Endocrinology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Effect of Fasting, Endogenous GLP-1 Secretion on B-cell Response to Intravenous Glucose

   Rochester, Minn.

   The purpose of this study is to determine the effect of GLP-1 in priming β-cells for insulin secretion.

2. A Study of the Effects of Abnormal Steroid Metabolome on Bone Strength and Quality, Bone Density, Bone Remodeling, and Body Composition in Patients with MACS and Healthy Volunteers

   Rochester, Minn.

   The purpose of this study is to determine the effect of abnormal steroid metabolome on bone strength and quality, bone density, bone remodeling, and body composition in patients with mild autonomous cortisol secretion (MACS) and healthy volunteers.

3. Epidemiology of Diabetes Interventions and Complications (EDIC)

   Rochester, Minn.

   OBJECTIVE— The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications.

   Contemporary prospective data on the evolution of macrovascular and late micro vascular complications of type 1 diabetes are limited. The Epidemiology of Diabetes Interventions and Complications (EDIC) study is a multicenter, longitudinal, observational study designed to use the well-characterized DCCT cohort of 1,400 patients to determine the long-term effects of prior separation of glycemic levels on micro- and macrovascular outcomes. EDIC is in its 13th year of followup. The study is expecting to last until 2016.

   RESEARCH DESIGN AND METHODS— Using a standardized annual history and physical examination, 28 EDIC clinical centers that were DCCT clinics will follow the EDIC cohort for 10 years. Annual evaluation also includes resting electro c a rdiogram, Doppler ultrasound measurements of ankle/arm blood pressure, and screening for nephropathy. At regular intervals, a timed 4-h urine is collected, lipid pro files are obtained, and stereoscopic fundus photographs are taken. In addition, dual B-mode Doppler ultrasound scans of the common and internal carotid arteries will be perf o rmed at years 1 and 6 and at study end.

4. PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism

   Rochester, Minn.

   This is a prospective, observational, natural history registry, designed to collect data on patients with chronic hypoparathyroidism. No study-defined procedures will be required, and if available, a select set of data will be collected at baseline and at least annually.

5. A Pilot Study Examining the Effect of Fasting Free Acid and Glucose Concentrations on Insulin Secretion

   Rochester, Minn.

   The purpose of this study is to determine if changes in fasting glucose and FFA concentrations alter 1st phase insulin secretion and proinsulin secretion in non-diabetic and pre-diabetic humans.
    

6. Role of Intestinal Inflammation in the Pathogenesis of Type 1 Diabetes

   Rochester, Minn.

   This purpose of this study is to determine if activation of a person's immune system in the small intestine could be a contributing cause of Type 1 Diabetes.

7. A Study to Develop a Decision Aid for Patients Having Lung Screening

   Rochester, Minn.

   The purpose of this study is to collect data and then design a decision aid for patients who are having a lung screening.

8. Ga-DOTATATE PET for Localization of Phosphaturic Mesenchymal Tumors in Patients with Tumor Induced Osteomalacia

   Rochester, Minn.

   This study aims to identify cases of FGF23-mediated oncogenic osteoomalacia in which the underlying phosphaturic mesenchymal has not been found and perform 68Ga-DOTATATE PET in these patients to localize the tumor.

9. A Study of the Impact of the Terminology Used to Identify Papillary Thyroid Cancer on the Treatment Options Chosen by Patients

   Rochester, Minn.

   The purpose of this study is to explore how using different terms (with or without the word cancer) to identify papillary thyroid cancer might affect the decisions patients would make about treatment.

10. A Study of the Effects of Inflammation on Fat Tissue and Insulin in People with Different Body Shapes

    Rochester, Minn.

    The purpose of this study is to see why the ability of fat cells to respond to insulin is different depending on body shape and how fat tissue inflammation is involved.