Convalescent plasma therapy

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Research

Mayo Clinic healthcare professionals and researchers continue to study COVID-19 convalescent plasma therapy as it is used to treat people with a weakened immune system. Researchers also are exploring the ways convalescent plasma can help respond to future pandemics.

Publications

See a list of publications about convalescent plasma therapy by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

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By Mayo Clinic Staff

Convalescent plasma therapy care at Mayo Clinic

AboutCare at Mayo Clinic
Dec. 30, 2025
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  1. Investigational COVID-19 convalescent plasma. U.S. Food and Drug Administration. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/investigational-covid-19-convalescent-plasma. Accessed March 24, 2025.
  2. Hoffman R, et al. Principles of plasma and plasma derivatives. In: Hematology. 8th edition. Elsevier. 2023. https://www.clinicalkey.com. Accessed March 24, 2025.
  3. Marano G, et al. Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion. 2016; doi:10.2450/2015.0131-15.
  4. Emergency use authorization. U.S. Food and Drug Administration. https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization. Accessed March 24, 2025.
  5. AskMayoExpert. COVID-19: Outpatient management. Convalescent Plasma. Mayo Clinic; 2025.
  6. Rajendran K, et al. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. Journal of Medical Virology. 2020; doi:10.1002/jmv.25961.
  7. Senefeld JW, et al. COVID-19 Convalescent plasma for the treatment of immunocompromised patients: A systematic review and meta-analysis. Journal of the American Medical Association: Network Open. 2023; doi:10.1001/jamanetworkopen.2022.50647.
  8. COVID-19 treatments and medications. Centers for Disease Control and Prevention. https://www.cdc.gov/covid/treatment/?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/your-health/treatments-for-severe-illness.html#cdc_treatment_overview-covid-19-treatment-options. Accessed March 24, 2025.
  9. Kim AY et al. Coronavirus disease 2019 (COVID-19): Management in hospitalized adults. https://www.uptodate.com/contents/search. Accessed March 24, 2025.
  10. Infectious disease, HLA and ABO donor qualification testing. American Red Cross. https://www.redcrossblood.org/biomedical-services/blood-diagnostic-testing/blood-testing.html. Accessed March 24, 2025.
  11. Medical review (expert opinion). Mayo Clinic. March 24, 2025.
  12. Whole Blood and blood components (Convalescent Plasma, High Titer, Anti-SARS-CoV-2 (Whole Blood-derived) and Apheresis Convalescent Plasma, High Titer, Anti-SARS-CoV-2). https://www.fda.gov/vaccines-blood-biologics/whole-blood-and-blood-components-convalescent-plasma-high-titer-anti-sars-cov-2-whole-blood-derived. Accessed April 4, 2025.
  13. Dragotakes Q, et al. Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma. Proceedings of the National Academy of Sciences of the United States of America. 2024; doi:10.1073/pnas.2414957121.

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Convalescent plasma therapy