Clinical Studies

Below are current clinical trials.

127 studies in Pediatrics (open studies only).

Filter this list of studies by location, status and more.

  1. A Study to Evaluate a Primary Care-Based Intervention for Adolescent Restrictive Eating Disorders

    1. Rochester, Minn.

    The purpose of this study is to assess the feasibility, acceptability, usability, and preliminary outcomes of a treatment protocol (FBT-PC) for PCP management of adolescent restrictive eating disorders.

  2. Study of Clinical Variables and Serum Anti-RSV Titer Before and After Administration of Polyclonal Immunoglobulin with High-Titer RSV Immunoglobulin

    1. Rochester, Minn.

    The purpose of this study is to assess the effect of administration of polyclonal immunoglobulin with high-titer respiratory syncytial virus (RSV) immunoglobulin (RI-002, ADMA Biologics) in relation to clinical variables,
    serum anti-RSV titer and RSV type and palivizumab sensitivity.

  3. A Study to Investigate the Effectiveness and Safety of Pf-04965842 in Subjects Aged 12 Years and Over, With Moderate to Severe Atopic Dermatitis with the Option of Rescue Treatment in Flaring Subjects

    1. Rochester, Minn.

    The purpose of this study is to investigate PF-04965842 in patients aged 12 years and over with a minimum body weight of 40 kg who have moderate to severe atopic dermatitis.

  4. A Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

    1. Rochester, Minn.

    The purpose of this study is to evaluate children ≥ 1 year of age and adults with neurofibromatosis type 1 (NF1) and plexiform neurofibromas treated with the MEK inhibitor, binimetinib. The primary objective is to determine if there is an adequate level of disease responsiveness to binimetinib in children and adults with NF1 and inoperable plexiform neurofibromas. The objective response to binimetinib is defined as ≥ 20% decrease in tumor volume reduction by 12 courses.

  5. A Study of to Determine the Effectiveness and Safety of Ligelizumab in the Treatment of Chronic Spontaneous Urticaria (CSU)(Hives) in Adolescents and Adults Inadequately Controlled With H1-antihistamines.

    1. Rochester, Minn.

    The purpose of this study is to establish effectivess and safety of ligelizumab in adolescent and adult subjects with Chronic Spontaneous Urticaria (CSU), or Hives, who remain symptomatic despite standard of care treatment by demonstrating better efficacy over omalizumab. The study population will consist of approximately 1050 male and female subjects aged ≥ 12 years who have been diagnosed with CSU and who remain symptomatic despite the use of H1-antihistamines. Of these, approximately 1000 adults and 50 adolescents are planned for inclusion in the study. This is a multi-center, randomized, double-blind, active- and placebo-controlled, parallel-group study. There is a screening period of up to 28 days, a 52 week double-blind treatment period, and a 12 week post-treatment follow-up period.

  6. A Study to Assess the Effect of Exercise on Patching Treatment for Children with Amblyopia

    1. Rochester, Minn.

    The purpose of this study is to establish whether moderate physical exercise enhances treatment benefit when patching 2 hours a day for residual amblyopia in children.

  7. A Study to Assess the Effectiveness and Safety of Golimumab in Pediatric Participants With Moderately-to-Severely Active Ulcerative Colitis

    1. Rochester, Minn.

    The purpose of this study is to evaluate effectiveness of golimumab in inducing clinical remission as assessed by the Mayo score, in pediatric participants with moderately to severely active ulcerative colitis (UC). In addition, the safety profile of golimumab, in pediatric participants with moderately to severely active UC will be assessed.

  8. Intensive Parent-child Interaction Therapy (I-PCIT): Feasibility and Effectiveness Study.

    1. La Crosse, Wis.
    2. Rochester, Minn.

    The purpose of this study is to evaluate the feasibility of implementing I-PCIT in a community clinic, measured by treatment attendance and caregiver’s satisfaction compared to the current gold-standard of PCIT-au.

  9. A Safety Study of Autologous Umbilical Cord Blood Cells for Treatment of Hypoplastic Left Heart Syndrome

    1. Rochester, Minn.

    The purpose of this study is to determine the safety and feasibility of injections of autologous umbilical cord blood (UCB) cells into the right ventricle of Hypoplastic Left Heart Syndrome (HLHS) children undergoing a scheduled Glenn surgical procedure. The investigators are doing this research study to find out if autologous stem cells from the individual's own umbilical cord blood can be used to strengthen the muscle of the right side of their heart. This will help determine the safety and feasibility of using cell-based regenerative therapy as an additional treatment for the management of HLHS.

  10. A Study to Establish a Registry for Niemann-Pick Disease Type A, B, and C

    1. Rochester, Minn.

    The purpose of this study is to establish the natural history of the 3 diseases - Niemann-Pick Type A, B, and C (their characteristics, management and outcomes).

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