Charcot (shahr-KOH)-Marie-Tooth disease is a group of inherited disorders that cause nerve damage. This damage is mostly in your arms and legs (peripheral nerves). Charcot-Marie-Tooth disease is also called hereditary motor and sensory neuropathy.

Charcot-Marie-Tooth disease results in smaller, weaker muscles. You may also experience loss of sensation and muscle contractions, and difficulty walking. Foot deformities such as hammertoes and high arches also are common. Symptoms usually begin in your feet and legs, but they may eventually affect your hands and arms.

Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but may also develop in midlife.


Signs and symptoms of Charcot-Marie-Tooth disease may include:

  • Weakness in your legs, ankles and feet
  • Loss of muscle bulk in your legs and feet
  • High foot arches
  • Curled toes (hammertoes)
  • Decreased ability to run
  • Difficulty lifting your foot at the ankle (footdrop)
  • Awkward or higher than normal step (gait)
  • Frequent tripping or falling
  • Decreased sensation or a loss of feeling in your legs and feet

As Charcot-Marie-Tooth disease progresses, symptoms may spread from the feet and legs to the hands and arms. The severity of symptoms can vary greatly from person to person, even among family members.


Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms.

Sometimes, these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath). Both cause weaker messages to travel between your extremities and brain.

That means some of the muscles in your feet may not receive your brain's signal to contract, so you're more likely to trip and fall. And your brain may not receive pain messages from your feet, so if you've rubbed a blister on your toe, for example, it may get infected without your realizing it.

Risk factors

Charcot-Marie-Tooth disease is hereditary, so you're at higher risk of developing the disorder if anyone in your immediate family has had the disease. Other causes of neuropathies, such as diabetes, may cause symptoms similar to or worsen Charcot-Marie-Tooth disease.

Other causes of neuropathies, such as diabetes, may cause symptoms similar to or worsen those of Charcot-Marie-Tooth disease. Also, medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane, Taxol) and others can make symptoms worse. Be sure to let your doctor know about all of the medications you’re taking.


Complications of Charcot-Marie-Tooth disease vary in severity from person to person. Foot abnormalities and difficulty walking are usually the most serious problems. Muscles may get weaker, and you may injure areas of the body that experience decreased sensation.

You may also experience difficulty breathing, swallowing or speaking if the muscles that control these functions are affected by Charcot-Marie-Tooth disease.

Jan. 11, 2019
  1. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/charcot_marie_tooth/detail_charcot_marie_tooth.htm. Accessed Nov. 16, 2018.
  2. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Nov. 16, 2018.
  3. Simon RP, et al. Sensory Disorders. In: Clinical Neurology. 10th ed. New York, N.Y.: McGraw-Hill Education; 2018. https://accessmedicine.mhmedical.com. Accessed Jan. 3, 2019.
  4. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Nov. 16, 2018.
  5. Ekins S, et al. A brief review of recent Charcot-Marie-Tooth research and priorities. F1000 Research. 2015;4:53. https://f1000research.com/articles/4-53/v1. Accessed Dec. 3, 2015.
  6. Klein CJ (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 17, 2018.
  7. Verma A. Next-generation sequencing and diagnosis of Charcot-Marie-Tooth disease. Annals of Indian Academy of Neurology. 2014;17:383.
  8. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/resource-center/treatment-management/foot-care/important-foot-care-for-people-with-cmt/. Accessed Jan. 29, 2016.
  9. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Jan. 29, 2016.
  10. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Nov. 20, 2018.
  11. Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017;30:471.
  12. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/resource-center/treatment-management/neurotoxic-medications/. Accessed Nov. 27, 2018.


Associated Procedures

Products & Services