Print Mayo Clinic's approachAt Mayo Clinic, healthcare professionals who perform cosmetic procedures draw upon their vast experience to help provide exactly the treatment and care you need. TeamworkMayo Clinic uses a team-based model of care so that a doctor who specializes in conditions of the skin, called a dermatologist, may consult with other specialists as needed to address all your concerns. And most medical services you might need are available under one roof. Your team tries to coordinate these services in a way that's convenient and efficient for you. The clinic also offers a regenerative cosmetic service that brings together facial plastic surgeons, dermatologists, vascular surgeons and other healthcare professionals to deliver services grounded in scientific evidence and the latest regenerative technologies. Expertise and rankings Expertise. At Mayo Clinic, facial-filler treatments for wrinkles are done only by board-certified healthcare professionals. Clinical training in the use of facial fillers is essential to prevent or treat complications. If your injection blocks a blood vessel that leads to a part of the eye called the retina, you'll need quick treatment to prevent blindness. Breaking up the blockage involves injecting a substance called hyaluronidase. If the need arises, you have access to all of Mayo's experts and facilities. Time for you. Your Mayo Clinic specialist takes the time to discuss options and answer your questions about facial fillers. Locations, travel and lodgingMayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states. For more information on visiting Mayo Clinic, choose your location below: Mayo Clinic's campus in Arizona Mayo Clinic's campus in Florida Mayo Clinic's campus in Minnesota Mayo Clinic Health System Mayo Clinic Healthcare, located in London Costs and insuranceMayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people. In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need. Learn more about appointments at Mayo Clinic. Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card. Facial-fillers for wrinkles are considered a cosmetic procedure and aren't usually covered by insurance. Exceptions might be made, for example, for people with human immunodeficiency virus (HIV) who undergo the procedure to restore facial fat. More information about billing and insurance: Mayo Clinic in Arizona, Florida and Minnesota Mayo Clinic Health System By Mayo Clinic Staff Request an appointment Doctors & Departments July 15, 2025 Print Show references AskMayoExpert. Soft tissue fillers and other injectables. Mayo Clinic; 2020. Kelly AP, et al., eds. Postinflammatory hyperpigmentation/periorbital hyperpigmentation. In: Taylor and Kelly's Dermatology for Skin of Color. 2nd ed. McGraw Hill; 2016. https://accessmedicine.mhmedical.com. Accessed Dec. 13, 2023. Medical review (expert opinion). Mayo Clinic. May 3, 2023. Dermal filler do's and don'ts for wrinkles, lips and more. U.S. Food and Drug Administration. https://www.fda.gov/consumers/consumer-updates/dermal-filler-dos-and-donts-wrinkles-lips-and-more. Accessed Sept. 20, 2023. Carruthers J, et al., eds. Introduction to temporary fillers: Pros and cons. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Sept. 20, 2023. Desmond Markey J, et al. Advances in nonsurgical periocular rejuvenation. Facial Plastic Surgery Clinics of North America. 2022; doi:org/10.1016/j.fsc.2022.03.006. Health Education & Content Services. Smoothing wrinkles and scars by soft tissue augmentation. Mayo Clinic; 2017. Carruthers J, et al., eds. Complications of temporary fillers. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Carruthers J, et al., eds. Bellafill. In: Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Carruthers J, et al., eds. Poly-L-lactic acid. In Procedures in Cosmetic Dermatology: Soft Tissue Augmentation. 5th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Dec. 13, 2023. Fillers: FAQs. American Academy of Dermatology. https://www.aad.org/public/cosmetic/wrinkles/fillers-faqs. Accessed Dec. 13, 2023. Chesnut, C. Restoration of visual loss with retrobulbar hyaluronidase injection after hyaluronic acid filler. Dermatologic Surgery. 2018; doi:10.1097/DSS.0000000000001237. Carruthers J, et al. Injectable soft tissue fillers: Overview of clinical use. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023. Carruthers J, et al. Injectable soft tissue fillers: Permanent agents. https://www.uptodate.com/contents/search. Accessed Dec. 19, 2023. Related Wrinkles Products & Services A Book: Mayo Clinic Family Health Book Assortment of Health Products from Mayo Clinic Store Newsletter: Mayo Clinic Health Letter — Digital Edition Show more products and services from Mayo Clinic Facial fillers for wrinklesAboutDoctors&DepartmentsCare atMayoClinic PRC-20394066 Tests & Procedures Facial fillers for wrinkles