Clinical trials Below are current clinical trials.71 studies in Endocrinology (open studies only). Filter this list of studies by location, status and more. Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus Rochester, Minn. To understand why patients with indigestion with or without diabetes have gastrointestinal symptoms and in particular to understand where the symptoms are related to increased sensitivity to nutrients. Effect of Fasting, Endogenous GLP-1 Secretion on B-cell Response to Intravenous Glucose Rochester, Minn. The purpose of this study is to determine the effect of GLP-1 in priming β-cells for insulin secretion. The BROADEN Study: A Study of Volanesorsen (Formerly ISIS-APOCIIIRx) in Patients With Familial Partial Lipodystrophy Rochester, Minn. The purpose of this study is to evaluate the efficacy and safety of volanesorsen (IONIS-APOCIIIRx) given for 52 weeks in patients with Familial Partial Lipodystrophy. Patients will then be allowed to continue in a 2 year Open Label Extension of the study. Epidemiology of Diabetes Interventions and Complications (EDIC) Rochester, Minn. OBJECTIVE— The Diabetes Control and Complications Trial (DCCT) demonstrated the powerful impact of glycemic control on the early manifestations of microvascular complications. Contemporary prospective data on the evolution of macrovascular and late micro vascular complications of type 1 diabetes are limited. The Epidemiology of Diabetes Interventions and Complications (EDIC) study is a multicenter, longitudinal, observational study designed to use the well-characterized DCCT cohort of 1,400 patients to determine the long-term effects of prior separation of glycemic levels on micro- and macrovascular outcomes. EDIC is in its 13th year of followup. The study is expecting to last until 2016. RESEARCH DESIGN AND METHODS— Using a standardized annual history and physical examination, 28 EDIC clinical centers that were DCCT clinics will follow the EDIC cohort for 10 years. Annual evaluation also includes resting electro c a rdiogram, Doppler ultrasound measurements of ankle/arm blood pressure, and screening for nephropathy. At regular intervals, a timed 4-h urine is collected, lipid pro files are obtained, and stereoscopic fundus photographs are taken. In addition, dual B-mode Doppler ultrasound scans of the common and internal carotid arteries will be perf o rmed at years 1 and 6 and at study end. Sangre Por Salud Biobank Scottsdale/Phoenix, Ariz., Rochester, Minn. There are two purposes for this project. • One purpose of this project is to develop information about Latinos in the Maricopa County area who may be interested in participating in future research studies about health. • A second purpose is that researchers at Mayo Clinic are developing a new research resource called a Biobank. A Biobank is a collection of blood samples and other information. Participants in the Biobank provide samples of blood, complete a health questionnaire, and allow access to medical records now and in the future. A Biobank is as a library for researchers; instead of having to look for volunteers for each new project, researchers can use samples from the Biobank as well as share information already collected. Study to Evaluate CORT125134 in Patients With Cushing's Syndrome Rochester, Minn. Cushing's syndrome is a relatively rare disorder caused by prolonged exposure to high levels of the glucocorticoid hormone cortisol. Cushing's syndrome may result from elevated endogenous or exogenous sources of cortisol. Endogenous Cushing's syndrome resulting from cortisol overproduction by the adrenal glands is the subject of this protocol. Patients with exogenous Cushing's syndrome, which develops as a side effect of chronic administration of high doses of glucocorticoids, are not eligible for enrollment in this study. The purpose of this study is to evaluate the safety and efficacy of CORT125134 for treatment of endogenous Cushing's syndrome. The multicenter study will be conducted in the United States and in Europe. Role of Intestinal Inflammation in the Pathogenesis of Type 1 Diabetes Rochester, Minn. This purpose of this study is to determine if activation of a person's immune system in the small intestine could be a contributing cause of Type 1 Diabetes. Dexamethasone Suppression Test in Healthy Volunteers Rochester, Minn. The purpose of this study is to establish a reference range for free cortisol following dexamethasone administration in 100 volunteers without suspicion of cortisol excess. A Study to Develop a Decision Aid for Patients Having Lung Screening Rochester, Minn. The purpose of this study is to collect data and then design a decision aid for patients who are having a lung screening. Longitudinal Effects of Diabetes-Associated Variation in TCF7L2 on Glucagon and Insulin Secretion in Non-Diabetic Humans Rochester, Minn. The goal of this study is to determine the role of postprandial glucagon suppression and insulin secretion in the progression of glucose intolerance in people with diabetes-associated variation in TCF7L2. 1 2 3 4 5 Next Request an Appointment at Mayo Clinic Locations, travel & lodgingResearch Feb. 21, 2018 Share on: FacebookTwitter EndocrinologySectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsSpecialty groupsLocations, travel & lodgingClinical trialsResearchThe Mayo Clinic experience & patient storiesCosts & insuranceNews from Mayo ClinicResources for physicians Research: It's All About Patients SectionsRequest an appointmentOverviewTests & proceduresConditions treatedDoctorsSpecialty groupsLocations, travel & lodgingClinical trialsResearchThe Mayo Clinic experience & patient storiesCosts & insuranceNews from Mayo ClinicResources for physicians ORG-20392484 Departments & Centers Medical Departments & Centers Endocrinology