Surgery

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Colorectal Resection in Emergency General Surgery

   Rochester, Minn.

   The purpose of this study is to define the early postoperative morbidity and mortality of EGS patients undergoing colon resection in the urgent/emergent setting, with a specific focus on the comparison of patients undergoing colonic anastomosis versus diversion.

2. Study to Validate the Use of Hand-Held Mobile 3D Scanning to Obtain Volumetric Measurements for Staging Disease Severity in Lymphedema Patients

   Jacksonville, Fla.

   The purpose of this study is to validate the use of LymphaTech's Hand-Held Mobile 3D Scanning to obtain volumetric measurements in order to stage disease severity in patients diagnosed with lymphedema, and also serve as an imaging biomarker for microsurgical treatment response.

3. A Study to Evaluate Novel Nipple Reconstruction Technique Using Nipple Sharing of a Half-Split Nipple in Female-to-Male Transgender Chest-Wall Contouring

   Rochester, Minn.

   The purpose of this study is to describe a new surgical technique for nipple reconstruction in female-to-male transgender chest wall reconstruction and demonstrate its safety, patient satisfaction, aesthetic evaluation and complications. Subsequently, correlate these findings to assess overall surgical and clinical outcomes.

4. A Study to Evaluate the Safety and Immunological Effect of Pembrolizumab in Resectable or Borderline Resectable Pancreatic Cancer

   Scottsdale/Phoenix, Ariz., Rochester, Minn., Jacksonville, Fla.

   The purpose of this study is to investigate whether pembrolizumab (MK-3475 ) can be used safely during neoadjuvant treatment and can improve the body's immune response against pancreatic cancer. Pembrolizumab has been approved for treatment of patients with melanoma but has not been proven to be safe or helpful in patients with pancreatic cancer and is not approved by the U.S. Food and Drug Administration (FDA) for this purpose.

5. Early Outcomes of Volar Capsulodesis for the Treatment of Scapholunate Ligament Injury

   Rochester, Minn.

   The purpose of this study is to:

   1. To provide a comprehensive review of Mayo Clinic’s experience with volar SLIL capsulodesis
   2. Investigate the relationships between patient risk factors and clinical variables with functional outcomes and patient satisfaction
   3. Determine rates of complication, revision surgeries and salvage for failure

6. A Study to Evaluate Vascularized Lymph Node Transfer Coverage

   Rochester, Minn.

   The purpose of this study is to investigate outcomes for all patients with upper or lower extremity lymphedema with lymph node transfer in a two stage procedure involving dermal regeneration followed by split thickness skin graft (STSG) and compared to patients only receiving STSG for wound coverage.

    

7. A Study of Intravital Microscopy (IVM) in Human Solid Tumors

   Jacksonville, Fla.

   The purpose of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during standard course of surgical resection.

8. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial

   Jacksonville, Fla., Rochester, Minn.

   Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will randomize patients in a 1:1 ratio to carotid stenting with embolic protection versus no stenting. Medical management will be uniform for all randomized treatment groups and will be centrally directed.

9. A Study of Staging Procedures to Diagnose Malignant Pleural Mesothelioma

   Rochester, Minn.

   The purpose of this study is to compare whether surgical staging is more accurate than imaging procedures when diagnosing malignant lung mesothelioma.

10. A Study of the Quality of Life after Surgery for Recurrent Rectal Cancer

    Rochester, Minn.

    The purpose of this study is to measure the quality and quantity of the lifespan in patients who have locally recurrent rectal cancer. It will compare survival rates and quality of life of those who have surgery to those who do not have surgery. It also aims to compare certain other factors, such as whether clear resection margins (i.e. “R0 margins” which are when no evidence of the tumour is found in the biopsy) were achieved and the influence of chemotherapy and radiotherapy.