Descripción general

El linfoma cutáneo de células B es un tipo de cáncer poco frecuente que comienza en los glóbulos blancos. Este cáncer ataca la piel. El linfoma cutáneo de linfocitos B afecta un tipo de glóbulos blancos que luchan contra los gérmenes, llamados linfocitos B. Estas células también se conocen como linfocitos B.

Los tipos de linfoma cutáneo de linfocitos B incluyen los siguientes:

  • Linfoma cutáneo primario del centro folicular
  • Linfoma cutáneo primario de linfocitos B de la zona marginal
  • Linfoma cutáneo primario de linfocitos B grandes difusos, el tipo que se produce en la pierna
  • Linfoma intravascular difuso de linfocitos B grandes

Los síntomas del linfoma cutáneo de linfocitos B incluyen un bulto o grupo de bultos en la piel. En ocasiones, este cáncer causa parches duros en la piel.

El linfoma cutáneo de linfocitos B es un tipo de linfoma no Hodgkin. Otro tipo de linfoma no Hodgkin que afecta la piel se llama linfoma cutáneo de linfocitos T. El linfoma cutáneo de linfocitos T es más común que el linfoma cutáneo de linfocitos B.

Types

The types of cutaneous B-cell lymphoma include:

  • Primary cutaneous follicle center lymphoma. This is the most common type of cutaneous B-cell lymphoma. It appears mostly on the scalp, face, forehead and torso. Primary cutaneous follicle center lymphoma usually grows slowly and has an excellent prognosis.
  • Primary cutaneous marginal zone B-cell lymphoma. This is the second most common type of cutaneous B-cell lymphoma. It appears mostly on the torso, arms and head. Primary cutaneous marginal zone B-cell lymphoma usually grows slowly and has an excellent prognosis. However, this type comes back in about half the people.
  • Primary cutaneous diffuse large B-cell lymphoma, leg type. This is the rarest type of cutaneous B-cell lymphoma. It appears mostly on one or both legs but can be found elsewhere. Primary cutaneous diffuse large B-cell lymphoma, leg type usually grows fast and has a poor prognosis. This type has a high relapse rate and may spread beyond the skin when it comes back.
  • Intravascular diffuse large B-cell lymphoma. This type is different from the other types of cutaneous B-cell lymphoma. It is not limited to the skin but forms in small blood vessels of the skin and elsewhere in the body. Because of this, it can affect any organ. The skin and central nervous system are the most common sites. When in the skin, it appears most often on the legs or torso. Some people may have a fever or have symptoms in the brain before having skin symptoms. Intravascular diffuse large B-cell lymphoma usually grows fast and has a poor prognosis.
Jan. 17, 2025

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  1. Primary cutaneous lymphomas. National Comprehensive Cancer Network. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1491. Accessed Oct. 10, 2024.
  2. Bolognia JL, et al. B-cell lymphomas of the skin. In: Dermatology. 5th ed. Elsevier; 2025. https://www.clinicalkey.com. Accessed Oct. 15, 2024.
  3. Cerroni L, et al. Infection by Borrelia burgdorferi and cutaneous B-cell lymphoma. Journal of Cutaneous Pathology. 1997; doi:10.1111/j.1600-0560.1997.tb01318.x.