Cardiovascular Medicine

Below are current clinical trials.

Filter this list of studies by location, status and more.

1. Complex Aortic Aneurysm Repair With Fenestrated Stent Grafts

   Rochester, Minn.

   This study will compare two groups of subjects with complex abdominal aortic aneurysms. It will compare their clinical outcomes and quality of life measures. The group being treated in this study will have their aneurysms repaired by an endovascular approach using Zenith® Fenestrated AAA Endovascular Graft. This group will be compared to a group of 461 patients (historical cohort) whose complex aneurysms were treated by open surgical repair.

2. A Study to Determine the Impact of Individualized Estrogen Therapy on Cardiovascular Disease Risk Parameters in Young Women after Bilateral Oophorectomy

   Rochester, Minn.

   The purpose of this study is to compare the cardiovascular function in young women (<46 years) following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml), to characterize the relationship between the serum estradiol level and cardiovascular function in young women (<46 years) on estradiol replacement after bilateral oophorectomy, and to compare the body composition in young women following bilateral oophorectomy who are treated with either the standard dose of estradiol (100 mcg transdermal patch or equivalent oral dose) or titrated estradiol dosing to achieve average premenopausal estradiol level (80-120 pg/ml).

3. Study to Provide Normal Reference Values for Cardiac Magnetic Resonance Elastography

   Rochester, Minn.

   The purpose of this study is to provide normal reference values for cardiac magnetic resonance elastography.

4. A Study of Mechanisms of Altered Ventilatory Control in Heart Failure

   Rochester, Minn.

   This study is being done because the investigators are trying to understand how feedback from the muscles can influence your blood pressure and breathing during exercise, and if the investigators can reduce this response in heart failure patients. The investigators are also trying to determine ways to improve tolerance to exercise in heart failure patients.

5. A Study Testing the Philips Scanner Technology for Reliable Respiratory Assessment

   Rochester, Minn.

   The purpose of this study is to test the Philips Camera bar code scanner with actual patients, to assess its effectiveness in measuring breaths inspite of common obstructions.

6. A Study to Evaluate Home Monitoring of Post-Discharge Congestive Heart Failure Patients

   Rochester, Minn.

   The primary purpose of this study is to collect long-term (2-month duration) data with the ADI CHF Device on patients at home to demonstrate effectiveness of the device in accurately measuring biologically relevant parameters and detecting fluid status as compared to the standard of care (weight scale).

7. A Study of the Mayo Clinic College of Medicine Ultrasound System

   Rochester, Minn.

   The purpose of this study is is to assess the EPIQ-Affiniti and NG Compact ultrasound systems in a clinical environment and collect clinical data and feedback when compared to the site’s standard ultrasound system.

8. A Study to Evaluate Sacubitril-Valsartan for Left Ventricular Reverse Remodeling in Adults with Congenital Heart Abnormality

   Rochester, Minn.

   The purpose of this study is to determine the optimal medical therapy to improve left ventricular (LV) function. Improvement in LV function has the potential to reduce the burden of heart failure and improve clinical outcomes in the Tetralogy of Fallot (TOF) population.

9. A Study to Evaluate the Effectiveness and Safety of G10 in Subjects with Transthyretin Amyloid Cardiomyopathy

   Rochester, Minn.

   The purpose of this study is to evaluate AG10 800 mg compared to placebo in subjects with symptomatic Transthyretin Amyloid Cardiomyopathy (ATTR-CM).

10. Study to Assess the Decline in Cognitive Function Using Standardized Neurocognitive Assessment in Atrial Fibrillation Patients Treated with Apixaban Versus Warfarin

    Rochester, Minn.

    The purpose of this study is to assess the decline in cognitive function using standardized neurocognitive assessment in Atrial Fibrilation patients treated with Apixaban vs Warfarin.