Mild forms of von Willebrand disease can be difficult to diagnose because bleeding is common, and, for most people, doesn't indicate a disease. However, if your doctor suspects you have a bleeding disorder, he or she might refer you to a blood disorders specialist (hematologist).

To evaluate you for von Willebrand disease, your doctor will likely ask you detailed questions about your medical history and check for bruises or other signs of recent bleeding.

Your doctor will also likely recommend the following blood tests:

  • Von Willebrand factor antigen. This determines the level of von Willebrand factor in your blood by measuring a particular protein.
  • Von Willebrand factor activity. There are a variety of tests to measure how well the von Willebrand factor works in your clotting process.
  • Factor VIII clotting activity. This shows whether you have abnormally low levels and activity of factor VIII.
  • Von Willebrand factor multimers. This evaluates the structure of von Willebrand factor in your blood, its protein complexes and how its molecules break down. This information helps identify the type of von Willebrand disease you have.

The results of these tests can fluctuate in the same person over time due to factors such as stress, exercise, infection, pregnancy and medications. So you might need to repeat some tests.

If you have von Willebrand disease, your doctor might suggest that family members undergo tests to determine if this condition runs in your family.


Even though von Willebrand disease has no cure, treatment can help prevent or stop bleeding episodes. Your treatment depends on:

  • The type and severity of your condition
  • How you've responded to previous therapy
  • Your other medications and conditions

Your doctor might suggest one or more of the following treatments to increase your von Willebrand factor, strengthen blood clots or control heavy menstrual bleeding:

  • Desmopressin. This medication is available as an injection (DDAVP). It's a synthetic hormone that controls bleeding by stimulating your body to release more of the von Willebrand factor stored in the lining of your blood vessels.

    Many doctors consider desmopressin (DDAVP) the first treatment for managing von Willebrand disease. It can be used before minor surgical procedures to help control bleeding. You might be given a trial of desmopressin to make sure it's effective for you.

  • Replacement therapies. These include infusions of concentrated blood-clotting factors containing von Willebrand factor and factor VIII. Your doctor might recommend them if DDAVP isn't an option for you or has been ineffective.

    Another replacement therapy approved by the Food and Drug Administration for treating adults 18 and older is a genetically engineered (recombinant) von Willebrand factor product. Because recombinant factor is made without plasma, it can reduce the risk of a viral infection or allergic reaction.

  • Oral contraceptives. In addition to preventing pregnancy, these drugs can help control heavy bleeding during menstrual periods. The estrogen hormones in birth control pills can boost von Willebrand factor and factor VIII activity.
  • Clot-stabilizing medications. These anti-fibrinolytic medications — such as aminocaproic acid (Amicar) and tranexamic acid (Cyklokapron, Lysteda) — can help stop bleeding by slowing the breakdown of blood clots. Doctors often prescribe these drugs before or after a surgical procedure or tooth extraction.
  • Drugs applied to cuts. A fibrin sealant (Tisseel) placed on a cut helps curtail bleeding. This is applied like glue using a syringe. There are also over-the-counter products to stop nosebleeds.

If your condition is mild, your doctor might recommend treatment only when you're having surgery or dental work or when you've had a trauma, such as a car accident.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Self care

These self-care tips can help you manage your condition:

  • Switch pain relievers. To help prevent bleeding episodes, talk with your doctor before taking blood-thinning medications — such as aspirin, ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve). Your doctor might instead recommend pain and fever relievers such as acetaminophen (Tylenol, others).
  • Tell your doctors and dentist. Let your doctors or dentist know that you have von Willebrand disease before you have surgery, start a new medication or give birth. Also mention whether anyone in your family has a history of excessive bleeding.
  • Consider wearing a medical ID bracelet. Make sure it notes that you have von Willebrand disease, which will be helpful to medical personnel if you're in an accident or taken to an emergency room. Also carry a medical alert card in your wallet.
  • Be active and safe. Exercise is part of attaining or maintaining a healthy weight. Avoid activities that could cause bruising, such as football, wrestling and hockey.

Preparing for your appointment

You'll likely see your family doctor if you think you have a bleeding problem. You then might be referred to a doctor who specializes in the diagnosis and treatment of bleeding disorders (hematologist).

Here's some information to help you get ready for your appointment.

What you can do

Ask about pre-appointment restrictions when you make the appointment. You might need to follow dietary restrictions or fast for 8-10 hours if blood tests are scheduled.

Make a list of:

  • Signs or symptoms that involve bleeding, including how often, how severe and for how long. Include unusual bruising. Your doctor will want to know if you have a history of nosebleeds or easy bruising since childhood. If you menstruate, are your periods extended and heavy?
  • Key personal information, including major stresses or recent changes — both positive and negative.
  • Key medical information, including other medical problems and close relatives who bleed easily. Also list medications, vitamins or other supplements you take, including doses.
  • Questions to ask your doctor.

Take a family member or friend along, if possible, to help you remember the information you'll be given.

For von Willebrand disease, questions to ask your doctor include:

  • What's the most likely reason for my symptoms?
  • What treatment do you recommend, and how will you monitor whether it's working?
  • What are the possible side effects of the medications you're prescribing?
  • Does this condition increase my risk of other medical problems?
  • What will I need to do before having surgery or dental procedures?
  • Does this condition increase my risk of health problems during pregnancy and childbirth? Are treatment options available to reduce that risk?
  • Do I need to avoid certain physical activities or types of exercise?
  • I have other health conditions. How can I best manage them together?

What to expect from your doctor

Your doctor might ask:

  • Have you had bleeding from a small wound that lasted more than 15 minutes or recurred during the week following the wound?
  • Have you had a nosebleed that lasted more than 10 minutes or needed medical attention?
  • Have you had unexpected bruising? Have you ever felt a lump under the bruise?
  • If you menstruate, how many days do your periods last? How often do you change your tampon or sanitary pad during a period? Have you seen blood clots in your menstrual flow?
  • Have you had blood in your stool that wasn't explained by a known medical problem, such as a stomach ulcer or colon polyp?
  • Have you ever needed medical attention for bleeding during or after surgery, dental procedures, childbirth or injury?
  • Have you had anemia or needed a blood transfusion?

What you can do in the meantime

While you wait for your appointment, avoid pain relievers that can increase your risk of bleeding, such as aspirin, ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve). If you need relief for aches and pains, try acetaminophen (Tylenol, others) instead.

Steer clear of contact sports associated with a high risk of bruising or injury, such as football and hockey. If you have medical or dental procedures scheduled, tell your doctor or dentist about your history of heavy bleeding from minor injuries.

If you're having a procedure that's not urgent, reschedule it until after you've been evaluated for a bleeding disorder.

Oct 26, 2021

  1. Von Willebrand disease. Centers for Disease Control and Prevention. https://www.cdc.gov/ncbddd/vwd/facts.html. Accessed Aug. 26, 2021.
  2. AskMayoExpert. Von Willebrand disease. Mayo Clinic; 2021.
  3. Rick ME. Clinical presentation and diagnosis of von Willebrand disease. https://www.uptodate.com/contents/search. Accessed Aug. 26, 2021.
  4. Von Willebrand disease. National Organization for Rare Disorders. https://rarediseases.org/rare-diseases/von-willebrand-disease/. Accessed Aug. 26, 2021.
  5. Rick ME. Von Willebrand disease: Treatment of minor bleeding and routine care. https://www.uptodate.com/contents/search. Accessed Aug. 26, 2021.
  6. Rick ME. Von Willebrand disease: Treatment of major bleeding and major surgery. https://www.uptodate.com/contents/search. Accessed Aug. 26, 2021.
  7. Connell NT, et al. ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease. Blood Advances. 2021; doi:10.1182/bloodadvances.2020003264.


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