Sept. 25, 2015
Below are current clinical trials.53 studies in Lung cancer
(open studies only).
Filter this list of studies by location, status and more.
The purpose of this study is to characterize the safety and tolerability of combined treatment with mogamulizumab and nivolumab, and also determine the maximum tolerated dose and the recommended fixed dose for the treatment of patients who have locally advanced or metastatic solid tumors.
This study will evaluate the impact of a proactive, EHR-supported enrollment strategy that links LDCT-eligible smokers with an evidence-based intervention comprised of a web-based program and integrated text messaging. The goal is to provide actionable findings about how to most effectively and cost efficiently promote abstinence in LDCT clinics.
The purpose of this study is to assess the possibility, safety, and therapeutic effect of administering a short, quick course of high-dose radiation treatment focused on half of the chest, followed by surgery to remove that portion of the lungs, in patients with malignant pleural mesothelioma.
The purpose of this study is to evaluate the effectiveness and safety of X-396 (ensartinib) versus crizotinib in patients who have ALK-positive non-small cell lung cancer that have received up to 1 prior chemotherapy regimen and no prior ALK inhibitor.
La Crosse, Wis., Mankato, Minn., Rochester, Minn.
This randomized phase III trial studies how well smoking cessation intervention works in reducing surgical complications in patients with newly diagnosed lung cancer who smoke cigarettes. This study will use two smoking cessation interventions: Varenicline (a drug that reduces the craving and withdrawal symptoms that occur with abstinence from nicotine) with behavioral interventions (consisting of a brief clinician-delivered intervention and tobacco quitline [tobacco cessation service available through a toll-free telephone number] follow-up) with placebo (a pill with no active medication) along with the same behavioral interventions. It is not yet known whether smoking cessation intervention prior to surgery is effective in reducing surgical complications for these patients.
The study will utilize both retrospective and prospective data collection from patients that already had a bronchoscopy and lung resection or will have a bronchoscopy and lung resection for squamous cell carcinoma. The investigators plan to prospectively collect 5 bronchoscopic biopsies, 3ml blood and one tumor and adjacent normal samples from 200 qualified patients who meet the study criteria.
The purpose of this study is to better understand how the immune system, the body's natural defense against infection and harmful cells, is affected by the presence of lung cancer and the treatment of lung cancer.
Scottsdale/Phoenix, Ariz., Rochester, Minn.
This study is being done to study which dose of proton beam therapy (PBT) for unresectable stage 2/3 Non-Small Cell Lung Cancer.
The purpose of this study is to follow patients with malignant mesothelioma of the lung after they have had combined chemotherapy, surgery, and intensity modified radiation therapy and determine response rates and overall survival.
The purpose of this study is to compare whether surgical staging is more accurate than imaging procedures when diagnosing malignant lung mesothelioma.
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- Small cell lung cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Aug. 27, 2015.
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- What you need to know about lung cancer. National Cancer Institute. http://www.cancer.gov/publications/patient-education/wyntk-lung-cancer. Accessed Aug. 27, 2015.
- Lung cancer prevention (PDQ). National Cancer Institute. http://www.cancer.gov/types/lung/patient/lung-prevention-pdq. Accessed Aug. 27, 2015.
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- Detterbeck FC, et al. Diagnosis and management of lung cancer, 3rd ed.: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(suppl):7S.
- AskMayoExpert. Non-small cell lung cancer. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
- AskMayoExpert. Small cell lung cancer. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
- Cook AJ. Decision Support System. Mayo Clinic, Rochester, Minn. March 17, 2015.
- Cairns LM. Managing breathlessness in patients with lung cancer. Nursing Standard. 2012;27:44.
- Taking time: Support for people with cancer. National Cancer Institute. http://www.cancer.gov/publications/patient-education/taking-time. Accessed Aug. 27, 2015.
- Temel JS, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. New England Journal of Medicine. 2010;363:733.