Cardiovascular Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Predictive Role of Non-Invasive Glucose Assessment During Pregnancy

   Rochester, Minn.

   This study aims to determine the value of regular, non-invasive [glucose] LabClasp monitoring during pregnancy.

2. A Study to Analyze Association of Frequent Premature Ventricular Complex with Stroke or Transient Ischemic Attack

   Rochester, Minn.

   The purpose of this study is to verify that high Premature Ventricular Complex (PVC) burden is associated with increased risk of stroke and/or Transient Ischemic Attack (TIA), to examine outcomes such as stroke/TIA, atrial fibrillation/flutter, and all-cause mortality associated with PVCs, and to evaluate whether PVCs are associated with development of appendage dysfunction.

3. A Study to Evaluate the Burden of Treatment and Illness in Advanced Heart Failure Patients

   Rochester, Minn.

   The primary purpose of this study is to identify which aspects of treatment are most prevalent and burdensome to patients with advanced heart failure.

4. Peripheral Nerve Stimulation Therapy for Atrial Fibrillation

   Rochester, Minn.

   The purpose of this study is to determine and compare the safety and efficacy of transcutaneous afferent patterned stimulation (TAPS) and respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) therapies for the reduction of paroxysmal atrial fibrillation (AF) burden.

5. A Study of Lung Ultrasound to Assess Extravascular Lung Water

   Rochester, Minn.

   The purpose of this study is to determine if lung ultrasound surface wave elastography (LUSWE) can accurately detect changes in lung elasticity (compliance) caused by the presence of extravascular lung water  (pulmonary edema).

6. Expanded Access Protocol of Patisiran for Patients With Hereditary ATTR Amyloidosis (hATTR)

   Rochester, Minn.

   The purpose of this study is to provide expanded access of patisiran to patients with hereditary transthyretin-mediated amyloidosis (hATTR).

7. the Mayo Cardiac Sarcoid Registry

   Rochester, Minn., Jacksonville, Fla.

   Aims, purpose, or objectives:

   1. Develop a retrospective registry of patients with cardiac sarcoidosis
   2. Develop a prospective registry of patients with cardiac sarcoidosis
   3. Understand the natural history of cardiac sarcoidosis through evaluation of outcomes of patients in the registry
   4. Determine risk factors for sarcoid involvement of the heart
   5. Evaluate outcomes of patients both treated and untreated with cardiac sarcoidosis
   6. Understand the complications of untreated and treated cardiac sarcoidosis

    

8. His Bundle Pacing in Bradycardia and Heart Failure

   Rochester, Minn.

   Participants in this study will either have heart failure (HF) and are scheduled to undergo cardiac resynchronization therapy pacemaker (CRT-P) or cardiac resynchronization therapy defibrillator (CRT-D) implantation, or have atrioventricular (AV) block and are scheduled to undergo pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and/or parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block. The hypothesis is that His bundle or parahisian pacing (HISP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF).

9. A Study of Heart Muscle Elasticity Measured by Echocardiography

   Rochester, Minn.

   The purpose of this study is to evaluate the possibility of using echocardiography to measure heart muscle elasticity in clinical practice.

10. A Study to Assess Non-invasive Arterial Air Plethysmography of Normal and Abnormal Arterial Hemodynamics

    Rochester, Minn.

    The purpose of this study is to determine the accuracy (sensitivity, specificity, negative predictive value, positive predictive value) of a non-invasive arterial air plethysmography prototype in people with normal and abnormal arterial hemodynamics.