Stomach and pyloric valve
Your stomach is a muscular sac about the size of a small melon that expands when you eat or drink. It holds as much as a gallon (3.8 liters) of food or liquid. Once your stomach breaks down the food, strong muscular contractions known as peristaltic waves push the food toward the pyloric valve. This valve leads to the upper portion of your small intestine, a segment known as the duodenum.
Gastroparesis is a condition that affects the normal spontaneous movement of the muscles (motility) in your stomach. Ordinarily, strong muscular contractions propel food through your digestive tract. But if you have gastroparesis, your stomach's motility is slowed down or doesn't work at all, preventing your stomach from emptying properly.
The cause of gastroparesis is usually unknown. Sometimes it's a complication of diabetes, and some people develop gastroparesis after surgery. Certain medications, such as opioid pain relievers, some antidepressants, and high blood pressure and allergy medications, can lead to slow gastric emptying and cause similar symptoms. For people who already have gastroparesis, these medications may make their condition worse.
Gastroparesis can interfere with normal digestion, cause nausea, vomiting and abdominal pain. It can also cause problems with blood sugar levels and nutrition. Although there's no cure for gastroparesis, changes to your diet, along with medication, can offer some relief.
Signs and symptoms of gastroparesis include:
- Abdominal bloating
- Abdominal pain
- A feeling of fullness after eating just a few bites
- Vomiting undigested food eaten a few hours earlier
- Acid reflux
- Changes in blood sugar levels
- Lack of appetite
- Weight loss and malnutrition
Many people with gastroparesis don't have any noticeable signs and symptoms.
When to see a doctor
Make an appointment with your doctor if you have any signs or symptoms that worry you.
From Mayo Clinic to your inbox
Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview.
ErrorEmail field is required
ErrorInclude a valid email address
To provide you with the most relevant and helpful information, and understand which
information is beneficial, we may combine your email and website usage information with
other information we have about you. If you are a Mayo Clinic patient, this could
include protected health information. If we combine this information with your protected
health information, we will treat all of that information as protected health
information and will only use or disclose that information as set forth in our notice of
privacy practices. You may opt-out of email communications at any time by clicking on
the unsubscribe link in the e-mail.
Thank you for subscribing!
You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox.
Sorry something went wrong with your subscription
Please, try again in a couple of minutes
It's not always clear what leads to gastroparesis, but in some cases it can be caused by damage to a nerve that controls the stomach muscles (vagus nerve).
The vagus nerve helps manage the complex processes in your digestive tract, including signaling the muscles in your stomach to contract and push food into the small intestine. A damaged vagus nerve can't send signals normally to your stomach muscles. This may cause food to remain in your stomach longer, rather than move into your small intestine to be digested.
The vagus nerve and its branches can be damaged by diseases, such as diabetes, or by surgery to the stomach or small intestine.
Factors that can increase your risk of gastroparesis:
- Abdominal or esophageal surgery
- Infection, usually from a virus
- Certain medications that slow the rate of stomach emptying, such as narcotic pain medications
- Scleroderma — a connective tissue disease
- Nervous system diseases, such as Parkinson's disease or multiple sclerosis
- Underactive thyroid (hypothyroidism)
Women are more likely to develop gastroparesis than are men.
Gastroparesis can cause several complications, such as:
- Severe dehydration. Ongoing vomiting can cause dehydration.
- Malnutrition. Poor appetite can mean you don't take in enough calories, or you may be unable to absorb enough nutrients due to vomiting.
- Undigested food that hardens and remains in your stomach. Undigested food in your stomach can harden into a solid mass called a bezoar. Bezoars can cause nausea and vomiting and may be life-threatening if they prevent food from passing into your small intestine.
- Unpredictable blood sugar changes. Although gastroparesis doesn't cause diabetes, frequent changes in the rate and amount of food passing into the small bowel can cause erratic changes in blood sugar levels. These variations in blood sugar make diabetes worse. In turn, poor control of blood sugar levels makes gastroparesis worse.
- Decreased quality of life. Symptoms can make it difficult to work and keep up with other responsibilities.