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  1. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Mayo Clinic

    About this study. Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of ...

  2. Testicular Tissue Cryopreservation in Children - Mayo Clinic

    This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical ...

  3. A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor - Mayo Clinic

    About this study. This is a Phase II, open-label, two strata, multicenter, prospective study of plerixafor-mobilized HLA-identical sibling allografts in ...

  4. A Study to Evaluate Dapagliflozin to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure - Mayo Clinic

    The purpose of this international study is to evaluate the effect of dapagliflozin 10 mg versus placebo in HFpEF patients, given once daily in addition to ...

  5. A Study of LNK01002 in Patients With Primary (PMF) or Secondary Myelofibrosis (PV-MF, ET-MF) or Acute Myeloid Leukemia - Mayo Clinic

    The purpose of this study is to evaluate safety and tolerability of multi-kinase inhibitor LNK01002 in patients with primary myelofibrosis (MF), or MF due to ...

  6. A Study to Evaluate the Safety and Effectiveness of Metformin and Nelfinavir with Bortezomib in Patients with Relapsed and/or Refractory Multiple Myeloma - Mayo Clinic

    The purpose of this study is to assess the maximum tolerated dose (MTD) of administering metformin in combination with nelfinavir in patients with relapsed/ ...

  7. A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension - Mayo Clinic

    The purpose of this study is to evaluate the effect of sotatercept (ACE-011) in adults with Pulmonary Arterial Hypertension. Each eligible participant will ...

  8. A Study to Evaluate Gemcitabine and MK-3475 (Pembrolizumab) to Treat Patients with BCG-Unresponsive Non-Muscle Invasive Bladder Cancer - Mayo Clinic

    The purpose of this study is to assess the effect of adding pembrolizumab to gemcitabine in treating patients with non-muscle invasive bladder cancer whose ...

  9. A Study to Evaluate Firstline Pembrolizumab Alone or in Combination with Pemetrexed and Carboplatin in Induction/Maintenance or Postprogression in Treating Patients with Stage IV Non-squamous Non-small Cell Lung Cancer - Mayo Clinic

    Drugs used in chemotherapy, such as pemetrexed and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by ...

  10. A Study to Understand Serum Biotin Clearance as a Means to Mitigate the Risk of Biotin Interference with Clinical Laboratory Tests - Mayo Clinic

    The purpose of this study is to determine the clearance rate of biotin from the serum in patients with impaired renal function following ingestion of over-the- ...