Clinical trials Below are current clinical trials.87 studies in Surgery (open studies only). Filter this list of studies by location, status and more. A Study to Evaluate Novel Nipple Reconstruction Technique Using Nipple Sharing of a Half-Split Nipple in Female-to-Male Transgender Chest-Wall Contouring Rochester, Minn. The purpose of this study is to describe a new surgical technique for nipple reconstruction in female-to-male transgender chest wall reconstruction and demonstrate its safety, patient satisfaction, aesthetic evaluation and complications. Subsequently, correlate these findings to assess overall surgical and clinical outcomes. Colorectal Resection in Emergency General Surgery Rochester, Minn. The purpose of this study is to define the early postoperative morbidity and mortality of EGS patients undergoing colon resection in the urgent/emergent setting, with a specific focus on the comparison of patients undergoing colonic anastomosis versus diversion. Study to Validate the Use of Hand-Held Mobile 3D Scanning to Obtain Volumetric Measurements for Staging Disease Severity in Lymphedema Patients Jacksonville, Fla. The purpose of this study is to validate the use of LymphaTech's Hand-Held Mobile 3D Scanning to obtain volumetric measurements in order to stage disease severity in patients diagnosed with lymphedema, and also serve as an imaging biomarker for microsurgical treatment response. A Study to Evaluate the Safety and Immunological Effect of Pembrolizumab in Resectable or Borderline Resectable Pancreatic Cancer Scottsdale/Phoenix, Ariz. The purpose of this study is to investigate whether pembrolizumab (MK-3475 ) can be used safely during neoadjuvant treatment and can improve the body's immune response against pancreatic cancer. Pembrolizumab has been approved for treatment of patients with melanoma but has not been proven to be safe or helpful in patients with pancreatic cancer and is not approved by the U.S. Food and Drug Administration (FDA) for this purpose. A Study to Evaluate Vascularized Lymph Node Transfer Coverage Rochester, Minn. The purpose of this study is to investigate outcomes for all patients with upper or lower extremity lymphedema with lymph node transfer in a two stage procedure involving dermal regeneration followed by split thickness skin graft (STSG) and compared to patients only receiving STSG for wound coverage. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial Jacksonville, Fla., Rochester, Minn. Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed. Early Outcomes of Volar Capsulodesis for the Treatment of Scapholunate Ligament Injury Rochester, Minn. The purpose of this study is to: To provide a comprehensive review of Mayo Clinic’s experience with volar SLIL capsulodesis Investigate the relationships between patient risk factors and clinical variables with functional outcomes and patient satisfaction Determine rates of complication, revision surgeries and salvage for failure A Study of Intravital Microscopy (IVM) in Human Solid Tumors Jacksonville, Fla. The purpose of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during standard course of surgical resection. Lobular Involution-Based Response to Antiendocrine Therapy for Women with Breast Atypical Hyperplasia Jacksonville, Fla. The goal of this study is to perform a quantitative measure of lobular involution (qLI) from breast biopsy samples obtained at baseline (surgery) and 12 months or at time of study discontinuation. The study will determine breast density (MMG) and correlate with qLI. The study will also determine the influence of chemoprevention therapies such as tamoxifen and letrozole on qLI. A Study to Evaluate The Negative Predictive Value and Non-irritant Skin Testing Concentrations of Beta-Lactam Containing Antibiotics Other Than Penicillin Jacksonville, Fla. The purpose of this study is to accurately determine the negative predictive value of skin testing with beta-lactams containing antibiotics other than penicillin. 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