Departments and specialties

Mayo Clinic has one of the largest and most experienced practices in the United States, with campuses in Arizona, Florida and Minnesota. Staff skilled in dozens of specialties work together to ensure quality care and successful recovery.


Mayo Clinic doctors and surgeons trained in heart rhythm disorders conduct research to improve care for people living with arrhythmias.

Areas of investigation include:

  • Leading a multicenter, multinational trial to compare drug therapy with cardiac ablation for people with arrhythmia
  • Designing and testing innovative catheters to deliver ablation, including improved cryoablation balloons
  • Studying the genetics of heart arrhythmias
  • Improving technology and techniques used to diagnose arrhythmias

This emphasis on research and innovation increases the treatment choices available to Mayo Clinic patients. You may also have the opportunity to participate in clinical trials. Learn more about heart rhythm disease research and cardiovascular research at Mayo Clinic.


See a list of publications by Mayo Clinic authors on cardiac ablation for atrial fibrillation on PubMed, a service of the National Library of Medicine.

Research Profiles

Atrial fibrillation ablation care at Mayo Clinic

Jan. 03, 2018
  1. Barbara Woodward Lips Patient Education Center. Ablation of the pulmonary vein for atrial fibrillation. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
  2. Catheter ablation. National Heart, Lung and Blood Institute. Accessed Oct. 13, 2016.
  3. Prystowsky EN, et al. Treatment of atrial fibrillation. Journal of the American Medical Association. 2015;314:278.
  4. Passman R. Catheter ablation to prevent recurrent atrial fibrillation: Clinical applications. Accessed Aug. 4, 2016.
  5. Bonow RO, et al. Atrial fibrillation: Clinical features, mechanisms, and management. In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 10th ed. Philadelphia, Pa.: Saunders Elsevier; 2015. Accessed Oct. 12, 2015.
  6. January CT, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: Executive summary. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology. 2014;64:2246.
  7. Huang SKS, et al., eds. Pulmonary vein isolation for atrial fibrillation. In: Catheter Ablation of Cardiac Arrhythmias, 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2015. Accessed Oct. 12, 2016.
  8. Calkins H, et al. 2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. A Report of the Heart Rhythm Society Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Heart Rhythm. 2012;9:632.
  9. Schaff HV, et al. Cox-Maze procedure for atrial fibrillation: Mayo Clinic experience. Seminars in Thoracic and Cardiovascular Surgery. 2000;12:30.
  10. Patel NJ, et al. Contemporary utilization and safety outcomes of catheter ablation of atrial flutter in the United States: Analysis of 89,638 procedures. Heart Rhythm. 2016;13:1317.
  11. Murphy JG, et al., eds. Atrial fibrillation and flutter. In: Mayo Clinic Cardiology: Concise Textbook. 4th ed. New York, N.Y.: Oxford University Press; 2013.
  12. Chatterjee NA, et al. Atrioventricular nodal ablation in atrial fibrillation: A meta-analysis and systematic review. Circulation: Arrhythmia and Electrophysiology. 2012;5:68.
  13. Al-Hijji MA, et al. Trends and predictors of repeat catheter ablation for atrial fibrillation. American Heart Journal. 2016;171:48.
  14. Riggin EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. July 27, 2016.
  15. Al-Khatib SM, et al. Planning the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a collaborative pan-stakeholder critical path registry model: A cardiac safety research consortium "incubator" think tank. American Heart Journal. 2010;149:17.
  16. Wokhlu A, et al. Long-term outcomes of atrial fibrillation ablation: Impact and predictors of very late recurrence. Journal of Cardiovascular Electrophysiology. 2010;21:1071.
  17. Noseworthy PA, et al. Risk of stroke after catheter ablation versus cardioversion for atrial fibrillation: A propensity-matched study of 24,244 patients. Heart Rhythm. 2015;12:1154.
  18. Packer DL, et al. Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: First results of the North American Arctic Front (STOP AF) Pivotal Trial. Journal of the American College of Cardiology. 2013;61:1713.
  19. Fender EA, et al. Pulmonary vein stenosis after atrial fibrillation ablation. EuroIntervention. 2016;12(suppl X):x31.
  20. Mulpuru SK (expert opinion). Mayo Clinic, Phoenix/Scottsdale, Ariz. Oct. 10, 2016.

Atrial fibrillation ablation