Neurology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Blood and Spinal Fluid Collection for Research Studies in Motor Neuron Disease and Motor Neuropathy

   Rochester, Minn.

   The purpose of this study is so that blood (plasma and blood cells) and/or extra spinal fluid (which was taken for clinical purposes) can be obtained and stored for later research on a large cohort of patients with progressive motor neuronopathies and neuropathies, many of which will be determined to suffer from Amyotrophic Lateral Sclerosis (ALS). 

2. Dominantly Inherited Alzheimer Network (DIAN)

   Jacksonville, Fla.

   The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

3. Cerebrospinal Fluid Biomarkers For Brain Tumors

   Rochester, Minn.

   The purpose of this study is to help generate a repository of Cerebrospinal  Fluid (CSF) samples relevant to neuro-oncology research that may facilitate the identification of biomarkers that are predictive of disease burden, therapeutic susceptibility or response to therapy. This protocol will also provide a vehicle for CSF access for patients or providers wishing to generate or evaluate individualized biomarkers as part of other research or individualized therapy protocols.

4. Acute Modulation of Stereotyped High-Frequency Oscillations

   Rochester, Minn.

   The purpose of this study is to do data collection of EEG findings to determine whether new types analysis of intracranial EEG can add different and possibly useful information to standard types of analysis of intracranial EEG. Intracranial EEG data will be collected intraoperatively and postoperatively during routine clinical monitoring, and will be analyzed by researchers for functional brain mapping and the investigation of high frequency oscillations (HFO's), for the purpose of identifying functional and epileptogenic brain areas.  

5. Magnetic Resonance Elastography of Traumatic Brain Injury

   Rochester, Minn.

   This purpose of this pilot study is to determine if there are changes in mild TBI detectible with MRE. This is the first time this novel technology has been applied to mild TBI and the anticipated results are theoretical.

6. Evaluating Optic Nerve Disease with OCT Angiography

   Rochester, Minn.

   The purpose of this study is to determine if optical coherence tomography (OCT) angiography is able to distinguish different causes of optic neuropathy.

7. Sex-Specific Effects Of Endocrine Disruption On Aging And Alzheimer's Disease

   Jacksonville, Fla., Rochester, Minn.

   The researchers are trying to determine whether ovarian hormones are associated with aging processes and with the risk of developing Alzheimer's disease in women.

8. A Study Of Acute Stimulation For The Modulation Of Epileptic Events With A Closed-Loop Brain Interchange System In Drug Resistant Epilepsy

   Rochester, Minn.

   The purpose of this study is to investigate the feasibility of detecting and modulating pathological high-frequency oscillations (HFOs) generated by the seizure onset zone (SOZ) of drug-resistant epilepsy patients using CorTec's Brain Interchange Evaluation Kit (manual provided as supplementary material).

9. A Registry of Biospecimens for Patients with Central Nervous Systems Inflammatory Disease

   Rochester, Minn.

   The purpose of the study is to learn more about inflammatory diseases of the central nervous system (CNS) by collecting patient information, blood sample (which contain a person’s genes, DNA) and other available tissue samples.

10. A Study to Evaluate Biomarker Target Stimulation

    Rochester, Minn.

    The purpose of this study is to understand how electrical stimulation of the brain can modulate and suppress interictal epileptiform activity as a step on the path to developing new therapies for epilepsy.