Search Results 31-40 of 16231 for senescent cells senolytic
With further research, senolytic therapy may be considered for a future role in treatment of heart failure, the study concludes. "Senescence and aging are well- ...
van Deursen developed a facility to create mouse models of human disease. He unexpectedly hit upon a major breakthrough — one that researchers had been trying ...
“Additionally, we have developed a new senescent cell transplantation model that allows us to test whether clearing senescent cells alleviates or delays ...
Researchers in the Regenerative Neurosurgery and Neuro-Oncology Lab are studying how identify and potentially kill residual senescent tumor cells after ...
The results, which appear today in Nature, demonstrate that clearance of senescent cells delays tumor formation, preserves tissue and organ function, and ...
Zhu's research is to unravel the mechanisms of senescent cell involvement in these diseases and develop senolytic drugs to precisely target senescent cells.
... senescent cells in the processes of aging and cancer. Cellular senescence, a state of irreversible cell cycle arrest that limits the ability of cells to ...
... cells and senolytic drugs ... Cellular senescence leads cells to acquire a senescence ... Senolytic compounds target pro-survival pathways in senescent cells, and ...
Now researchers are looking at the toxic proteins released by senescent cells, called the senescence-associated secretory phenotype, or SASP. They are ...
LeBrasseur and colleagues demonstrated that the SASP contributes to tissue dysfunction by inducing paracrine senescence and inflammation, stem cell dysfunction, ...
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