Mayo Clinic researchers are studying the use of COVID-19 convalescent plasma therapy. They are focusing on people in the hospital for COVID-19 and people with severely weakened immune systems who have COVID-19.

The goal is to determine if COVID-19 convalescent plasma therapy improves the chance of recovery for people with the most severe disease. They also plan to test whether COVID-19 convalescent plasma can help keep people who are moderately sick from getting sicker. And they will test COVID-19 convalescent plasma to see if it helps prevent the need for hospitalization.

Find out more about COVID-19 research at Mayo Clinic.


See a list of publications about convalescent plasma therapy by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine.

Research Profiles

Edit search filters

Narrow your search

View all physicians • Florida

Convalescent plasma therapy care at Mayo Clinic

July 21, 2023
  1. Investigational COVID-19 convalescent plasma. U.S. Food and Drug Administration. Accessed May 2, 2023.
  2. Hoffman R, et al. Principles of plasma and plasma derivatives. In: Hematology. 8th edition. Elsevier. 2023. Accessed May 2, 2023.
  3. Marano G, et al. Convalescent plasma: New evidence for an old therapeutic tool? Blood Transfusion. 2016; doi:10.2450/2015.0131-15.
  4. Emergency use authorization. U.S. Food and Drug Administration. Accessed May 2, 2023.
  5. AskMayoExpert. Convalescent Plasma. Mayo Clinic; 2023.
  6. COVID-19 convalescent plasma. National Institutes of Health. Accessed May 2. 2023.
  7. Rajendran K, et al. Convalescent plasma transfusion for the treatment of COVID-19: Systematic review. Journal of Medical Virology. 2020; doi:10.1002/jmv.25961.
  8. Senefeld JW, et al. COVID-19 Convalescent plasma for the treatment of immunocompromised patients: A systematic review and meta-analysis. Journal of the American Medical Association: Network Open. 2023; doi:10.1001/jamanetworkopen.2022.50647.
  9. COVID-19 treatments and medications. Centers for Disease Control and Prevention. Accessed May 2, 2023.
  10. Kim AR. Coronavirus disease 2019 (COVID-19): Management in hospitalized adults. Accessed May 2, 2023.
  11. Infectious disease, HLA and ABO donor qualification testing. American Red Cross. Accessed May 3, 2023.
  12. Tulledge-Scheitel, S (expert opinion). Mayo Clinic. May 5, 2023.

Convalescent plasma therapy