Mayo Clinic's approach


The Transgender and Intersex Specialty Care Clinic (TISCC) provides integrated medical, psychosocial and surgical intervention to individuals with gender dysphoria or incongruence and to those with differences of sexual development, also called intersex. The team includes providers from various specialties including endocrinology, pediatric endocrinology, social work, psychiatry, psychology, voice therapy, gynecology, urology and plastic surgery.

Treatments offered include:

  • Behavioral health assessment and management
  • Gender-affirming hormone therapy
  • Assistance with social and legal issues and referrals to community resources
  • Fertility preservation
  • Referrals for sexually transmitted infection screening and preexposure prophylaxis (PrEP)
  • Gender-affirming voice therapy
  • Electrolysis and laser hair removal
  • Hair transplant
  • Gynecological care for trans men
  • Chaplain services
  • Preoperative and postoperative pelvic floor physical therapy
  • Feminizing surgical procedures:
    • Breast augmentation
    • Facial feminization
    • Tracheal shave
    • Body-contouring procedures
    • Orchiectomy
    • Vaginoplasty and labioplasty
    • Robot-assisted peritoneal flap vaginoplasty
  • Masculinizing surgical procedures:
    • Mastectomy with chest masculinization
    • Body-contouring procedures
    • Hysterectomy and oophorectomy
    • Metoidioplasty

Before you start treatment, you meet with at least one member of the TISCC medical team — a physician, a physician assistant or a nurse practitioner — and a member of the TISCC mental health team, such as a social worker, psychologist or psychiatrist. You have a complete medical evaluation to make sure that your treatment risks are identified and addressed. Before a surgical procedure, you're seen by the appropriate TISCC surgical team. Evaluation of your mental health ensures that any mood or mental health concerns are reasonably well managed before you start treatment.

Each person is different. Your providers look at your specific case to make the best recommendations for you. Your health care team works with you during your treatment to make sure your expectations are realistic. Your team wants to be sure your goals are being met, any risks are managed and your questions are answered.

Advanced technology

Mayo Clinic specialists are committed to providing the latest, most comprehensive treatment options for gender dysphoria. Your Mayo Clinic specialist's advice about the best treatment for you is based on expert knowledge of and experience with all treatment options for gender dysphoria.

Expertise and rankings

At Mayo Clinic, endocrinologists, psychiatrists, psychologists, nurse practitioners, social workers and surgeons work together to provide the care you need.

Having all of this expertise in a single place, focused on you, means that you're not just getting one opinion. Your care is discussed among the team, your test results are available quickly and your appointments are scheduled in coordination. Highly specialized experts are all working together to help determine what's best for you.

Mayo Clinic Children's Center

Highly skilled pediatric experts diagnose and treat all types of conditions in children. As a team, we work together to find answers, set goals and develop a treatment plan tailored to your child's needs.

Learn more about the Children's Center.

Locations, travel and lodging

Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.

For more information on visiting Mayo Clinic, choose your location below:

Costs and insurance

Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.

In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals, or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.

Learn more about appointments at Mayo Clinic.

Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

Clinical trials

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Feb. 21, 2023
  1. Tangpricha V, et al. Transgender women: Evaluation and management. Accessed Oct. 10, 2022.
  2. Erickson-Schroth L, ed. Medical transition. In: Trans Bodies, Trans Selves: A Resource by and for Transgender Communities. 2nd ed. Kindle edition. Oxford University Press; 2022. Accessed Oct. 10, 2022.
  3. Coleman E, et al. Standards of care for the health of transgender and gender diverse people, version 8. International Journal of Transgender Health. 2022; doi:10.1080/26895269.2022.2100644.
  4. AskMayoExpert. Gender-affirming hormone therapy (adult). Mayo Clinic; 2022.
  5. Nippoldt TB (expert opinion). Mayo Clinic. Sept. 29, 2022.

Feminizing hormone therapy