Endocrinology

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Insulin Regulation of Lipolysis and Lipolysis Proteins

   Rochester, Minn.

   The purpose of this study is to determine whether impaired insulin-induced suppression of lipolysis (as measured by IC50) is related to lipolysis proteins in groups of volunteers known to vary widely with regards to abdominal adipocyte size and regulation of adipose tissue lipolysis, and whether the improved insulin regulation of lipolysis resulting from treatment with the PPARγ agonist pioglitazone, with or without weight loss, can be linked to specific changes in sets of PPARγ-responsive adipocyte lipolysis proteins in UBO adults.
   
   
   
    

    

    

    

    

2. A Study to Assess Bone Quality Characteristics, Comparing Type 2 Diabetes Patients who have or have not had Prior Fragile Bone Fractures

   Rochester, Minn.

   The purpose of this study is to assess key characteristics of bone quality, specifically material strength and porosity, in patients who have type 2 diabetes. These patients are at an unexplained increased risk for fractures and there is an urgent need to refine clinical assessment for this risk.

3. A Study of New Laboratory Assays to Develop Better Therapies for Treating Patients with Graves’ Disease

   Rochester, Minn.

   This study is being done to see if better therapies can be developed to treat Graves’ disease, using new laboratory assays

4. Developmental Study-Bone Marrow and Peripheral Blood

   Rochester, Minn.

   This study is being done to assess gene expression in bone marrow and peripheral blood to study cells that control bone metabolism. In order to develop new methods we need samples from healthy volunteers.

5. A Study to Test How Muscle Tissue Differs Between People

   Rochester, Minn.

   The purpose of this study is to look for ways to test how muscle tissue differs between people.

6. Study to Determine the Effectiveness of “The Perfect Waist Circumference Measuring Device"

   Rochester, Minn.

   The purpose of this study is to determine whether abdominal subcutaneous and visceral fat measured by diagnostic imaging correlates with waist circumferences measured by the device.

7. Iodine I-131 With or Without Selumetinib in Treating Patients With Recurrent or Metastatic Thyroid Cancer

   Rochester, Minn.

   This randomized phase II trial studies how well iodine I-131works with or without selumetinib in treating patients with thyroid cancer that has returned or has spread from where it started to other places in the body. Many thyroid cancers absorb iodine. Because of this, doctors often give radioactive iodine (iodine I-131) alone to treat thyroid cancer as part of standard practice. It is thought that the more thyroid tumors are able to absorb radioactive iodine, the more likely it is that the radioactive iodine will cause those tumors to shrink. Selumetinib may help radioactive iodine work better in patients whose tumors still absorb radioactive iodine. It is not yet known whether iodine I-131 is more effective with or without selumetinib in treating thyroid cancer.

8. Epidemiology of Diabetes Interventions and Complications (EDIC)

   Rochester, Minn.

   The purpose of this study is to use the well-characterized Diabetes Control and Complications Trial (DCCT) cohort of 1,400 patients to determine the long-term effects of prior separation of glycemic levels on micro- and macrovascular outcomes.

9. A Pilot Study Examining the Effect of Fasting Free Acid and Glucose Concentrations on Insulin Secretion

   Rochester, Minn.

   The purpose of this study is to determine if changes in fasting glucose and FFA concentrations alter 1st phase insulin secretion and proinsulin secretion in non-diabetic and pre-diabetic humans.
    

10. Pediatric Obesity Weight Evaluation Registry (POWER) Study

    Rochester, Minn.

    The main objective of this study is to establish a national pediatric obesity registry known as POWER (Pediatric Obesity Weight Evaluation Registry). This registry will contain clinical data from individual comprehensive pediatric weight management programs around the United States for overweight and obese youth.