Biographical summary
Mark D. Tyson II, M.D., is a urologic oncologist, with subspecialty interest in bladder cancer. His clinical focus includes:
- Treatments for muscle invasive and nonmuscle invasive bladder cancer.
- Robotic, open, and single port cystectomy
- Ileal conduits and orthotopic neobladders
- Intravesical therapy for nonmuscle invasive bladder cancer
- Understanding and improving quality of life for patients with bladder cancer
- Blue light cystoscopy.
In addition to his clinical activities, Dr. Tyson is active in research and education, providing mentorship to trainees. He authors expert content and publishes regularly in scientific journals. He is currently recruiting patients for multiple clinical trials for patients with bladder cancer:
- SWOG S1602: A phase III randomized trial to evaluate the influence of BCG strain differences and T-cell priming with intradermal BCG before intravesical therapy for BCG-naive high-grade non-muscle invasive bladder cancer.
- TAR-200-103: A multicenter study evaluating safety and efficacy of TAR-200 in subjects with muscle-invasive urothelial carcinoma of the bladder who are ineligible for or refuse cisplatin-based chemotherapy and who are unfit for radical cystectomy.
- UGN-102: A phase IIb, single-arm, multicenter trial to evaluate the efficacy and safety of UGN-102 as a chemoablation agent in patients with low grade non-muscle invasive bladder cancer at intermediate risk of recurrence.
- KEYNOTE-676 Cohort A and Cohort B: A phase III, randomized comparator-controlled clinical trial to study the efficacy and safety of Pembrolizumab (MK-3475) in combination with Bacillus Calmette-Guerin (BCG) in participants with high-risk non-muscle invasive bladder cancer that is either persistent or recurrent following BCG induction (Cohort A) or that is naïve to BCG treatment (Cohort B).
- ALLIANCE A031803: A phase II trial of intravesical Gemcitabine and MK-3475 (Pembrolizumab) in the treatment of patients with BCG-unresponsive non-muscle invasive bladder cancer.
- BOND 003: A phase III study of CG0070 in patients with nonmuscle invasive bladder cancer unresponsive to BCG.
- CISTO: The comparison of intravesical therapy and surgery as treatment options for bladder cancer study.
Dr. Tyson also provides second opinions remotely for newly diagnosed bladder and testis cancers.
Conditions treated
Procedures performed
Interests
- Urothelial carcinoma — bladder cancer and upper tract cancer
- Renal cell carcinoma
- Prostate cancer
- Testis cancer
Mayo Clinic locations
Education
- 2018
MPH - Epidemiology and BiostatisticsHarvard T. H. Chan School of Public Health
- 2017
Fellow - Urologic OncologyDepartment of Urologic Surgery, Vanderbilt University School of Medicine
- 2011
ResidentSurgery - Preliminary Residency, Surgery, Programs in Arizona, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine
- 2010
MD - HonorsDartmouth Medical School
- 2006
BS - Molecular and Cellular Biology, Honors, Magna Cum LaudeUniversity of Arizona
Activities and honors
Certifications
- 2019
UrologyAmerican Board of Urology
Awards and honors
- 2022
Educator of the Year Award (Research)Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Department of Education Administration
- 2021
2021 Top Performing Provider Patient Experience AwardOffice of Mayo Clinic Experience, Mayo Clinic Arizona
- 2020
2020 Top Performing Provider Patient Experience AwardOffice of Mayo Clinic Experience, Mayo Clinic Arizona
- 2019
Educator of the Year Award (Research)Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Department of Education Administration
- 2018
Kern Scholar, Science of Health Care Delivery Mayo Clinic
- 2018
Christian Haub Family Career Development Award in Cancer ResearchMayo Clinic
- 2017
Best Paper, Resident CornerEuropean Urology
- 2017
Best ReviewerThe Journal of Urology
- 2013
1st Prize, Health Policy Resident Essay ContestWSAUA
- 2013
Mayo ScholarMayo Clinic Foundation
- 2009
Alpha Omega AlphaAlpha Omega Alpha Honor Medical Society
- 2006
Magna Cum LaudeUniversity of Arizona
- 2005
Phi Beta Kappa Honor SocietyUniversity of Arizona
Professional memberships
- 2023 - present
Education Committee, Society of Urologic Oncology
- 2022 - present
Prostate Cancer Early Detection, Guidelines, National Comprehensive Cancer Network
- 2022 - present
Upper Tract Urothelial Carcinoma, Guidelines, American Urological Association
- 2022 - present
Early Detection for Prostate Cancer, Guidelines, Society of Urologic Oncology and American Urological Association
- 2020 - present
Western Urologic Forum
- 2020 - present
Institutional Review Board - Wednesday - Mayo Clinic, Institutional Review Board, Mayo Clinic Committees
- 2019
UTUC & Testis, AUA Annual Meeting, American Urological Association
- 2018
UTUC & Testis, AUA Annual Meeting, American Urological Association
- 2018 - present
Patient Safety Incident Review Group - AZ, Patient Safety Subcommittee, Continuous Improvement Committee
- 2018 - present
Surgical Quality Subcommittee, Surgical and Procedural Committee, Clinical Practice Committee - Arizona
- 2018 - present
Infection Prevention and Control Subcommittee, Clinical Practice Committee - Arizona, Executive Operations Team - Arizona
- 2018 - present
Surgical Champion for Mayo Clinic in Arizona, National Surgical Quality Improvement Program, American College of Surgeons
- 2017 - present
Bladder Cancer Think Tank, Bladder Cancer Advocacy Network
- 2017 - present
Genitourinary Disease Oriented Group (GU DOG), Department of Urology
- 2017 - present
Lower Genitourinary Disease Oriented Group (DOG), Mayo Clinic Task Forces/Work Groups
- 2017 - present
Surgical Quality Subcommittee, Surgical and Procedural Committee, Clinical Practice Committee - Arizona
- 2017 - present
Clinical Competency Committee, Urology Residency - Arizona, Mayo Clinic School of Graduate Medical Education
- 2015 - present
Society of Urologic Oncology
- 2015 - present
Vanderbilt Urological Society
- 2010 - present
American Urological Association
- 2010 - present
Western Section American Urological Association
- 2010 - present
Arizona Urological Society
- 2010 - present
Phoenix Urologic Society
- 2005 - 2006
University of Arizona
Publications