Pseudogout (SOO-doe-gout) is a form of arthritis characterized by sudden, painful swelling in one or more of your joints. These episodes can last for days or weeks. The most commonly affected joint is the knee.
Also called calcium pyrophosphate deposition disease or CPPD, the common term "pseudogout" was coined for the condition's similarity to gout. Crystal deposits within a joint cause both conditions, although the type of crystal differs for each condition.
It isn't clear why crystals form in your joints and cause pseudogout, but the risk increases with age. Treatments can help relieve pain and reduce inflammation.
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Pseudogout most commonly affects the knees. Less often, wrists and ankles are involved. In many cases, there are no symptoms. However, during a pseudogout attack, the affected joints are usually:
- Severely painful
When to see a doctor
Make an appointment with your doctor if you have sudden, intense joint pain and swelling.
Pseudogout has been linked to the presence of calcium pyrophosphate dihydrate crystals within the affected joint. These crystals become more numerous as people age, appearing in nearly half the population older than age 85. But most people who have these crystal deposits never develop pseudogout. It's not clear why some people have symptoms and others don't.
Factors that can increase your risk of pseudogout include:
- Older age. The risk of developing pseudogout increases with age.
- Joint trauma. Trauma to a joint, such as a serious injury or surgery, increases your risk of pseudogout in that joint.
- Genetic disorder. In some families, a predisposition for developing pseudogout is hereditary. These people tend to develop pseudogout at younger ages.
- Mineral imbalances. The risk of pseudogout is higher for people who have excessive calcium or iron in their blood or too little magnesium.
- Other medical conditions. Pseudogout has also been linked to an underactive thyroid gland or an overactive parathyroid gland.
The crystal deposits associated with pseudogout can also cause joint damage, which can mimic the signs and symptoms of osteoarthritis or rheumatoid arthritis.
July 16, 2020
- Calcium pyrophasphate deposition (CPPD). American College of Rheumatology. https://www.rheumatology.org/Practice/Clinical/Patients/Diseases_And_Conditions/Calcium_Pyrophosphate_Deposition_%28CPPD%29_%28formerly_called_Pseudogout%29/. Accessed May 14, 2015.
- Becker MA, et al. Pathogenesis and etiology of calcium pyrophosphate crystal deposition disease. http://www.uptodate.com/home. Accessed May 14, 2015.
- Becker MA, et al. Treatment of calcium pyrophosphate crystal deposition disease. http://www.uptodate.com/home. Accessed May 14, 2015.
- Becker MA, et al. Clinical manifestations and diagnosis of calcium pyrophosphate crystal deposition disease. http://www.uptodate.com/home. Accessed May 14, 2015.
- Calcium pyrophasphate deposition (CPPD) disease. Arthritis Foundation. http://www.arthritis.org/about-arthritis/types/calcium-pyrophosphate-deposition-disease-cppd/. Accessed May 14, 2015.
- Terkeltaub, R. New insights into CPPD. The Rheumatologist. 2013. http://www.the-rheumatologist.org/details/article/5314721/New_Insights_into_CPPD.html. Accessed May 14, 2015.
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