S, Lupu R, Kohwi-Shigematsu T. HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype. Cancer Res. 1999 Nov 15; 59(22):5695-703. View PubMed Balana ME, Lupu R, Labriola L, Charreau EH, Elizalde PV. Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas. Oncogene. 1999 Nov 4; 18(46):6370-9. View PubMed Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3. Int J Oncol. 1999 Nov; 15(5):883-92. View PubMed Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proc Natl Acad Sci U S A. 1998 Dec 8; 95(25):14821-6. View PubMed Harris LN, Yang L, Tang C, Yang D, Lupu R. Induction of sensitivity to doxorubicin and etoposide by transfection of MCF-7 breast cancer cells with heregulin beta-2. Clin Cancer Res. 1998 Apr; 4(4):1005-12. View PubMed Vladusic EA, Hornby AE, Guerra-Vladusic FK, Lupu R. Expression of estrogen receptor beta messenger RNA variant in breast cancer. Cancer Res. 1998 Jan 15; 58(2):210-4. View PubMed Hartmann F, Horak EM, Cho C, Lupu R, Bolen JB, Stetler-Stevenson MA, Pfreundschuh M, Waldmann TA, Horak ID. Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines. Int J Cancer. 1997 Jan 17; 70(2):221-9. View PubMed Saceda M, Grunt TW, Colomer R, Lippman ME, Lupu R, Martin MB. Regulation of estrogen receptor concentration and activity by an erbB/HER ligand in breast carcinoma cell lines. Endocrinology. 1996 Oct; 137(10):4322-30. View PubMed Cardillo M, Yankelevich B, Mazumder A, Lupu R. Heregulin induces increase in sensitivity of an erbB-2-overexpressing breast cancer cell type to lysis by lymphokine-activated killer cells. Cancer Immunol Immunother. 1996 Sep; 43(1):19-25. View PubMed Tang CK, Perez C, Grunt T, Waibel C, Cho C, Lupu R. Involvement of heregulin-beta2 in the acquisition of the hormone-independent phenotype of breast cancer cells. Cancer Res. 1996 Jul 15; 56(14):3350-8. View PubMed Sepp-Lorenzino L, Eberhard I, Ma Z, Cho C, Serve H, Liu F, Rosen N, Lupu R. Signal transduction pathways induced by heregulin in MDA-MB-453 breast cancer cells. Oncogene. 1996 Apr 18; 12(8):1679-87. View PubMed Lupu R, Cardillo M, Cho C, Harris L, Hijazi M, Perez C, Rosenberg K, Yang D, Tang C. The significance of heregulin in breast cancer tumor progression and drug resistance. Breast Cancer Res Treat. 1996; 38(1):57-66. View PubMed Grunt TW, Saceda M, Martin MB, Lupu R, Dittrich E, Krupitza G, Harant H, Huber H, Dittrich C. Bidirectional interactions between the estrogen receptor and the cerbB-2 signaling pathways: heregulin inhibits estrogenic effects in breast cancer cells. Int J Cancer. 1995 Nov 15; 63(4):560-7. View PubMed Lupu R, Cardillo M, Harris L, Hijazi M, Rosenberg K. Interaction between erbB-receptors and heregulin in breast cancer tumor progression and drug resistance. Semin Cancer Biol. 1995 Jun; 6(3):135-45. View PubMed Avila MA, Velasco JA, Cho C, Lupu R, Wen D, Notario V. Hyperactive autocrine loop mediated by a NDF-related factor in neoplastic hamster embryo fibroblasts expressing an activated cph oncogene. Oncogene. 1995 Mar 2; 10(5):963-71. View PubMed Elizalde PV, Guerra FK, Gravano M, Lanari C, Lippman ME, Charreau EH, Lupu R. Correlation of TGF-beta 1 expression with medroxyprogesterone acetate responsiveness in mouse mammary adenocarcinomas. Cancer Invest. 1995; 13(2):173-80. View PubMed Colomer R, Lupu R, Bacus SS, Gelmann EP. erbB-2 antisense oligonucleotides inhibit the proliferation of breast carcinoma cells with erbB-2 oncogene amplification. Br J Cancer. 1994 Nov; 70(5):819-25. View PubMed Staebler A, Sommers C, Mueller SC, Byers S, Thompson EW, Lupu R. Modulation of breast cancer progression and differentiation by the gp30/heregulin [correction of neregulin]. Breast Cancer Res Treat. 1994; 31(2-3):175-82. View PubMed Bacus SS, Gudkov AV, Zelnick CR, Chin D, Stern R, Stancovski I, Peles E, Ben-Baruch N, Farbstein H, Lupu R, et al. Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors. Cancer Res. 1993 Nov 1; 53(21):5251-61. View PubMed Noguchi M, Murakami M, Bennett W, Lupu R, Hui F Jr, Harris CC, Gerwin BI. Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cells. Cancer Res. 1993 May 1; 53(9):2035-43. View PubMed Celano P, Berchtold CM, Mabry M, Carroll M, Sidransky D, Casero RA Jr, Lupu R. Induction of markers of normal differentiation in human colon carcinoma cells by the v-rasH oncogene. Cell Growth Differ. 1993 Apr; 4(4):341-7. View PubMed Xu F, Lupu R, Rodriguez GC, Whitaker RS, Boente MP, Berchuck A, Yu Y, DeSombre KA, Boyer CM, Bast RC Jr. Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185. Int J Cancer. 1993 Feb 1; 53(3):401-8. View PubMed Lupu R, Lippman ME. William L. McGuire Memorial Symposium. The role of erbB2 signal transduction pathways in human breast cancer. Breast Cancer Res Treat. 1993; 27(1-2):83-93. View PubMed Lupu R, Dickson RB, Lippman ME. The role of erbB-2 and its ligands in growth control of malignant breast epithelium. J Steroid Biochem Mol Biol. 1992 Sep; 43(1-3):229-36. View PubMed Lupu R, Wellstein A, Sheridan J, Ennis BW, Zugmaier G, Katz D, Lippman ME, Dickson RB. Purification and characterization of a novel growth factor from human breast cancer cells. Biochemistry. 1992 Aug 18; 31(32):7330-40. View PubMed Bacus SS, Huberman E, Chin D, Kiguchi K, Simpson S, Lippman M, Lupu R. A ligand for the erbB-2 oncogene product (gp30) induces differentiation of human breast cancer cells. Cell Growth Differ. 1992 Jul; 3(7):401-11. View PubMed Lupu R, Colomer R, Kannan B, Lippman ME. Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2287-91. View PubMed Bano M, Lupu R, Kidwell WR, Lippman ME, Dickson RB. Production and characterization of mammary-derived growth factor 1 in mammary epithelial cell lines. Biochemistry. 1992 Jan 21; 31(2):610-6. View PubMed Zugmaier G, Paik S, Wilding G, Knabbe C, Bano M, Lupu R, Deschauer B, Simpson S, Dickson RB, Lippman M. Transforming growth factor beta 1 induces cachexia and systemic fibrosis without an antitumor effect in nude mice. Cancer Res. 1991 Jul 1; 51(13):3590-4. View PubMed Lupu R, Dickson RB, Lippman ME. The role of erbB-2 and its ligands in growth control of malignant breast epithelium. Princess Takamatsu Symp. 1991; 22:49-60. View PubMed Lupu R, Colomer R, Zugmaier G, Sarup J, Shepard M, Slamon D, Lippman ME. Direct interaction of a ligand for the erbB2 oncogene product with the EGF receptor and p185erbB2. Science. 1990 Sep 28; 249(4976):1552-5. View PubMed Falco JP, Baylin SB, Lupu R, Borges M, Nelkin BD, Jasti RK, Davidson NE, Mabry M. v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell line. J Clin Invest. 1990 Jun; 85(6):1740-5. View PubMed Wellstein A, Lupu R, Zugmaier G, Flamm SL, Cheville AL, Delli Bovi P, Basilico C, Lippman ME, Kern FG. Autocrine growth stimulation by secreted Kaposi fibroblast growth factor but not by endogenous basic fibroblast growth factor. Cell Growth Differ. 1990 Feb; 1: (2)63-71. View PubMed Yee D, Favoni RE, Lupu R, Cullen KJ, Lebovic GS, Huff KK, Lee PD, Lee YL, Powell DR, Dickson RB, et al. The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells. Biochem Biophys Res Commun. 1989 Jan 16; 158(1):38-44. View PubMed Smorodinsky NI, Argov S, Ghendles Y, Bakimer R, Krup M, Lupu R, Keydar I, Shoenfeld Y. Human monoclonal antibodies derived from pleural effusion lymphocytes of a patient with breast carcinoma react with human breast cancer-associated antigens and mouse mammary tumor virus polypeptides. Exp Cell Biol. 1987; 55(5):237-49. View PubMed PST-20304983 Home Publications