Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Study Of Zanzalintinib In Combination With Immuno-Oncology Or Other Agents In Participants With Solid Tumors

   Jacksonville, Fla., Rochester, Minn., Scottsdale/Phoenix, Ariz.

   This is a multicenter Phase 1b, open label, dose-escalation and cohort-expansion study, evaluating the safety, tolerability, pharmacokinetics (PK), preliminary antitumor activity, and effect of biomarkers of zanzalintinib administered alone, and in combination with nivolumab (doublet), nivolumab + ipilimumab (triplet) and nivolumab + relatlimab (triplet) and in combination with docetaxel and prednisone in participants with advanced solid tumors. In addition, the study will evaluate the effect of multiple dose administration of zanzalintinib on the single-dose pharmacokinetics of sensitive CYP3A4, CYP2C9, CYP2C19, or CYP1A2 substrates in participants with advanced solid tumors.
   
   In the Expansion Stage, the safety and efficacy of zanzalintinib as monotherapy and in combination therapy will be further evaluated in tumor-specific Expansion Cohorts.

2. A Study to Evaluate Preiser's Disease and Its Complications

   Rochester, Minn.

   The purpose of this study is to describe the outcome and complications in surgical management of Preiser',s disease in the past 30 years in the Mayo Clinic.

3. Sugar Hyperabsorption Impact on Post-Bariatric Surgery Weight Loss Outcomes in African American Patients

   Jacksonville, Fla.

   The purpose of this study is to investigate glucose and fructose absorption in enteroids from obese African American subjects before and 1-year post-bariatric surgery compared to age and sex-matched enteroids from obese Caucasian and Hispanic subjects (controls). Also, to profile the expression of glucose and fructose transporters and gluconeogenic enzymes in intestinal tissue from obese African American subjects and compare it to obese Caucasian and Hispanic subjects pre- and post-bariatric surgery.

4. A Study to Evaluate Same Day Discharge Post-mastectomy with/without Alloplastic Breast Reconstruction

   Rochester, Minn.

   In the light of the pandemic, institutions have had to take greater precautions and instigate procedures to aim to improve safety and reduce risk for patients undergoing surgery. One intiative was designed to implement a same day discharge for patients undergoing mastectomy with or without alloplastic reconstruction. This study aims to evaluate the outcomes and patient satisfaction with same day mastectomy with or without alloplastic reconstruction following COVID-19 and compare satisfaction and outcomes (e.g complications) with patients pre-COVID 19. This is part of a quality improvement project. 

5. A Study of Blood Clotting Response in Patients with a Traumatic Injury

   Rochester, Minn.

   The purpose of this study is to look at the blood’s clotting response in people who have suffered a traumatic injury and compare it with non-injured people.

6. Clinical Outcomes of Patients Treated With Open Surgical Repair for Complex Aortic Aneurysms

   Rochester, Minn.

   This is a prospective, non-randomized, single center, data collection study of patients treated with open surgical repair (OR) for complex aortic aneurysms (CAAs).

7. Defining The Immunologic Profile Of Sentinel Lymph Nodes And Identifying The Mechanisms Responsible For Immunosuppression

   Jacksonville, Fla., Rochester, Minn.

   The purpose of this study is to look at the effects cancer and melanoma have on the immune cells found in lymph nodes.