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Distribution across the blood brain barrier was evaluated after a single 30 mg/kg oral LIS dose, and concentrations of the active metabolite BAL27862 were measured by liquid chromatography-tandem mass spectrometry.
We are currently using this model to screen a library of ~58,000 small-molecules with increased probability of oral bioavailability and blood brain barrier penetration to identify compounds that diminish both TDP-43 aggregation and t...
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