Cardiovascular Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Immersive Virtual Reality for Reducing Pain and Anxiety in Patients With Temporary Mechanical Circulatory Support Awaiting Heart Transplantation.

   Jacksonville, Fla.

   Patients awaiting heart transplantation on temporary mechanical support often experience pain and anxiety, and their pre-transplant hospital course is often prolonged. We intend to investigate whether an immersive Virtual Reality headset can improve patients pain and anxiety while awaiting cardiac transplantation using specific patient surveys to assess pain, anxiety, and resilience. 

2. Pulmonary Circulation And Alveolar-Capillary Reserve In Single Ventricle Hearts

   Rochester, Minn.

   The purpose of this study is to investigate alterations in pulmonary vascular physiology and respiratory gas exchange at rest and during exercise (mimicking daily activities) in patients with single ventricle heart disease (SVHD) using novel noninvasive methods developed in our laboratory.

3. Transcatheter Mitral Valve Repair For Inotrope Dependent Cardiogenic Shock (MINOS)

   Rochester, Minn.

   The purpose of this study is to determine if transesophageal echocardiogram repair (TEER) in patients with society for cardiovascular angiography and interventions (SCAI) stage C or D cardiogenic with concomitant moderate or greater mitral regurgitation improve outcomes as compared to medical therapy.

    

4. TRITON-CM: A Study To Evaluate Nucresiran In Patients With Transthyretin Amyloidosis With Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to:
   
   * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events
   * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death
   * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life

5. A Study of Lung Ultrasound to Assess Extravascular Lung Water

   Rochester, Minn.

   The purpose of this study is to determine if lung ultrasound surface wave elastography (LUSWE) can accurately detect changes in lung elasticity (compliance) caused by the presence of extravascular lung water  (pulmonary edema).

6. the Mayo Cardiac Sarcoid Registry

   Rochester, Minn., Jacksonville, Fla.

   Aims, purpose, or objectives:

   1. Develop a retrospective registry of patients with cardiac sarcoidosis
   2. Develop a prospective registry of patients with cardiac sarcoidosis
   3. Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry
   4. Determine risk factors for sarcoid involvement of the heart
   5. Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis
   6. Understand the complications of untreated and treated cardiac sarcoidosis

    

7. A Study of Heart Muscle Elasticity Measured by Echocardiography

   Rochester, Minn.

   The purpose of this study is to evaluate the possibility of using echocardiography to measure heart muscle elasticity in clinical practice.

8. A Study to Assess Non-invasive Arterial Air Plethysmography of Normal and Abnormal Arterial Hemodynamics

   Rochester, Minn.

   The purpose of this study is to determine the accuracy (sensitivity, specificity, negative predictive value, positive predictive value) of a non-invasive arterial air plethysmography prototype in people with normal and abnormal arterial hemodynamics.

9. A Study to Identify the Genetic Defect(s) in Individuals with Arrhythmogenic Bi-Leaflet Mitral Prolapse (aBiMVP)

   Rochester, Minn.

   The purpose of this study is to elucidate the genetic basis of aBiMVP in hopes of determining novel mechanisms that underlie aBiMVP pathogenesis.

10. Hospital Diuretic Therapy and Associated Risk of Heart Failure in Treating Fluid Volume Overload

    Rochester, Minn.

    The objective of this proposal is to assess blood-plasma volume (TBV-PV) status quantitatively in patients with DHF admitted to hospital for volume management, and to determine how effective standard diuretic therapy is in achieving euvolemia and the impact of their quantitated volume status at the time of hospital discharge on heart failure related morality and re-hospitalizations. Thus, to determine if quantitative blood volume analysis could potentially serve as an effective tool to guide more effective in-hospital diuretic therapy to achieve better outcomes in patients hospitalized with clinically identified volume overload.