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  1. Effect of Tirzepatide on Physical Function in Postmenopausal Women With Obesity - Mayo Clinic

    About this study. In postmenopausal women, obesity increases the risk of physical function decline and premature aging, thus increasing the risk of vascular ...

  2. Doxorubicin and Cyclophosphamide Followed By Trastuzumab, Paclitaxel, and Lapatinib in Treating Patients With Early-Stage HER2-Positive Breast Cancer That Has Been Removed By Surgery - Mayo Clinic

    RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, work in different ways to stop the growth of tumor cells, either ...

  3. Study of Selective BRAF Kinase Inhibitor Dabrafenib Monotherapy Twice Daily and in Combination with Dabrafenib Twice Daily and Trametinib Once Daily in Combination Therapy in Subjects With BRAF V600E Mutation Positive Metastatic (Stage IV) Non-small Cell Lung Cancer - Mayo Clinic

    Subjects will receive dabrafenib 150 mg twice daily (BID) in monotherapy treatment and dabrafenib 150 mg bid and trametinib 2 mg once daily in combination ...

  4. A Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Isatuximab in Patients With Multiple Myeloma - Mayo Clinic

    About this study. Primary Objective: - Part A: To evaluate the safety of SAR650984 (isatuximab) in patients with relapsed/refractory multiple myeloma (RRMM) ...

  5. A Study of the Use of the Hansen Medical System in Patients with Paroxysmal Atrial Fibrillation - Mayo Clinic

    The purpose of this study is to assess the safety and performance of the Hansen Medical Sensei Robotic System and Artisan Catheter when used to robotically ...

  6. A Study of Colesevelam in Fecal Incontinence - Mayo Clinic

    The purpose of this study is to compare the effects of a combination of colesevelam and clonidine to a placebo on bowel symptoms in patients with urge or ...

  7. Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation - Mayo Clinic

    The purpose of this study is to understand the differential response of lipolysis in obesity to interventions that should stimulate lipolysis and intracellular ...

  8. Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer - Mayo Clinic

    Sorafenib tosylate and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. The addition of everolimus to ...

  9. A Study of Ranolazine in ALS - Mayo Clinic

    The purpose of this study is to evaluate safety, effect on cramps, function and quality of life of ranolazine versus placebo for the treatment of ALS.

  10. Study Of Quemliclustat And Chemotherapy Versus Placebo And Chemotherapy In Patients With Metastatic Pancreatic Ductal Adenocarcinoma - Mayo Clinic

    About this study. The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel ...