Search for a doctor

Mark D. Tyson, II, M.D., M.P.H.

  1. Urologist

Departments

Location

  1. Phoenix, Arizona

Languages

English

Mark D. Tyson II, M.D., is a urologic oncologist, with subspecialty interest in bladder cancer. His clinical focus includes:

  • Treatments for muscle invasive and nonmuscle invasive bladder cancer.
  • Robotic, open, and single port cystectomy
  • Ileal conduits and orthotopic neobladders
  • Intravesical therapy for nonmuscle invasive bladder cancer
  • Understanding and improving quality of life for patients with bladder cancer
  • Blue light cystoscopy.

In addition to his clinical activities, Dr. Tyson is active in research and education, providing mentorship to trainees. He authors expert content and publishes regularly in scientific journals. He is currently recruiting patients for multiple clinical trials for patients with bladder cancer:

  • CXB-01 - A randomized cross-over study to evaluate patient preference and satisfaction with urine-based molecular testing versus cystoscopy for surveillance for nonmuscle invasive bladder cancer.
  • Sunrise 3 - A phase III open-label, multi-center, randomized study evaluating the efficacy and safety of TAR-200 in combination with cetrelimab versus intravesical BCG in participants with BCG-naïve high-risk nonmuscle invasive bladder cancer
  • BOND-003: A phase III study of CG0070 in patients with nonmuscle invasive bladder cancer unresponsive to BCG
  • KEYNOTE-676 Cohort A and Cohort B: A phase III, randomized comparator-controlled clinical trial to study the efficacy and safety of Pembrolizumab (MK-3475) in combination with Bacillus Calmette-Guerin (BCG) in participants with high-risk non-muscle invasive bladder cancer that is either persistent or recurrent following BCG induction (Cohort A) or that is naïve to BCG treatment (Cohort B).
  • PATOPSCO - A Phase IIIb open-label, single arm, multi-center US study of BCG administered in combination with Durvalumab in adult BCG-naïve, high-risk nonmuscle invasive bladder cancer participants.
  • PIVOT-006 - A phase III randomized study of CG0070 versus observation for the treatment of intermediate risk non-muscle invasive bladder cancer following transurethral resection of bladder tumor.
  • EV-104 - A study of intravesical enfortumab vedotin for treatment of patients with nonmuscle invasive bladder cancer.
  • TARA-002 - A phase 1b/2 dose expansion open-label study to evaluate safety and anti-tumor activity of intravesical instillation of TARA-002 in adults with high grade nonmuscle invasive bladder cancer. 
  • SWOG S1602: A phase III randomized trial to evaluate the influence of BCG strain differences and T-cell priming with intradermal BCG before intravesical therapy for BCG-naive high-grade non-muscle invasive bladder cancer.
  • TAR-200-103: A multicenter study evaluating safety and efficacy of TAR-200 in subjects with muscle-invasive urothelial carcinoma of the bladder who are ineligible for or refuse cisplatin-based chemotherapy and who are unfit for radical cystectomy.
  • UGN-102: A phase IIb, single-arm, multicenter trial to evaluate the efficacy and safety of UGN-102 as a chemoablation agent in patients with low grade non-muscle invasive bladder cancer at intermediate risk of recurrence.

Dr. Tyson also provides second opinions remotely for newly diagnosed bladder and testis cancers.

  1. Bladder removal
  2. Neobladder reconstruction
  3. Orchiectomy
  4. Retroperitoneal lymph node dissection for testicular cancer
  5. Robotic prostatectomy
  6. Urinary conduit surgery
  • Urothelial carcinoma — bladder cancer and upper tract cancer
  • Testis cancer
  1. 2018
    MPH - Epidemiology and BiostatisticsHarvard T. H. Chan School of Public Health
  2. 2017
    Fellow - Urologic OncologyDepartment of Urologic Surgery, Vanderbilt University School of Medicine
  3. 2011
    ResidentSurgery - Preliminary Residency, Surgery, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
  4. 2010
    MD - HonorsDartmouth Medical School
  5. 2006
    BS - Molecular and Cellular Biology, Honors, Magna Cum LaudeUniversity of Arizona

Certifications

  1. 2019
    UrologyAmerican Board of Urology

Awards and honors

  1. 2023
    Third Place Overall Essay Winner99th Annual Meeting, Western Section, American Urological Association
  2. 2023
    Best in Session Poster99th Annual Meeting, Western Section, American Urological Association
  3. 2022
    Educator of the Year Award (Research)Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Department of Education Administration
  4. 2022
    2022 Top Performing Provider Patient Experience AwardOffice of Mayo Clinic Experience, Mayo Clinic Arizona
  5. 2021
    2021 Top Performing Provider Patient Experience AwardOffice of Mayo Clinic Experience, Mayo Clinic Arizona
  6. 2020
    2020 Top Performing Provider Patient Experience AwardOffice of Mayo Clinic Experience, Mayo Clinic Arizona
  7. 2019
    Educator of the Year Award (Research)Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Department of Education Administration
  8. 2018
    Kern Scholar, Science of Health Care Delivery Mayo Clinic
  9. 2018
    Christian Haub Family Career Development Award in Cancer ResearchMayo Clinic
  10. 2017
    Best Paper, Resident CornerEuropean Urology
  11. 2017
    Best ReviewerThe Journal of Urology
  12. 2013
    1st Prize, Health Policy Resident Essay ContestWSAUA
  13. 2013
    Mayo ScholarMayo Clinic Foundation
  14. 2009
    Alpha Omega AlphaAlpha Omega Alpha Honor Medical Society
  15. 2006
    Magna Cum LaudeUniversity of Arizona
  16. 2005
    Phi Beta Kappa Honor SocietyUniversity of Arizona

Professional memberships

  1. 2023 - present
    Vice ChairSurgical and Procedural Committee, Clinical Practice Committee - Arizona, Executive Operations Team - Arizona
  2. 2023 - present
    MemberEducation Committee, Society of Urologic Oncology
  3. 2022 - present
    Panel MemberProstate Cancer Early Detection, Guidelines, National Comprehensive Cancer Network
  4. 2022 - present
    ReviewerUpper Tract Urothelial Carcinoma, Guidelines, American Urological Association
  5. 2022 - present
    ReviewerEarly Detection for Prostate Cancer, Guidelines, Society of Urologic Oncology and American Urological Association
  6. 2020 - present
    MemberWestern Urologic Forum
  7. 2020 - present
    MemberInstitutional Review Board - Wednesday - Mayo Clinic, Institutional Review Board, Mayo Clinic Committees
  8. 2020 - present
    MemberProgram Evaluation Committee, Urology Residency Program, Mayo School of Graduate Medical Education
  9. 2019
    Video Abstract ReviewerUTUC & Testis, AUA Annual Meeting, American Urological Association
  10. 2018
    Video Abstract ReviewerUTUC & Testis, AUA Annual Meeting, American Urological Association
  11. 2018 - present
    MemberPatient Safety Incident Review Group - AZ, Patient Safety Subcommittee, Continuous Improvement Committee
  12. 2018 - present
    ChairSurgical Quality Subcommittee, Surgical and Procedural Committee, Clinical Practice Committee - Arizona
  13. 2018 - present
    MemberInfection Prevention and Control Subcommittee, Clinical Practice Committee - Arizona, Executive Operations Team - Arizona
  14. 2018 - present
    ChampionSurgical Champion for Mayo Clinic in Arizona, National Surgical Quality Improvement Program, American College of Surgeons
  15. 2017 - present
    MemberBladder Cancer Think Tank, Bladder Cancer Advocacy Network
  16. 2017 - present
    MemberGenitourinary Disease Oriented Group (GU DOG), Department of Urology
  17. 2017 - present
    MemberLower Genitourinary Disease Oriented Group (DOG), Mayo Clinic Task Forces/Work Groups
  18. 2017 - present
    MemberSurgical Quality Subcommittee, Surgical and Procedural Committee, Clinical Practice Committee - Arizona
  19. 2017 - present
    MemberClinical Competency Committee, Urology Residency Program, Mayo School of Graduate Medical Education
  20. 2015 - present
    MemberSociety of Urologic Oncology
  21. 2015 - present
    MemberVanderbilt Urological Society
  22. 2010 - present
    MemberAmerican Urological Association
  23. 2010 - present
    MemberWestern Section American Urological Association
  24. 2010 - present
    MemberArizona Urological Society
  25. 2010 - present
    MemberPhoenix Urologic Society
  26. 2005 - 2006
    Lab Teaching Assistant/InstructorUniversity of Arizona

Publications