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  1. A Study to Evaluate the Effect of Olorinab on Gastrointestinal Transit in Patients with Irritable Bowel Syndrome - Mayo Clinic

    The purpose of this study is to evaluate gastric, small-bowel, and colonic transit in subjects with IBS-C and IBS-D treated with multiple (three times daily) ...

  2. A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia - Mayo Clinic

    The purpose of this study is to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Participants with Glanzmann ...

  3. A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease - Mayo Clinic

    The primary objective is to evaluate whether macitentan 10 mg reduces N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as compared to placebo in these ...

  4. ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders - Mayo Clinic

    The purpose of this study is to characterize the safety, effectiveness and practice of treatments for all people with congenital and acquired hematologic ...

  5. An Efficacy and Safety Trial of MK-8931 in Mild to Moderate Alzheimer's Disease (P07738) - Mayo Clinic

    The purpose of Part I of the study is to assess the efficacy and safety of MK-8931 compared with placebo administered for 78 weeks in the treatment of ...

  6. Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

    This is a multicenter, international, double-blind study of the administration of mavacamten in participants with symptomatic obstructive HCM (oHCM).

  7. Study to Evaluate the Safety and Effectiveness of BMS-986036 in Adults with Nonalcoholic Steatophepatitis (NASH) and Stage 3 Liver Fibrosis - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  8. A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional Therapies But Have Not Failed Biologic Therapy - Mayo Clinic

    The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in participants with moderately and ...

  9. Study of TERN-601 in Adults with Overweight or Obesity - Mayo Clinic

    Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and ...

  10. An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered via Transendocardial Catheter-based Injections to Subjects with Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM) - Mayo Clinic

    An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered via Transendocardial Catheter-based Injections to Subjects with Heart Failure Due to ...