Overview

Paget's (PAJ-its) disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, bones can become fragile and misshapen. The pelvis, skull, spine and legs are most commonly affected.

The risk of Paget's disease of bone increases with age and if family members have the disorder. However, for reasons unknown to doctors, the disease has become less common over the past several years and is less severe when it does develop. Complications can include broken bones, hearing loss and pinched nerves in your spine.

Bisphosphonates — the medications used to strengthen bones weakened by osteoporosis — are the mainstay of treatment. Surgery may be necessary if complications occur.

Symptoms

Most people who have Paget's disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain.

Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's less organized and weaker than normal bone, which can lead to bone pain, deformities and fractures.

The disease might affect only one or two areas of your body or might be widespread. Your signs and symptoms, if any, will depend on the affected part of your body.

  • Pelvis. Paget's disease of bone in the pelvis can cause hip pain.
  • Skull. An overgrowth of bone in the skull can cause hearing loss or headaches.
  • Spine. If your spine is affected, nerve roots can become compressed. This can cause pain, tingling and numbness in an arm or leg.
  • Leg. As the bones weaken, they may bend — causing you to become bowlegged. Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip.

When to see a doctor

Talk to your doctor if you have:

  • Pain in your bones and joints
  • Tingling and weakness in an extremity
  • Bone deformities
  • Unexplained hearing loss, especially if it's only on one side

Causes

The cause of Paget's disease of bone is unknown. Scientists suspect a combination of environmental and genetic factors contribute to the disease. Several genes appear to be linked to getting the disease.

Some scientists believe Paget's disease of bone is related to a viral infection in your bone cells, but this theory is controversial.

Risk factors

Factors that can increase your risk of Paget's disease of bone include:

  • Age. People older than 50 are most likely to develop the disease.
  • Sex. Men are more commonly affected than are women.
  • National origin. Paget's disease of bone is more common in England, Scotland, central Europe and Greece — as well as countries settled by European immigrants. It's uncommon in Scandinavia and Asia.
  • Family history. If you have a relative who has Paget's disease of bone, you're more likely to develop the condition.

Complications

In most cases, Paget's disease of bone progresses slowly. The disease can be managed effectively in nearly all people. Possible complications include:

  • Fractures and deformities. Affected bones break more easily, and extra blood vessels in these deformed bones cause them to bleed more during repair surgeries. Leg bones can bow, which can affect your ability to walk.
  • Osteoarthritis. Misshapen bones can increase the amount of stress on nearby joints, which can cause osteoarthritis.
  • Neurological problems. When Paget's disease of bone occurs in an area where nerves pass through the bone, such as the spine and skull, the overgrowth of bone can compress and damage the nerve, causing pain, weakness or tingling in an arm or leg or hearing loss.
  • Heart failure. In severe cases, your heart may have to work harder to pump blood to the affected areas of your body. Sometimes, this increased workload can lead to heart failure.
  • Bone cancer. Bone cancer occurs in up to 1% of people with Paget's disease of bone.

Feb. 03, 2021
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