An endoscopy procedure involves inserting a long, flexible tube (endoscope) down your throat and into your esophagus. A tiny camera on the end of the endoscope lets your doctor examine your esophagus, stomach and the beginning of your small intestine (duodenum).
Capsule endoscopy camera
During a capsule endoscopy procedure, you swallow a tiny camera that's about the size of a large vitamin pill. The capsule contains lights to illuminate your digestive system, a camera to take images and an antenna that sends those images to a recorder you wear on a belt.
Many people with celiac disease don't know they have it. Two blood tests can help diagnose it:
- Serology testing looks for antibodies in your blood. Elevated levels of certain antibody proteins indicate an immune reaction to gluten.
- Genetic testing for human leukocyte antigens (HLA-DQ2 and HLA-DQ8) can be used to rule out celiac disease.
It's important to be tested for celiac disease before trying a gluten-free diet. Eliminating gluten from your diet might make the results of blood tests appear normal.
If the results of these tests indicate celiac disease, your doctor will likely order one of the following tests:
- Endoscopy. This test uses a long tube with a tiny camera that's put into your mouth and passed down your throat (upper endoscopy). The camera enables your doctor to view your small intestine and take a small tissue sample (biopsy) to analyze for damage to the villi.
- Capsule endoscopy. This test uses a tiny wireless camera to take pictures of your entire small intestine. The camera sits inside a vitamin-sized capsule, which you swallow. As the capsule travels through your digestive tract, the camera takes thousands of pictures that are transmitted to a recorder.
If your doctor suspects you have dermatitis herpetiformis, he or she might take a small sample of skin tissue to examine under a microscope (skin biopsy).
A strict, lifelong gluten-free diet is the only way to manage celiac disease. Besides wheat, foods that contain gluten include:
- Graham flour
- Spelt (a form of wheat)
A dietitian who works with people with celiac disease can help you plan a healthy gluten-free diet. Even trace amounts of gluten in your diet can be damaging, even if they don't cause signs or symptoms.
Gluten can be hidden in foods, medications and nonfood products, including:
- Modified food starch, preservatives and food stabilizers
- Prescription and over-the-counter medications
- Vitamin and mineral supplements
- Herbal and nutritional supplements
- Lipstick products
- Toothpaste and mouthwash
- Communion wafers
- Envelope and stamp glue
- Play dough
Removing gluten from your diet will gradually reduce inflammation in your small intestine, causing you to feel better and eventually heal. Children tend to heal more quickly than adults.
Vitamin and mineral supplements
If your anemia or nutritional deficiencies are severe, your doctor or dietitian might recommend that you take supplements, including:
- Vitamin B-12
- Vitamin D
- Vitamin K
Vitamins and supplements are usually taken in pill form. If your digestive tract has trouble absorbing vitamins, your doctor might give them by injection.
Medical follow-up at regular intervals can ensure that your symptoms have responded to a gluten-free diet. Your doctor will monitor your response with blood tests.
For most people with celiac disease, a gluten-free diet will allow the small intestine to heal. For children, that usually takes three to six months. For adults, complete healing might take several years.
If you continue to have symptoms or if symptoms recur, you might need an endoscopy with biopsies to determine whether your intestine has healed.
Medications to control intestinal inflammation
If your small intestine is severely damaged or you have refractory celiac disease, your doctor might recommend steroids to control inflammation. Steroids can ease severe signs and symptoms of celiac disease while the intestine heals.
Other drugs, such as azathioprine (Azasan, Imuran) or budesonide (Entocort EC, Uceris), might be used.
Treating dermatitis herpetiformis
If you have this skin rash, your doctor might recommend a medication such as dapsone, taken by mouth, as well as a gluten-free diet. If you take dapsone, you'll need regular blood tests to check for side effects.
Refractory celiac disease
If you have refractory celiac disease, your small intestine won't heal. Then you'll likely need to be evaluated in a specialized center. Refractory celiac disease can be quite serious, and there is currently no proven treatment.
Get the latest health information from Mayo Clinic delivered to your inbox.
Subscribe for free and receive your in-depth guide to
digestive health, plus the latest on health innovations and news. You can unsubscribe at any
ErrorEmail field is required
ErrorInclude a valid email address
To provide you with the most relevant and helpful information, and understand which
information is beneficial, we may combine your email and website usage information with
other information we have about you. If you are a Mayo Clinic patient, this could
include protected health information. If we combine this information with your protected
health information, we will treat all of that information as protected health
information and will only use or disclose that information as set forth in our notice of
privacy practices. You may opt-out of email communications at any time by clicking on
the unsubscribe link in the e-mail.
Thank you for subscribing
Your in-depth digestive health guide will be in your inbox shortly. You will also receive
emails from Mayo Clinic on the latest health news, research, and care.
If you don’t receive our email within 5 minutes, check your SPAM folder, then contact us
Sorry something went wrong with your subscription
Please, try again in a couple of minutes
Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
Lifestyle and home remedies
If you've been diagnosed with celiac disease, you'll need to avoid all foods that contain gluten. Ask your doctor for a referral to a dietitian, who can help you plan a healthy gluten-free diet.
Avoid packaged foods unless they're labeled as gluten-free or have no gluten-containing ingredients, including emulsifiers and stabilizers that can contain gluten. In addition to cereals, pastas and baked goods, other packaged foods that can contain gluten include:
- Beers, lagers, ales and malt vinegars
- Imitation meats or seafood
- Processed luncheon meats
- Rice mixes
- Salad dressings and sauces, including soy sauce
- Seasoned snack foods, such as tortilla and potato chips
- Self-basting poultry
Pure oats aren't harmful for most people with celiac disease, but oats can be contaminated by wheat during growing and processing. Ask your doctor if you can try eating small amounts of pure oat products.
Many basic foods are allowed in a gluten-free diet, including:
- Fresh meats, fish and poultry that aren't breaded, batter-coated or marinated
- Most dairy products, unless they make your symptoms worse
- Wine and distilled liquors, ciders and spirits
Grains and starches allowed in a gluten-free diet include:
- Gluten-free flours (rice, soy, corn, potato, bean)
- Pure corn tortillas
- Wild rice
Coping and support
It can be difficult, and stressful, to follow a completely gluten-free diet. Here are some ways to help you cope and to feel more in control.
- Get educated and teach family and friends. They can support your efforts in dealing with the disease.
- Follow your doctor's recommendations. It's critical to eliminate all gluten from your diet.
- Find a support group. You might find comfort in sharing your struggles with people who face similar challenges. Organizations such as the Celiac Disease Foundation, Gluten Intolerance Group, the Celiac Support Association and Beyond Celiac can help put you in touch with others who share your challenges.
Preparing for your appointment
You might be referred to a doctor who treats digestive diseases (gastroenterologist). Here's some information to help you prepare for your appointment.
What you can do
Until your appointment, continue eating a normal diet. Cutting gluten before you're tested for celiac disease can change the test results.
Make a list of:
- Your symptoms, including when they started and whether they've changed over time
- Key personal information, including major stresses or recent life changes and whether anyone in your family has celiac disease or another autoimmune condition
- All medications, vitamins or supplements you take, including doses
- Questions to ask your doctor
For celiac disease, questions to ask your doctor include:
- What's the most likely cause of my symptoms?
- Is my condition temporary or long term?
- What tests do I need?
- What treatments can help?
- Do I need to follow a gluten-free diet?
Don't hesitate to ask other questions.
What to expect from your doctor
Your doctor is likely to ask you questions, including:
- How severe are your symptoms?
- Have they been continuous or occasional?
- What, if anything, seems to improve your symptoms?
- What, if anything, seems to worsen your symptoms?
- What medications and pain relievers do you take?
- Have you been diagnosed with anemia or osteoporosis?
Aug. 10, 2021