Mayo Clinic's approach

Mayo Clinic's highly skilled neurosurgeons are trained in brain biopsy and other surgical procedures of the brain. Mayo Clinic doctors and surgeons trained in conditions of the nervous system (neurologists and neurosurgeons) have experience diagnosing and treating conditions that may be diagnosed as a result of a brain biopsy. These conditions include brain tumors, infections, brain cancer and others.

A key part of this approach is matching each brain biopsy to Mayo Clinic specialists with focused expertise in the specific area of the brain involved. This subspecialized experience helps improve diagnostic accuracy while supporting safety during the procedure.

Collaboration

Mayo Clinic healthcare professionals in neurology and neurosurgery work with a multidisciplinary team of experts in many specialties. The collaborative approach provides comprehensive care for adults and children who need a brain biopsy to diagnose the cause of their symptoms.

They work with experts in brain and nervous system imaging (radiologists) and with specialists in radiation oncology, pain medicine, and physical medicine and rehabilitation.

Specialists in Mayo Clinic's Brain Tumor Program offer personalized and comprehensive care to people with brain tumors.

Expertise

Mayo Clinic healthcare professionals in neurology, neurosurgery and pediatric neurosurgery are on the leading edge of treating brain conditions. Mayo Clinic's innovative approaches include awake brain surgery, robotics, intraoperative MRI, computer-assisted brain surgery and deep brain stimulation.

Technology

Mayo Clinic is a leader in neurosurgery. Doctors, surgeons and other healthcare professionals use state-of-the-art facilities that include an intraoperative MRI suite, comprehensive intraoperative neuromonitoring and image-guided surgery.

Expertise and rankings

Learn more about Mayo Clinic's neurology and neurosurgery departments' expertise and rankings.

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, are ranked among the Best Hospitals for neurology and neurosurgery in the U.S. News & World Report Best Hospitals rankings.

Mayo Clinic has been recognized as a top cancer hospital by U.S. News & World Report since it began publishing rankings in 1990. Most recently, Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona, have been recognized among the top Cancer hospitals in the nation by U.S. News & World Report.

Mayo Clinic Comprehensive Cancer Center meets the strict standards for a U.S. National Cancer Institute comprehensive cancer center. These standards recognize scientific excellence and a multispecialty approach focused on cancer prevention, diagnosis and treatment.

More information about billing and insurance:

Mayo Clinic in Arizona, Florida and Minnesota

Mayo Clinic Health System

March 10, 2026
  1. Mathon B. Brain biopsies. Neuromethods. 2025; doi:10.1007/978-1-0716-4514-7.
  2. Riche M, et al. Complications after frame-based stereotactic brain biopsy: A systematic review. Neurosurgical Review. 2021; doi:10.1007/s10143-019-01234-w.
  3. He L, et al. Stereotactic biopsy for brainstem lesions: A meta-analysis with noncomparative binary data. Cancer Control. 2021; doi:10.1177/10732748211059858.
  4. Central nervous system tumors treatment (PDQ) — Health professional version. National Cancer Institute. https://www.cancer.gov/types/brain/hp/adult-brain-treatment-pdq. Accessed Jan. 15, 2026.
  5. Stereotactic brain biopsy. American Association of Neurological Surgeons. https://www.aans.org/patients/conditions-treatments/stereotactic-brain-biopsy. Accessed Jan. 15, 2026.
  6. Tests for brain tumors in adults. American Cancer Society. https://www.cancer.org/cancer/types/brain-spinal-cord-tumors-adults/detection-diagnosis-staging/how-diagnosed.html. Accessed Jan. 15, 2026.
  7. Mathon B, et al. Outpatient stereotactic brain biopsies. Neurosurgical Review. 2022; doi:10.1007/s10143-021-01593-3.
  8. Medical review (expert opinion). Mayo Clinic. Jan. 29, 2026.