医疗专业人员

下面列出了当前开展的临床试验。

根据地点、状态和其他条件对此研究列表进行过滤。

1. Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

   Rochester, Minn.

   The purpose of this study is to provide expanded access of patisiran to patients with hereditary transthyretin-mediated amyloidosis (hATTR).

2. the Mayo Cardiac Sarcoid Registry

   Rochester, Minn., Jacksonville, Fla.

   Aims, purpose, or objectives:

   1. Develop a retrospective registry of patients with cardiac sarcoidosis
   2. Develop a prospective registry of patients with cardiac sarcoidosis
   3. Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry
   4. Determine risk factors for sarcoid involvement of the heart
   5. Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis
   6. Understand the complications of untreated and treated cardiac sarcoidosis

    

3. A Study to Identify the Genetic Defect(s) in Individuals with Arrhythmogenic Bi-Leaflet Mitral Prolapse (aBiMVP)

   Rochester, Minn.

   The purpose of this study is to elucidate the genetic basis of aBiMVP in hopes of determining novel mechanisms that underlie aBiMVP pathogenesis.

4. A Study to Compare the Effectiveness of Different High-intensity Interval Training Programs in Cardiac Rehabilitation

   Rochester, Minn.

   The main purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen. The two approaches of the same total exercise durston will include: 1) HIIT with progressively increased interval durations (PRO-HIIT) versus 2) HIIT with constant shorter interval durations (CON-HIIT). The study hypothesis is that the progressively increased interval duration at high-intensity (PRO-HIIT) will result in a greater increases in fitness, heart function, and the ability of the body's muscles to receive oxygen in patients enrolled in cardiac rehabilitation. 

5. A Study to Evaluate Aortic Dilatation in Patients with Conotruncal Abnormalities

   Rochester, Minn.

   The purpose of this study is to assess operative and postoperative outcomes after aortic valve surgery, evaluate for changes in ascending aorta diameter by comparing pre-operative CT imaging to measurements on follow-up imaging, and examine late outcomes and functional status during the follow-up period with specific focus on mortality, need for re-operation and incidence of aortic dissection.

6. Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial

   Rochester, Minn.

   The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke.

7. A Study of Sexual Dysfunction in Patients with Hypertrophic Obstructive Cardiomyopathy Undergoing Septal Myectomy

   Rochester, Minn.

   The purpose of this study is to determine how many patients suffer from sexual function problems and ascertain if they are improved or modified by cardiac surgical intervention.

8. Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload

   Rochester, Minn.

   The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload.

9. Evaluation of the GORE® EXCLUDER® Thoracoabdominal Branch Endoprosthesis in the Treatment of Thoracoabdominal and Pararenal Aortic Aneurysms

   Rochester, Minn.

   Prospective, non-randomized, , multicenter study with two independent arms: * Primary Study Arm - TAAA and Pararenal aneurysms requiring only TAMBE System. Hypothesis-driven analysis. * Up to 65 additional subjects may be implanted in Continued Access Phase under the Primary Study Arm only * Secondary Study Arm - TAAA requiring TAMBE System and CTAG Device(s). Non hypothesis-driven analysis. Minimum: 122 implanted subjects. Maximum: 202 implanted subjects with up to 65 additional subjects implanted in Continued Access (Primary Study arm)

10. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

    Scottsdale/Phoenix, Ariz.

    Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.