Madeleine B. O'Keefe, M.D.

Madeleine Barbara O'Keefe, M.D., is a pediatric hematologist/oncologist at Mayo Clinic in Rochester, Minnesota, where she cares for children and adolescents with blood cancers and related conditions. Dr. O'Keefe provides family-centered care for individuals with leukemia and lymphoma, guiding patients and their families through diagnosis, treatment, and survivorship. She works closely with a multidisciplinary team to deliver therapies tailored to each child's unique condition while advancing research to improve outcomes and quality of life for young patients in Rochester and surrounding areas.

Areas of expertise

Dr. O'Keefe's clinical and research interests focus on pediatric blood cancers and treatment-related outcomes.

• Acute lymphoblastic leukemia (ALL): Diagnosis, risk-stratified therapy, and long-term treatment optimization for children and adolescents.
• Acute myeloid leukemia (AML): Genetic and epigenetic study of pediatric AML to support precision-based care.
• Hodgkin's lymphoma: Comprehensive management of pediatric and adolescent patients undergoing chemotherapy or combination therapy.
• Non-Hodgkin's lymphoma: Collaborative care for complex and relapsed disease in children and young adults.
• Treatment-related toxicity: Identification and reduction of toxicities from commonly used chemotherapy agents.
• Adolescent and young adult (AYA) cancer care: Coordination of age-appropriate treatment and survivorship planning.

Research and expertise

Dr. O'Keefe's research centers on improving therapies and reducing treatment-related toxicities for pediatric hematologic malignancies, especially acute lymphoblastic and myeloid leukemias. She has contributed to national Children's Oncology Group (COG) clinical trials and collaborative research evaluating the genomic features of pediatric AML. At Mayo Clinic, she leads and co-leads working groups focusing on optimizing leukemia therapy and enhancing collaboration across pediatric and adult oncology programs.

Board certified by the American Board of Pediatrics in general pediatrics and pediatric hematology/oncology, Dr. O'Keefe completed her medical degree, residency, and fellowship training at the Medical College of Wisconsin and Baylor College of Medicine. She serves as Assistant Professor of Pediatrics at Mayo Clinic College of Medicine and Science.