Your thyroid gland is located at the base of your neck, just below the Adam's apple.
Hurthle (HEERT-luh) cell cancer is a rare cancer that affects the thyroid gland.
The thyroid is a butterfly-shaped gland in the base of your neck. It secretes hormones that are essential for regulating your body's metabolism.
Hurthle cell cancer is also called Hurthle cell carcinoma or oxyphilic cell carcinoma. Hurthle cell cancer is one of several types of cancers that affect the thyroid.
Hurthle cell cancer can be more aggressive than other types of thyroid cancer. Surgery to remove the thyroid gland is the most common treatment.
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Hurthle cell cancer doesn't always cause symptoms, and it's sometimes detected during a physical examination or an imaging test done for some other reason.
Signs and symptoms of Hurthle cell cancer may include:
- A lump in your neck, just below your Adam's apple
- Pain in your neck or throat
- Hoarseness or other changes in your voice
- Shortness of breath
- Swallowing difficulty
These signs and symptoms don't necessarily mean you have Hurthle cell cancer. They may be indications of other medical conditions — such as inflammation of the thyroid gland or a noncancerous enlargement of the thyroid (goiter).
When to see a doctor
Make an appointment with your doctor if you have any signs or symptoms that worry you.
It's not clear what causes Hurthle cell cancer.
Doctors know that cancer begins when a cell develops errors in its DNA — the genetic material that contains instructions for biochemical processes in your body. When DNA is altered or damaged, these genes may not function properly, causing cells to grow out of control and eventually form a mass (tumor) of cancerous (malignant) cells.
Factors that increase the risk of developing thyroid cancer include:
- Being female
- Being older
- Having a history of radiation treatments to the head and neck
Possible complications of Hurthle cell cancer include:
- Problems with swallowing and breathing. They can occur if the tumor grows and presses on the food tube (esophagus) and windpipe (trachea).
- Spread of the cancer. Hurthle cell cancer can spread (metastasize) to other tissues and organs, making treatment and recovery more difficult.
Jan. 30, 2020
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- Thyroid carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Jan. 26, 2018.
- Niederhuber JE, et al., eds. Cancer of the endocrine system. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. https://www.clinicalkey.com. Accessed Jan. 30, 2018.
- Haugen BR, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1.
- What you need to know about thyroid cancer. National Cancer Institute. https://www.cancer.gov/publications/patient-education/wyntk-thyroid-cancer. Accessed Jan. 26, 2018.
- Nippoldt TB (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 9, 2018.
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