Hantavirus pulmonary syndrome is a rare infectious disease that begins with flu-like symptoms and progresses rapidly to more severe disease. It can lead to life-threatening lung and heart problems. The disease is also called hantavirus cardiopulmonary syndrome.

Several strains of the hantavirus can cause hantavirus pulmonary syndrome. They are carried by different types of rodents. The most common carrier in North America is the deer mouse. Infection is usually caused by inhaling hantaviruses that have become airborne from rodent urine, droppings or saliva.

Because treatment options are limited, the best protection against hantavirus pulmonary syndrome is to avoid contact with rodents and safely clean up rodent habitats.


The time from infection with the hantavirus to the start of illness is usually about 2 to 3 weeks. Hantavirus pulmonary syndrome advances through two distinct stages. In the first stage, which can last for several days, the most common signs and symptoms are:

  • Fever and chills
  • Muscle aches or pain
  • Headache

Some people also experience:

  • Nausea
  • Stomach pain
  • Vomiting
  • Diarrhea

As the disease progresses, it can lead to damaged lung tissues, fluid build-up in the lungs, and serious problems with lung and heart function. Signs and symptoms may include:

  • Cough
  • Difficulty breathing
  • Low blood pressure
  • Irregular heart rate

When to see a doctor

The signs and symptoms of hantavirus pulmonary syndrome can worsen suddenly and may quickly become life-threatening. If you have flu-like symptoms that progressively worsen over a few days, see your health care provider. Get immediate medical care if you have trouble breathing.


Rodent carriers

Hantavirus pulmonary syndrome is a human disease found only in North and South America. Each strain of the hantavirus has a preferred rodent carrier.

The deer mouse is the most common carrier of the virus in North America and Central America. In the United States, most of the infections occur in the states west of the Mississippi River.

Other carriers in North America include the rice rat and cotton rat in the Southeast and the white-footed mouse in the Northeast. Rodent carriers in South America include the rice rat and the vesper mouse.


The virus is present in the rodent's urine, feces or saliva. You can come in contact with the virus in the following ways:

  • Inhaling viruses — the most likely form of transmission — when they become airborne from disturbed rodent droppings or nesting materials
  • Eating food contaminated with mouse saliva, urine or droppings
  • Touching things contaminated with the virus, such as a nest, and then touching your mouth, eyes or nose
  • Being bitten or scratched by an infected rodent

Person-to-person transmission of the virus has only been recorded with a strain of the virus found in South America called the Andes virus.

Effect of the virus

When hantaviruses reach the lungs, they invade tiny blood vessels called capillaries, eventually causing them to leak. Your lungs fill with fluid (pulmonary edema), resulting in severe dysfunction of the lungs and heart.

Related disease

Another disease caused by different strains of the hantavirus is called hemorrhagic fever with renal syndrome, which causes severe kidney disease. These variants of the virus have other animal carriers in Africa, Asia and Europe.

Risk factors

In the United States, hantavirus pulmonary syndrome is most common in rural areas of the West. However, any exposure to rodent habitats can increase the risk of disease.

Common sites for exposure to rodent nests, urine and droppings include:

  • Farm buildings
  • Infrequently used buildings, such as storage sheds
  • Campers or seasonal cabins
  • Camp sites or hiking shelters
  • Attics or basements
  • Construction sites

Activities that can increase the risk of exposure to the hantavirus include:

  • Opening and cleaning long unused buildings
  • Cleaning up rodent nests or droppings without appropriate precautions
  • Working in a field that increases exposure to rodents, such as construction, utility work, pest control and farming


Hantavirus pulmonary syndrome can quickly become life-threatening. Severe disease can result in failure of the heart to deliver oxygen to the body. Each strain of the virus differs in severity. The death rate due to the strain carried by deer mice ranges from 30% to 50%.


Keeping rodents out of your home and workplace can help reduce your risk of hantavirus infection. Try these tips:

  • Block access. Mice can squeeze through holes as small as 1/4 inch (6 millimeters) wide. Seal holes with wire screening, steel wool, metal flashing or cement.
  • Close the food buffet. Wash dishes promptly, clean counters and floors, and store your food — including pet food — in rodent-proof containers. Use tightfitting lids on garbage cans.
  • Reduce nesting material. Clear brush, grass and junk away from a building's foundation.
  • Set traps. Spring-loaded traps should be set along baseboards. Exercise caution while using poison-bait traps, as the poison also can harm people and pets.
  • Move rodent-friendly yard items. Move woodpiles or compost bins away from the house.
  • Air out unused spaces. Open up and air out cabins, campers or infrequently used buildings before cleaning.

Safe cleanup procedures

Safe cleaning will help prevent the spread of viruses. Follow these steps:

  • Wear a mask and rubber or plastic gloves.
  • Spray the nest, droppings or dead rodent with a household disinfectant, alcohol or bleach and water solution. Let it sit for five minutes.
  • Use paper towels to clean up and dispose of towels in garbage.
  • Mop or sponge the area with a disinfectant.
  • Wash gloved hands and dispose of gloves and mask.
  • Wash your hands thoroughly with soap and water.

Jan 07, 2022

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